Results 11 to 20 of about 7,987 (192)
Apatinib for the treatment of gastric cancer [PDF]
Expert Opinion on Pharmacotherapy, 2014 Antiangiogenesis therapy plays an important role in cancer treatment. Apatinib mesylate, a small molecule tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor-2, has been recommended as third-line treatment for metastatic gastric cancer patients.The current review summarizes the publications and conference reports relating to
Ruixuan, Geng, Jin, Li
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Apatinib inhibits tumor growth and angiogenesis in PNET models [PDF]
Endocrine Connections, 2019 Angiogenesis has a pivotal role in the growth and metastasis of pancreatic neuroendocrine tumors (PNETs). Apatinib inhibits angiogenesis as a highly selective KDR inhibitor and has been used to treat advanced gastric cancer and malignancies in clinical ...
Shan Wu +5 more
doaj +2 more sources
Apatinib has anti-tumor effects and induces autophagy in colon cancer cells [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Apatinib recently has been used to treat patients with gastric cancer, but the function of apatinib in colon cancer remains unclear.
Wu Lu +5 more
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Apatinib targets both tumor and endothelial cells in hepatocellular carcinoma
Cancer Medicine, 2018 Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed malignancies worldwide with poor prognosis and tends to be hypervascular. Aberrant expression of the vascular endothelial growth factor 2 (VEGFR‐2) has been implicated in the ...
Chaoxu Yang, Shukui Qin
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Effect of apatinib on the pharmacokinetics of tramadol and O-desmethyltramadol in rats [PDF]
PeerJ, 2023 Since the combination of anticancer drugs and opioids is very common, apatinib and tramadol are likely to be used in combination clinically. This study evaluated the effects of apatinib on the pharmacokinetics of tramadol and its main metabolite O ...
Su-su Bao +7 more
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In vitro and in vivo apatinib inhibits vasculogenic mimicry in melanoma MUM-2B cells.
PLoS ONE, 2018 The effect of apatinib on the formation of vasculogenic mimicry (VM) was studied in a malignant melanoma cell line. MUM-2B cells cultured in three-dimensional Matrigel were treated with varying concentrations (0, 0.01, 0.05, 0.1, 0.5 μmol/L) of apatinib ...
Zong-Jun-Lin Liu +7 more
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BMC CancerBackground Data on long-term cancer survivors treated with apatinib are lacking. This study aimed to describe the characteristics of long-term cancer survivors after apatinib-based therapy, and to know about their satisfaction degree with apatinib and ...
Tingting Zhang +27 more
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BMC MedicineBackground This study aimed to assess the efficacy and safety of transarterial chemoembolization (TACE) in combination with apatinib (TACE-apatinib) for patients with unresectable hepatocellular carcinoma (HCC).
Xue-Feng Kan +21 more
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Genome-wide CRISPR screen identifies ESPL1 limits the response of gastric cancer cells to apatinib
Cancer Cell InternationalApatinib was the first anti-angiogenic agent approved for treatment of metastatic gastric cancer (GC). However, the emergence of resistance was inevitable. Thus investigating new and valuable off-target effect of apatinib directly against cancer cells is
Bei Zhang +6 more
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Translational OncologyApatinib, a small-molecule inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), shows efficient antitumor activity in heavily pretreated metastatic triple-negative breast cancer (TNBC).
Jing Wu +5 more
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