Results 111 to 120 of about 23,711 (313)
Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases
Cell Proliferation, EarlyView.HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang +4 more
wiley +1 more source
Apelin Protects Primary Rat Retinal Pericytes from Chemical Hypoxia-Induced Apoptosis
Journal of Ophthalmology, 2015 Pericytes are a population of cells that participate in normal vessel architecture and regulate permeability. Apelin, as the endogenous ligand of G protein-coupled receptor APJ, participates in a number of physiological and pathological processes.
Li Chen +3 more
doaj +1 more source
Apelin-13 inhibits large-conductance Ca2+-activated K+ channels in cerebral artery smooth muscle cells via a PI3-kinase dependent mechanism. [PDF]
PLoS ONE, 2013 Apelin-13 causes vasoconstriction by acting directly on APJ receptors in vascular smooth muscle (VSM) cells; however, the ionic mechanisms underlying this action at the cellular level remain unclear.
Amit Modgil +3 more
doaj +1 more source
Unlocking the Therapeutic Potential of Apelin [PDF]
Hypertension, 2016 See related article, pp 365–377 Apelin was identified in 1998 as the endogenous ligand for the then orphan G-protein–coupled receptor, APJ, now renamed the apelin receptor. Widely expressed in the central nervous system and peripheral tissues, the apelin system participates in a diverse array of processes, including glucose metabolism, immune ...
Alan G. Japp, David E. Newby
openaire +3 more sources
Inflammation and mechanical force‐induced bone remodeling
Periodontology 2000, EarlyView.Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon +6 more
wiley +1 more source
Apelin promotes lymphangiogenesis and lymph node metastasis [PDF]
, 2015 Whereas the role of the G-protein-coupled APJ receptor and its ligand, apelin, in angiogenesis has been well documented, the ability of the apelin/APJ system to induce lymphangiogenesis and lymphatic metastasis has been largely unexplored.
Berger W +15 more
core
Tumor apelin, not serum apelin, is associated with the clinical features and prognosis of gastric cancer [PDF]
BMC Cancer, 2016 To study the association between Apelin expression and the clinical features and postoperative prognosis in patients with gastric cancer (Int J Cancer 136:2388-2401, 2015).Tumor samples and matched adjacent normal tissues were collected from 270 patients with GC receiving surgical resection.
Hong-wei Yu +4 more
openaire +3 more sources
Targeting the elabela/apelin-apelin receptor axis as a novel therapeutic approach for hypertension
Chinese Medical Journal, 2021 Abstract Hypertension is the leading risk factor for global mortality and morbidity and those with hypertension are more likely to develop severe symptoms in cardiovascular and cerebrovascular system, which is closely related to abnormal renin-angiotensin system and elabela/apelin-apelin receptor (APJ) axis.
Jiawei Song +6 more
openaire +4 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Illustration of cellular and molecular cross‐talk in atrial fibrillation. Left: a schematic of cardiac tissue showing cardiomyocytes, fibroblasts, adipocytes, inflammatory cells and the coagulation system. Right: direct and indirect cross‐talk between different cell types, with the impact of direct cross‐talk on action potential (
Zhenyu Dong +2 more
wiley +1 more source
Sequences within the C terminus of the metabotropic glutamate receptor 5 (mGluR5) are responsible for inner nuclear membrane localization [PDF]
, 2017 Traditionally, G-protein-coupled receptors (GPCR) are thought to be located on the cell surface where they transmit extracellular signals to the cytoplasm.
Harmon, Steven K. +4 more
core +2 more sources