Crosstalk of cell death pathways unveils an autophagy-related gene AOC3 as a critical prognostic marker in colorectal cancer [PDF]
Communications BiologyThe intricate crosstalk of various cell death forms was recently implicated in cancers, laying a foundation for exploring the association between cell death and cancers.
Hui Xu +7 more
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Identification of AOC3 and LRRC17 as Colonic Fibroblast Activation Markers and Their Potential Roles in Colorectal Cancer Progression [PDF]
Asian Pacific Journal of Cancer Prevention, 2023 Accumulation of cancer-associated fibroblasts (CAFs) in the tumor stroma is linked to poor prognosis in colorectal cancer (CRC). CAF-cancer cell interplay, facilitated by secretomes including transforming growth factor-beta 1 (TGF-β1), supports fibroblast activation, drives colorectal carcinogenesis, and contributes to CRC aggressive phenotypes ...
Sahira Syamimi Ahmad Zawawi +2 more
exaly +4 more sources
Proteomic analysis of premature umbilical cord blood and its relationship with bronchopulmonary dysplasia [PDF]
Italian Journal of PediatricsBackground Bronchopulmonary dysplasia (BPD) frequently occurs in preterm infants, causing significantly impaired lung function and increased mortality rates.
Jia Chen +6 more
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Identification and validation of hub genes in drug induced acute kidney injury basing on integrated transcriptomic analysis [PDF]
Frontiers in Immunology, 2023 BackgroundDrug-induced acute kidney damage (DI-AKI) is a clinical phenomenon of rapid loss of kidney function over a brief period of time as a consequence of the using of medicines.
Yi-Xuan Deng +11 more
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Transcriptomic and metabolomic analysis clarify the molecular mechanisms underlying the formation of sexual and apomictic Persian walnut (Juglans regia L.) embryos [PDF]
Frontiers in Plant SciencePurposePersian walnut (Juglans regia L.) is one of the world’s economically significant dry fruits, which stems from the high nutritional value of its kernel and its uses in diverse industries. Walnuts species can employ sexual and apomictic reproductive
Chunjie Bao +7 more
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Exploratory research on therapeutic agents combined with early diagnostic biomarkers for colorectal cancer [PDF]
Frontiers in PharmacologyIntroductionColorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. Although diagnostic and therapeutic strategies have advanced, the molecular mechanisms driving CRC pathogenesis are not fully understood, highlighting the ...
Qiming Liao +7 more
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Integrative Bioinformatics and Experimental Validation Establish CCNB1 as a Potential Biomarker for Diagnosis and Prognosis in Colorectal Cancer [PDF]
Current Issues in Molecular BiologyColorectal cancer (CRC) is a prevalent and lethal malignancy worldwide. Despite extensive research, core genes for diagnosis and prognosis in CRC remain to be fully elucidated.
Yao Zou, Quan Zou, Zhen Li
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The tree of life of copper-containing amine oxidases [PDF]
Frontiers in Plant ScienceCopper-containing amine oxidases (CuAOs) catalyze the terminal oxidation of polyamines (PAs), producing ammonium, an aminoaldehyde, and hydrogen peroxide (H2O2). Plant CuAOs are induced by stress-related hormones such as methyl-jasmonate (MeJA), abscisic
Zaibao Zhang +5 more
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Comprehensive analysis of the metabolomics and transcriptomics uncovers the dysregulated network and potential biomarkers of Triple Negative Breast Cancer [PDF]
Journal of Translational MedicineTriple-negative breast cancer (TNBC) is known for its aggressive nature, lack of effective diagnostic tools and treatments, and generally poor prognosis.
Sisi Gong +6 more
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Integrative Spatial Proteomics and Single-Cell RNA Sequencing Unveil Molecular Complexity in Rheumatoid Arthritis for Novel Therapeutic Targeting [PDF]
ProteomesUnderstanding the heterogeneity of Rheumatoid Arthritis (RA) and identifying therapeutic targets remain challenging using traditional bulk transcriptomics alone, as it lacks the spatial and protein-level resolution needed to fully capture disease and ...
Xue Wang +13 more
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