Results 61 to 70 of about 191,054 (269)

Optical coherence tomography and multiphoton microscopy offer new options for the quantification of fibrotic aortic valve disease in ApoE−/− mice

Scientific Reports, 2021
Aortic valve sclerosis is characterized as the thickening of the aortic valve without obstruction of the left ventricular outflow. It has a prevalence of 30% in people over 65 years old.
Anett Jannasch, Christian Schnabel, Roberta Galli, Saskia Faak, Petra Büttner, Claudia Dittfeld, Sems Malte Tugtekin, Edmund Koch, Klaus Matschke   +8 more
doaj   +1 more source

De Novo Heterozygous ZFX Frameshift Variant in a Female With an X‐Linked Neurodevelopmental Disorder

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Germline ZFX variants are associated with an X‐linked neurodevelopmental disorder, with 14 males and 16 females reported to date. We describe a 20‐year‐old female with a heterozygous ZFX frameshift variant, p.(Met666Valfs*2), identified by genome sequencing, previously reported in an affected male.
Iftekhar A. Showpnil, Allison Daley, Emily R. Sites, Shayne M. Plourde, Jesse M. Hunter, Dennis W. Bartholomew, April N. Lehman, Daniel C. Koboldt, Rolf W. Stottmann   +8 more
wiley   +1 more source

Hemangioma of the Atherosclerotic Changed Aortic Valve

Case Reports in Cardiology, 2019
The incidence of heart valve hemangioma is very low and is mostly observed in the mitral and tricuspid valve. In 2006, two cases of aortic valve hemangioma were reported for the first time, including one with calcifying aortic valve stenosis.
A. van Broekhoven, P. A. J. Krijnen, H. W. M. Niessen, A. B. A. Vonk   +3 more
doaj   +1 more source

Age, Sex, and Valve Phenotype Differences in Fibro‐Calcific Remodeling of Calcified Aortic Valve

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background In calcific aortic valve disease on tricuspid aortic valves (TAVs), men have higher aortic valve calcification and less fibrosis than women. However, little is known in bicuspid aortic valves (BAV).
Martine Voisine, Maxime Hervault, Mylène Shen, Anne‐Julie Boilard, Benoît Filion, Mickael Rosa, Yohan Bossé, Patrick Mathieu, Nancy Côté, Marie‐Annick Clavel   +9 more
doaj   +1 more source

Non‐RASopathy Genetic Syndromes Identified as the Molecular Cause of Disease in Patients Previously Diagnosed With Noonan Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Noonan Syndrome (NS) is a clinically and genetically heterogeneous condition characterized by typical facial dysmorphisms, short stature, congenital heart defects, and developmental delays. While variants in genes such as PTPN11, SOS1, and RAF1 account for most genetically confirmed cases, diagnosis is challenging due to phenotypic overlap ...
Gabriela Jeesoo Kim, Alexsandra Christianne Malaquias, Debora Romeo Bertola, Raissa Carneiro Rezende, Laurana De Polli Cellin, Lucas Vieira Lacerda Pires, Ana Maria Santillan‐Vasconez, Antônio Marcondes Lerario, Renata da Cunha Scalco, Alexander Augusto de Lima Jorge   +9 more
wiley   +1 more source

Pimobendan alleviates myocyte apoptosis and fibrosis associated with mitral regurgitation by targeting endoplasmic reticulum stress

Animal Models and Experimental Medicine, EarlyView.
Mitral regurgitation (MR) causes volume overload and disrupts Ca2+ homeostasis. The volume overload leads to cardiac hypertrophy and fibrosis inferred from histopathological studies. Cardiac hypertrophy was identified by increased myocyte cross‐sectional area, left atrial‐to‐aortic root ratio, and left ventricular internal diameter at end‐diastole ...
Pakit Boonpala, Sushawadee Tongta, Nakkawee Saengklub, Vudhiporn Limprasutr, Sirinapa Srikam, Wilawan Ji‐au, Tussapon Boonyarattanasoonthorn, Yaowalak Panyasing, Sarawut Kumphune, Sarinee Kalandakanond‐Thongsong, Anusak Kijtawornrat   +10 more
wiley   +1 more source

Commando procedure in a radiated chestCentral Message

JTCVS Techniques, 2022
Jennifer L. Perri, MD, MBA, Douglas R. Johnston, MD   +1 more
doaj   +1 more source

The use of transgenic animals for xenotransplantation: An update

Animal Models and Experimental Medicine, EarlyView.
One way to produce genetically modified pigs is to use somatic cell nuclear transfer (SCNT). This procedure involves removing the metaphase plate from a mature oocyte using micromanipulation and then transferring the modified nucleus from the donor somatic cell to the oocyte.
Julia Motławska, Ana Amaral, Marta Cerveira‐Pinto, Paweł Kordowitzki   +3 more
wiley   +1 more source

Aortic Valve Sclerosis and Degenerative Valve Disease in a Nigerian Population: An Echocardiographic Study

Global Heart
Background: The burden of degenerative valve disease is increasing globally because of population aging. However, data on this condition is scarce in Nigeria and across Africa.
Olugbenga O. Abiodun, Ibrahim L. Salau, Tina Anya   +2 more
doaj   +1 more source

Noradrenergic and cholinergic innervation of the normal human heart and changes associated with cardiomyopathy

The Anatomical Record, EarlyView.
Abstract Autonomic nerves are crucial in cardiac function and pathology. However, data on the distribution of cholinergic and noradrenergic nerves in normal and pathologic human hearts is lacking. Nonfailing donor hearts were pressure‐perfusion fixed, imaged, and dissected. Left ventricular cardiomyopathy samples were also obtained.
Peter Hanna, Donald B. Hoover, Logan G. Kirkland, Elizabeth H. Smith, Megan D. Poston, Stanley G. Peirce, Chloe G. Garbe, Tasha K. Phillips, Steven Cha, Shumpei Mori, Jaclyn A. Brennan, John Andrew Armour, Eric Rytkin, Igor R. Efimov, Olujimi A. Ajijola, Jeffrey L. Ardell, Kalyanam Shivkumar   +16 more
wiley   +1 more source