Results 91 to 100 of about 12,228 (219)

Expanded insight into processing and isoform dependent properties of apelin

, 2017
Apelin is one of two peptide ligands for a class A G-protein-coupled receptor (the apelin receptor; AR/APJ). Apelin-AR signalling regulates many body systems, including the cardiovascular system, central nervous system, and adipoinsular axis.
Shin, Kyungsoo
core  

Altered glucose homeostasis is associated with increased serum apelin levels in type 2 diabetes mellitus.

PLoS ONE, 2012
BackgroundApelin is an adipokine that plays a role in the regulation of glucose homeostasis and in obesity. The relationship between apelin serum concentration and dysmetabolic conditions such as type 2 diabetes (T2D) is still controversial.
Maria Gisella Cavallo, Federica Sentinelli, Ilaria Barchetta, Carmine Costantino, Michela Incani, Laura Perra, Danila Capoccia, Stefano Romeo, Efisio Cossu, Frida Leonetti, Luciano Agati, Marco G Baroni   +11 more
doaj   +1 more source

Electrical Pulse Stimulation Partially Restores Insulin Signaling in Palmitate‐Induced Insulin‐Resistant Skeletal Muscle Cells via Mitochondrial Remodeling and Contractile Activity‐Dependent Secretome

Journal of Cellular Physiology, Volume 241, Issue 10, October 2026.
ABSTRACT Lipid oversupply induces insulin resistance in skeletal muscle (SkM), partly by altering mitochondrial function and dynamics. Although electrical pulse stimulation (EPS) improves insulin signaling in myotubes, the mechanisms contributing to this effect under lipotoxic conditions remain unclear.
Falcone Alessandro, Yilmaz Sevgican, Hendlinger Mona, Schrauwen Patrick, Lipaeva Polina, Piribauer Marlene, Heilmann Geronimo, Trenkamp Sandra, Roden Michael, Mastrototaro Lucia   +9 more
wiley   +1 more source

Apelin-36-[L28A] and Apelin-36-[L28C(30kDa-PEG)] peptides that improve diet induced obesity are G protein biased ligands at the apelin receptor.

, 2019
BACKGROUND: Apelin signalling pathways have important cardiovascular and metabolic functions. Recently, apelin-36-[L28A] and apelin-36-[L28C(30kDa-PEG)], were reported to function independent of the apelin receptor in vivo to produce beneficial metabolic

core   +2 more sources

Pancreatic Cancer Disrupts Circadian Patterns of Gene Expression in Cardiorespiratory Muscles

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Cancer cachexia, a debilitating syndrome characterized by muscle wasting, significantly impacts survival in gastrointestinal cancers like pancreatic cancer. Emerging evidence suggests a link between cancer cachexia and disrupted circadian rhythms in peripheral tissues, including locomotor muscles. However, circadian dysregulation in
Jeremy B. Ducharme, Martin M. Schonk, Miguel A. Gutierrez‐Monreal, Leonardo F. Ferreira, Karyn A. Esser, Andrew R. Judge, Sarah M. Judge   +6 more
wiley   +1 more source

Exploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Urolithin A (UA) and urolithin B (UB) are gut microbiota‐derived metabolites of ellagitannins reported to influence mitochondrial function, inflammation and muscle metabolism. Their comparative transcriptomic effects in human skeletal muscle cells remain undefined.
Yves Henrotin, Antoine Florin, Christelle Sanchez, Prescilia Centonze, Tiago Pinto Coelho, Sophie Bekisz, Jean‐Emile Dubuc, Olivier Galand, Cécile Lambert   +8 more
wiley   +1 more source

Apelin [PDF]

, 2020
Marta Podgórska, Katarzyna Pietraszek-Gremplewicz, Dorota Nowak   +2 more
openaire   +2 more sources

Apelin increases cardiac contractility via protein kinase Cε- and extracellular signal-regulated kinase-dependent mechanisms.

PLoS ONE, 2014
BackgroundApelin, the endogenous ligand for the G protein-coupled apelin receptor, is an important regulator of the cardiovascular homoeostasis.
Ábel Perjés, Réka Skoumal, Olli Tenhunen, Attila Kónyi, Mihály Simon, Iván G Horváth, Risto Kerkelä, Heikki Ruskoaho, István Szokodi   +8 more
doaj   +1 more source

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley   +1 more source

RUNX3-activated apelin signaling inhibits cell proliferation and fibrosis in diabetic nephropathy by regulation of the SIRT1/FOXO pathway

Diabetology & Metabolic Syndrome
Background Diabetic nephropathy is a major secondary cause of end-stage renal disease. Apelin plays an important role in the development of DN. Understanding the exact mechanism of Apelin can help expand the means of treating DN.
Xin Zhong, Jun Zhang
doaj   +1 more source