Results 41 to 50 of about 69,987 (253)

Combining actigraphy, ecological momentary assessment and neuroimaging to study apathy in patients with schizophrenia [PDF]

, 2018
Background: Apathy can be defined as a reduction of goal-directed behavior and is a strong predictor for poor functional outcome in schizophrenia. However, no objective measure of apathy has been identified and assessment is limited to retrospective ...
Seifritz, Erich, Erich Seifritz, Habermeyer, Benedikt, Walther, Sebastian, Kluge, Agne, Kaiser, Stefan, Martin Bischof, Stefan Kaiser, Benedikt Habermeyer, Kirschner, Matthias; https://orcid.org/, Kirschner, Matthias, Hager, Oliver M, Oliver M. Hager, Matthias Kirschner, Sebastian Walther, Agne Kluge, Bischof, Martin   +16 more
core   +1 more source

Bi‐ and Mono‐Allelic RFC1 Expansion in a North American Cohort With Idiopathic Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective RFC1 biallelic repeat expansion is increasingly recognized as a cause of chronic idiopathic axonal polyneuropathy (CIAP), but it remains challenging to know who to test. This study aims to determine the prevalence of biallelic and monoallelic RFC1 expansions and their corresponding neuropathy phenotypes in CIAP patients and identify ...
Amro M. Stino, Lavanya Muthukumar, Evan L. Reynolds, Peter Todd, Sinem Ovunc, Sheng Chih Jin, Zitian Tang, Simone Thomas, PNRR Study Group, Ahmet Höke, Brian C. Callaghan, Sarah Berth, Vinay Chaudhry, David Cornblath, Leana Doherty, Lindsey Hayes, Hristelina Ilieva, Thomas Lloyd, Mohammad Khoshnoodi, Brett McCray, Brett Morrison, Bipasha Mukherjee‐Clavin, Lyle Ostrow, Michael Polydefkis, Ricardo Roda, Charlotte Sumner   +25 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Correlates and predictors of apathy, depression and fatigue post-stroke [PDF]

, 2014
Stroke is a leading cause of disability in the UK and has a range of psychological sequelae including apathy, depression and fatigue. Psychological consequences of stroke have been associated with poor rehabilitation outcomes.
Carroll, C.
core  

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source

Non-pharmacologic interventions to treat apathy in Parkinson’s disease: A realist review

Clinical Parkinsonism & Related Disorders, 2021
Introduction: There is a diverse body of evidence investigating non-pharmacological treatment options for apathy in Parkinson’s disease (PD). We aimed to better understand the context and mechanisms by which non-pharmacological interventions may improve ...
Bria Mele, Zahinoor Ismail, Zahra Goodarzi, Tamara Pringsheim, Grace Lew, Jayna Holroyd–Leduc   +5 more
doaj   +1 more source

Editor’s Pick: Clinical Significance of Apathy in Parkinson’s Disease [PDF]

, 2016
Apathy, or lack of motivation, is increasingly recognised as a major factor affecting quality of life and prognosis in Parkinson’s disease (PD). Impacting every stage of the disease, including de novo cases, reports have suggested it can affect up to 70%
Kinan Muhammed, Masud Husain
core  

Limbic Serotonergic Plasticity Contributes to the Compensation of Apathy in Early Parkinson's Disease [PDF]

, 2022
BACKGROUND De novo Parkinson's disease (PD) patients with apathy exhibit prominent limbic serotonergic dysfunction and microstructural disarray.
Tremblay, Léon, Castrioto, Anna, Krack, Paul, Eugénie Lhommée, Metereau, Elise, Lancelot, Sophie, Maillet, Audrey, Meoni, Sara, Léon Tremblay, Hélène Klinger, Stéphane Prange, Sophie Lancelot, Sara Meoni, Emmanuel Broussolle, Lhommée, Eugénie, Elise Metereau, Schmitt, Emmanuelle, Broussolle, Emmanuel, Anna Castrioto, Emmanuelle Schmitt, Amélie Bichon, Stéphane Thobois, Bichon, Amélie, Prange, Stéphane, Klinger, Hélène, Thobois, Stéphane, Paul Krack, Audrey Maillet   +27 more
core   +1 more source

Bioengineered Interfaces for Peripheral Nerve Sensory Restoration

Advanced Materials, EarlyView.
Half of amputees abandon their prosthetics for lack of feeling. This review charts the full path from peripheral nerve injury to restored sensation, through surgical, regenerative, noninvasive, and implanted approaches, and shows how injury type and interface material properties determine which strategy can deliver naturalistic feedback, and why ...
Sydney Swedick, Salim El Hadwe, Kesi Liang, George G. Malliaras, Damiano G. Barone   +4 more
wiley   +1 more source

Apathy and white matter integrity in Alzheimer's disease: a whole brain analysis with tract-based spatial statistics. [PDF]

PLoS ONE, 2013
The aim of this study was to investigate the microstructural alterations of white matter (WM) in Alzheimer's disease (AD) patients with apathy and to observe the relationships with the severity of apathy. Sixty drug-naïve subjects took part in this study
Changtae Hahn, Hyun-Kook Lim, Wang Yeon Won, Kook Jin Ahn, Won-Sang Jung, Chang Uk Lee   +5 more
doaj   +1 more source