Results 61 to 70 of about 7,987 (192)

Clinicogenomic Features and Outcomes of Adenoid Cystic Carcinoma With Central Nervous System Metastases: A Single‐Institution Cohort Study

Head &Neck, Volume 48, Issue 11, Page 3193-3201, November 2026.
ABSTRACT Background Adenoid cystic carcinoma (ACC) is a rare malignancy with a propensity for perineural invasion and hematogenous spread. Central nervous system (CNS) involvement is uncommon, and detailed clinical and genomic data on this aspect of the disease remain limited.
Omar Elghawy, Jack Stylli, Martin Kurian, Eitan Halper‐Stromberg, Aditi Singh, Christopher D'Avella, Lee Hartner, Roger B. Cohen   +7 more
wiley   +1 more source

Low-dose apatinib monotherapy in advanced chemotherapy-refractory small cell lung cancer: a case series and literature review

Journal of International Medical Research, 2020
The therapeutic regimen for small cell lung cancer (SCLC) has changed little in the past several decades. Apatinib is a small molecule inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase.
Ying-ying Liu, Tao Chen, Dan Shen, Wei-yun Zhang, Chang-guo Wang, Jun-hong Jiang, Da-xiong Zeng   +6 more
doaj   +1 more source

Association Between PDL1 Genetic Variation and Efficacy of Apatinib Monotherapy in Patients with Previously Treated Advanced NSCLC: A Real-World Retrospective Study

, 2021
Wenxia Hu, Bin Li, Nan Geng, Xin He, Hui Ge, Ping Wang, Cuimin Ding Department of Respiratory Medicine, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, People’s Republic of ChinaCorrespondence: Cuimin DingDepartment of Respiratory
Wang P, Ding C, Hu W, He X, Ge H, Li B, Geng N   +6 more
core  

Application of physiologically-based pharmacokinetic/pharmacodynamic models to evaluate the interaction between nifedipine and apatinib

Frontiers in Pharmacology, 2022
Aim: It has been found that the co-administration of nifedipine with apatinib could cause exposure changes of nifedipine in vivo. But, whether this pharmacokinetic drug-drug interaction (DDI) between nifedipine and apatinib could enhance the ...
Hongrui Liu, Yiqun Yu, Lu Liu, Chunyan Wang, Nan Guo, Xiaojuan Wang, Xiaoqiang Xiang, Xiaoqiang Xiang, Bing Han   +8 more
doaj   +1 more source

Progress in the Mechanism of Heat Shock Proteins in Gastric Cancer: From Biomarkers to Therapeutic Targets

Immunity, Inflammation and Disease, Volume 14, Issue 10, October 2026.
ABSTRACT Background Gastric cancer remains a major challenge in public health, with low early diagnosis rates and poor prognosis for advanced patients. Heat shock proteins (HSPs) are highly conserved molecular chaperones that maintain proteostasis and promote cell survival under stress.
Wang Yanan, Zhang Jinpeng, Zhou Peng, Wang Yuan, Wang Qingyi, Liang Guoying   +5 more
wiley   +1 more source

Apatinib promotes autophagy and apoptosis through VEGFR2/STAT3/BCL-2 signaling in osteosarcoma

, 2017
The cure rate of osteosarcoma has not improved in the past 30 years. The search for new treatments and drugs is urgently needed. Apatinib is a high selectivity inhibitor of vascular endothelial growth factor receptor-2 (VEGFR2) tyrosine kinase, exerting ...
Shidong Wang, Tingting Ren, Yi Huang, Wei Guo, Kunkun Sun, Kuisheng Liu, Xing Bao, Bingxin Zheng   +7 more
core   +1 more source

Efficacy and Safety of Apatinib in Patients with Recurrent Glioblastoma

, 2023
Background and Objective Glioblastoma is a cranial malignant tumor with a high recurrence rate after surgery and a poor response to chemoradiotherapy.
Hao Lin, Xinli Zhou, Xiaohua Liang, Xiaofang Sheng   +3 more
core   +1 more source

WZB117 enhanced the anti-tumor effect of apatinib against melanoma via blocking STAT3/PKM2 axis

Frontiers in Pharmacology, 2022
Background: Melanoma is the most lethal skin malignant tumor with a short survival once stepping into the metastatic status and poses a therapeutic challenge. Apatinib (a tyrosine kinase inhibitor) is a promising antiangiogenic agent for the treatment of
Ren-Shu Zhang, Zhi-Ke Li, Zhi-Ke Li, Jie Liu, Yao-Tiao Deng, Yu Jiang   +5 more
doaj   +1 more source

Association of Apatinib and Breast Cancer: A systematic review and meta-analysis

, 2022
Background: Breast cancer (BC) is a common malignant tumor. Apatinib in combination with other treatments has been used for BC; however, its safety and efficacy are not well-known.
Liang, Qiwei, Cheng, Ce, Mingming Liang, Qin Zhou, Guo, Xianwei, Rachel Bentley, Chenyu Sun, Wanying Su, Song, Qiuxia, Liang, Mingming, Ce Cheng, Li, Ning, Zhu, Yike, Zhou, Zhen, Scott Lowe, Lowe, Scott, Hao Wang, Qiwei Liang, Qiuxia Song, Zhou, Qin, Ning Li, Zhen Zhou, Xianwei Guo, Yike Zhu, Su, Wanying, Sun, Chenyu, Wang, Hao, Bentley, Rachel   +27 more
core   +2 more sources

Apatinib Mesylate Inhibits the Proliferation and Metastasis of Epithelioid Malignant Peritoneal Mesothelioma In Vitro and In Vivo

Frontiers in Oncology, 2020
ObjectiveMalignant peritoneal mesothelioma (MPM) is a rare malignancy with few effective molecular therapies. In this study, we evaluated the anti-tumor activity and safety of apatinib, a vascular endothelial growth factor receptor 2 inhibitor, in MPM in
Zhi-Ran Yang, Zhi-Gao Chen, Xue-Mei Du, Yan Li, Yan Li   +4 more
doaj   +1 more source