Results 81 to 90 of about 12,228 (219)

Sodium–glucose cotransporter 2 inhibitors for hypertension in cardiovascular–kidney–metabolic syndrome

Experimental Physiology, EarlyView.
Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu, Xingyu Qiu, Nan Xu, Gensheng Zhang, Enyin Lai, Liang Zhao   +5 more
wiley   +1 more source

Apelin is a novel islet peptide. [PDF]

, 2010
International audienceApelin, a recently discovered peptide with wide tissue distribution, regulates feeding behavior, improves glucose utilization, and inhibits insulin secretion.
Wierup, Nils, Rehfeld, Jens, F., Rehfeld, Jens F., Friis-Hansen, Lennart, Rehfeld, Jens F, Bennet, Hedvig, Ringström, Camilla, Fex, Malin, Nitert, Marloes Dekker, Valet, Philippe, Dekker Nitert, Marloes, Friis-Hansen, Lennart Jan   +11 more
core   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, Volume 14, Issue 8, Page 2401-2418, November 2026.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

Effects of Weight Loss and Exercise on Apelin Serum Concentrations and Adipose Tissue Expression in Human Obesity

Obesity Facts, 2013
Objective: Apelin is an adipokine which plays a role in the regulation of glucose homeostasis and may contribute to the link between increased adipose tissue mass and obesity related metabolic diseases.
Joanna Krist, Katharina Wieder, Nora Klöting, Andreas Oberbach, Susan Kralisch, Tobias Wiesner, Michael R. Schön, Daniel Gärtner, Arne Dietrich, Edward Shang, Tobias Lohmann, Miriam Dreßler, Mathias Fasshauer, Michael Stumvoll, Matthias Blüher   +14 more
doaj   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Apelin Role in the Development of Glucose Metabolism Disorders (Review of the Literature and Our Own Researches)

Mìžnarodnij Endokrinologìčnij Žurnal, 2014
The physiological and pathogenetic role of adipokine apelin, endogenous ligand of apelin (APJ or APLNR) receptors in the development of glucose metabolism disorders has been analyzed.
G.V. Demidenko
doaj   +1 more source

Multi‐omics integration and machine learning identify an ACKR1+ endothelial cell‐based lactate‐immune signature associated with carotid plaque vulnerability and progression

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
ACKR1+ endothelial cells mark intraplaque neovessels with hyperactive glycolysis and lactate metabolism. Lactate, HIF‐1α and CXCL12 link this state to CXCR4+ CD8+ T‐cell recruitment in situ. SLC16A3 and SLC16A4 serve as quantitative readouts of this lactate–immune state.
Ji Zhang, Qijian Zhao, Yufei Wu, Keqiang Shu, Junye Chen, Kang Li, Yuyao Feng, Xu Zhang, Wenjian Liu, Zhichao Lai, Bao Liu   +10 more
wiley   +1 more source

Apelin Enhances the Effects of Fusobacterium nucleatum on Periodontal Ligament Cells In Vitro [PDF]

, 1988
This study aimed to explore effects of Fusobacterium nucleatum with or without apelin on periodontal ligament (PDL) cells to better understand pathomechanistic links between periodontitis and obesity. First, the actions of F. nucleatum on COX2, CCL2, and
Hiçyılmaz, Gülbin, Nogueira, Andressa V. B., Nurcan Buduneli, Gutierrez, Lorena S. [UNESP], Gutierrez, Lorena S, Lorena S. Gutierrez, Nogueira, Andressa V B, Buduneli, Nurcan, Deschner, James, Weusmann, Jens, Jens Weusmann, James Deschner, Pablo Cores Ziskoven, Sigrun Eick, Cores Ziskoven, Pablo, Andressa V. B. Nogueira, Eick, Sigrun   +16 more
core   +2 more sources

Apelin enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly through Wnt/β-catenin signaling pathway

Stem Cell Research & Therapy, 2019
Background Management of fracture healing with a large bone defect remains a tricky subject in orthopedic trauma. Enhancing osteogenesis of human bone marrow-derived mesenchymal stem cells (hBMSCs) is one of the useful therapeutic strategies for fracture
Kai Hang, Chenyi Ye, Jianxiang Xu, Erman Chen, Cong Wang, Wei Zhang, Lic Ni, Zhih Kuang, Li Ying, Deting Xue, Zhijun Pan   +10 more
doaj   +1 more source

Role of Triceps Muscle Fiber‐Specific Myokines in Pancreatic β‐Cell Protection: Implications for Type 2 Diabetes: A Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims Type 2 diabetes (T2D) is a major global health challenge, primarily driven by insulin resistance and progressive β‐cell dysfunction aggravated by chronic low‐grade inflammation. Skeletal muscle has emerged as a pivotal endocrine organ through the secretion of myokines, which exert systemic metabolic and immunomodulatory ...
Christian Tague, Dujardin Makeda, Hermann Yokolo, Joshua Ekouo   +3 more
wiley   +1 more source