Results 41 to 50 of about 7,987 (192)

Apatinib suppresses lung cancer stem-like cells by complex interplay between β-catenin signaling and mitochondrial ROS accumulation

Cell Death Discovery, 2021
The abnormal activation of Wnt/β-catenin signaling plays a critical role in the development of lung cancer, which is also important in the generation and maintenance of lung cancer stem cell (CSC).
Jianyun Zhu, Xiaoting Li, Chunhua Liang, Xu Zhou, Miaomiao Ge, Yue Chen, Jianliang Jin, Juan Yin, Haie Xu, Chunfeng Xie, Caiyun Zhong   +10 more
doaj   +1 more source

Apatinib treatment efficiently delays biochemical-only recurrent ovarian cancer progression

, 2021
Background Biochemical recurrence is defined as only rising CA-125 but no radiographic evidence of disease; noteworthily, it generally precedes the onset of clinical evidence.
Yan Huang, Ling Long, Rongkai Xie, Li Zhou, Zhongyu Wang, Sufen Li, Yake Huang, Lei Gan, Aimin Pu   +8 more
core   +1 more source

Apatinib inhibits cell proliferation and migration of osteosarcoma via activating LINC00261/miR-620/PTEN axis

, 2021
Apatinib has been recently identified as a potential treatment option for osteosarcoma (OS). Nonetheless, the molecular mechanism of Apatinib in regulating OS progression remains unclear.
Meng Xu (62933), Jinpeng Jia (9155545), Wenzhi Bi (11320209), Ning Ma (155058), Gang Han (127634), Quanyi Guo (533713)   +5 more
core   +1 more source

Apatinib as targeted therapy for sarcoma [PDF]

Oncotarget, 2018
Sarcomas are a group of malignant tumors originating from mesenchymal tissue with a variety of cell subtypes. Despite several major treatment breakthroughs, standard treatment using surgery, radiation, and chemotherapy has failed to improve overall survival.
Li, Feng, Liao, Zhichao, Zhang, Chao, Zhao, Jun, Xing, Ruwei, Teng, Sheng, Zhang, Jin, Yang, Yun, Yang, Jilong   +8 more
openaire   +2 more sources

Drug-Eluting Bead Transarterial Chemoembolization versus Conventional Transarterial Chemoembolization Both Combined Apatinib for Hepatocellular Carcinoma: A Retrospective, Propensity-Score Matched Study

Journal of Hepatocellular Carcinoma, 2021
Tao Ouyang,1,* Junxia Liu,2,* Chengyang Shi,3 Lisheng Zhu,4 Xiaopeng Guo1 1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Cancer Medical Center ...
Ouyang T, Liu J, Shi C, Zhu L, Guo X
doaj  

Apatinib potentiates irradiation effect via suppressing PI3K/AKT signaling pathway in hepatocellular carcinoma

Journal of Experimental & Clinical Cancer Research, 2019
Background Limited effective intervention for advanced hepatocellular carcinoma (HCC) is available. This study aimed to investigate the potential clinical utility of apatinib, a highly selective inhibitor of the vascular endothelial growth factor ...
Junbin Liao, Huilin Jin, Shaoqiang Li, Lixia Xu, Zhenwei Peng, Guangyan Wei, Jianting Long, Yu Guo, Ming Kuang, Qi Zhou, Sui Peng   +10 more
doaj   +1 more source

Apatinib plus vinorelbine versus vinorelbine for metastatic triple-negative breast cancer who failed first/second-line treatment: the NAN trial

npj Breast Cancer, 2022
While therapies such as chemotherapy combined with immunotherapy, sacituzumab govitecan, and PARP inhibitors are available for metastatic TNBC, on disease progression after these therapies, the mainstay of therapy is chemotherapy.
Dou-Dou Li, Zhong-hua Tao, Bi-Yun Wang, Lei-Ping Wang, Jun Cao, Xi-Chun Hu, Jian Zhang   +6 more
doaj   +1 more source

Apatinib-loaded CalliSpheres Beads for embolization in a rabbit VX2 liver tumor: characterization in vitro, pharmacokinetics and tumor response in vivo

Drug Delivery, 2020
Apatinib mesylate is an oral antiangiogenic agent that can inhibit activation of vascular endothelial growth factor receptor-2 tyrosine kinase. However, its therapeutic use in liver cancer is restricted due to severe systemic toxicity.
Qin Shi, Yongning Lu, Songjiang Huang, Chen Zhou, Chongtu Yang, Jiacheng Liu, Jinqiang Ma, Bin Xiong   +7 more
doaj   +1 more source

Image1_Efficacy and Safety of Apatinib in Advanced Hepatocellular Carcinoma: A Multicenter Real World Retrospective Study.JPEG

, 2022
Background and Purpose: Apatinib is a novel antiangiogenic agent that can target vascular endothelial cell growth factor 2. The aim of our study was to evaluate the efficacy and safety of apatinib mesylate in the treatment of advanced hepatocellular ...
Jianfeng Wang (232744), Ying Xin (424597), Xiao Guo (542560), Lingbin Meng (675558), Zhuangzhuang Zheng (12553903), Haifeng Zhang (137541), Xiaojing Jia (616088), Zijing Liu (650545), Xin Jiang (6348)   +8 more
core   +1 more source

Efficacy and safety of apatinib alone or apatinib plus paclitaxel/docetaxel versus paclitaxel/docetaxel in the treatment of advanced non‐small cell lung cancer: A meta‐analysis

Thoracic Cancer, 2021
Background To investigate the efficacy and safety of apatinib alone or apatinib plus paclitaxel/docetaxel versus paclitaxel/docetaxel in the treatment of advanced non‐small cell lung cancer (NSCLC) through pooling of open published data.
Zhe Li, Zhibao Liu, Yuanyuan Wu, Huarui Li, Zhen Sun, Chenggang Han, Xiaoling Zhang, Jinghua Zhang   +7 more
doaj   +1 more source