A randomised Phase IIa trial of amine oxidase copper-containing 3 (AOC3) inhibitor BI 1467335 in adults with non-alcoholic steatohepatitis [PDF]
Nature Communications, 2023 Non-alcoholic steatohepatitis (NASH) is a progressive, inflammatory liver disease with no approved pharmacological treatment. This Phase IIa, double-blind, placebo-controlled, multicentre trial (ClinicalTrials.gov: NCT03166735) investigated ...
Philip N Newsome +2 more
exaly +12 more sources
Increased atherosclerotic plaque in AOC3 knock-out in ApoE−/− mice and characterization of AOC3 in atherosclerotic human coronary arteries [PDF]
Frontiers in Cardiovascular Medicine, 2022 IntroductionAmine oxidase copper containing 3 (AOC3) displays adhesion between leukocytes and endothelial cells and enzymatic functions. Given its controversial role in atherogenesis, we proposed to investigate the involvement of AOC3 in the formation of
Sirpa Jalkanen, Nathalie Mercier
exaly +11 more sources
Pan-cancer analysis reveals AOC3 as a potential therapeutic biomarker for colorectal cancer [PDF]
Discover OncologyAmine oxidase copper containing 3 (AOC3) had been reported to play an important regulatory role in the biological functional pathways, immune microenvironment and cellular function.
Guanlong Wang +5 more
exaly +5 more sources
AOC3 accelerates lung metastasis of osteosarcoma by recruiting tumor-associated neutrophils, neutrophil extracellular trap formation and tumor vascularization [PDF]
HeliyonOsteosarcoma (OS) has strong invasiveness, early metastasis, high drug resistance, and poor prognosis. At present, OS still lacks reliable biomarkers, which makes early diagnosis of OS more difficult.
Luxia Qi +7 more
exaly +6 more sources
NG2/CSPG4, CD146/MCAM and VAP1/AOC3 are regulated by myocardin-related transcription factors in smooth muscle cells [PDF]
Scientific Reports, 2021 The present work addressed the hypothesis that NG2/CSPG4, CD146/MCAM, and VAP1/AOC3 are target genes of myocardin-related transcription factors (MRTFs: myocardin/MYOCD, MRTF-A/MKL1, MRTF-B/MKL2) and serum response factor (SRF).
Catarina Rippe +2 more
exaly +4 more sources
Amine oxidase copper-containing 3 (AOC3) inhibition: a potential novel target for the management of diabetic retinopathy [PDF]
International Journal of Retina and Vitreous, 2021 Background Diabetic retinopathy (DR), a microvascular complication of diabetes, is the leading cause of visual impairment in people aged 20–65 years and can go undetected until vision is irreversibly lost.
Ngaihang Victor Chong, Quan Dong Nguyen
exaly +4 more sources
Implication for Functions of the Ectopic Adipocyte Copper Amine Oxidase (AOC3) from Purified Enzyme and Cell-Based Kinetic Studies [PDF]
PLoS ONE, 2012 AOC3 is highly expressed in adipocytes and smooth muscle cells, but its function in these cells is currently unknown. The in vivo substrate(s) of AOC3 is/are also unknown, but could provide an invaluable clue to the enzyme's function.
Judith P Klinman
exaly +7 more sources
Elucidating the roles of SOD3 correlated genes and reactive oxygen species in rare human diseases using a bioinformatic-ontology approach. [PDF]
PLoS ONESuperoxide Dismutase 3 (SOD3) scavenges extracellular superoxide giving a hydrogen peroxide metabolite. Both Reactive Oxygen Species diffuse through aquaporins causing oxidative stress and biomolecular damage.
Mark Stanworth, Shu-Dong Zhang
doaj +5 more sources
Expression of Amine Oxidase Proteins in Adrenal Cortical Neoplasm and Pheochromocytoma [PDF]
Biomedicines, 2023 We delved into the expression of amine oxidase family proteins and their potential significance in adrenal gland neoplasm. Tissue microarrays were prepared for 132 cases of adrenal cortical neoplasm (ACN) consisting of 115 cases of adrenal cortical ...
Eun Kyung Kim, Ja Seung Koo
doaj +2 more sources
Screening and identification of novel protein markers of early-stage lung cancer and construction and application of screening models [PDF]
Frontiers in OncologyObjectiveMolecular biomarkers have the potential to improve the current state of early screening of lung cancer. This investigation aimed to identify novel protein markers for early-stage lung cancer and combine them with traditional tumor markers to ...
Huijie Yuan +7 more
doaj +2 more sources