Results 71 to 80 of about 12,228 (219)

Hypoxia exposure alleviates impaired muscular metabolism, glucose tolerance, and aerobic capacity in apelin-knockout mice

, 2019
High altitude hypoxia adaptation can improve glucose tolerance in people with metabolic syndrome and type 2 diabetes (T2D). Apelin is an endogenous ligand of the G protein-coupled receptor APJ and has possible roles in energy metabolism. Apelin-null mice
He, Shiyi, Li, Junping, Zhang, Ying, Wang, Jianxiong   +3 more
core   +1 more source

Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension

JACC: Basic to Translational Science, 2018
Summary: Apelin agonism causes systemic vasodilatation and increased cardiac contractility in humans, and improves pulmonary arterial hypertension (PAH) in animal models. Here, the authors examined the short-term pulmonary hemodynamic effects of systemic
Lauren Brash, MD, Gareth D. Barnes, MD, Melanie J. Brewis, MD, A. Colin Church, MD, Simon J. Gibbs, MD, Luke S.G.E. Howard, MD, Geeshath Jayasekera, MBChB, Martin K. Johnson, MD, Neil McGlinchey, MBChB, Joelle Onorato, PhD, Joanne Simpson, MD, Colin Stirrat, MD, Stephen Thomson, MBChB, Geoffrey Watson, MD, Martin R. Wilkins, MD, Carrie Xu, MS, David J. Welsh, PhD, David E. Newby, MD, Andrew J. Peacock, MD   +18 more
doaj   +1 more source

The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target

Frontiers in Neurology, 2020
The orphan receptor APJ and its endogenous ligand apelin, which are expressed in the brain, are the major components of the apelin/APJ system. Growing evidence shows that the apelin/APJ system plays a vital role in the pathophysiology of cerebral ...
Yanjun Tian, Ruijiao Chen, Yunlu Jiang, Yunlu Jiang, Bo Bai, Tongju Yang, Haiqing Liu   +6 more
doaj   +1 more source

Salivary Apelin Levels and Periodontal Findings in Individuals With/Without Type 1 Diabetes and Varying Degrees of Gingival Inflammation

Oral Diseases, EarlyView.
ABSTRACT Objective To evaluate salivary apelin levels in individuals with and without type 1 diabetes presenting an intact periodontium and varying degrees of plaque‐induced gingival inflammation. Methods Saliva samples were collected; and whole‐mouth clinical periodontal measurements were recorded in type 1 diabetes and systemically healthy ...
Demet Efe Yavaşoğlu, Andressa V. B. Nogueira, Mehmet Demirbaş, Timur Köse, Sebahat Kaya, James Deschner, Nurcan Buduneli   +6 more
wiley   +1 more source

Molecular profile of pediatric pseudotumor cerebri: the role of apelin isoforms and oxidative stress

BMC Pediatrics
Background Apelin is an endogenous ligand of the apelin receptor (APJ), expressed in multiple tissues, including the brain and heart. Isoforms such as apelin-13 and apelin-36 play protective roles in pathological processes, including oxidative stress ...
Peren Perk, Arzu Yuksel, Zeynep Oz Dagdelen, Sevinc Mertoglu, Merve Cakmak, Pakize Cennetoglu, Pınar Arıcan, Alper Gumus, Ihsan Kafadar   +8 more
doaj   +1 more source

Chronic apelin analogue administration is more effective than established incretin therapies for alleviating metabolic dysfunction in diabetic db/db mice [PDF]

, 2020
Stable apelin-13 peptide analogues have shown promising acute antidiabetic effects in mice with diet-induced obesity diabetes. Here the efficacy of (pGlu)apelin-13 amide (apelin amide) and the acylated analogue (pGlu)(Lys 8GluPAL)apelin-13 amide (apelin ...
Parthsarathy, Vadivel, V, Parthsarathy, O'Harte, Finbarr P M, Flatt, Peter R, O'Harte, Finbarr, Flatt, PR   +5 more
core   +1 more source

Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke

Frontiers in Pharmacology
The apelin/APJ system has garnered increasing attention in recent years. In this review, we comprehensively discuss the physiological and pathological mechanisms of the apelin/APJ system in stroke. The apelin/APJ system is widely expressed in the central
Weilin Xu, Weilin Xu, Jun Yan, Zachary D. Travis, Cameron Lenahan, Liansheng Gao, Liansheng Gao, Haijian Wu, Haijian Wu, Jingwei Zheng, Jingwei Zheng, Jianmin Zhang, Jianmin Zhang, Anwen Shao, Anwen Shao, Jun Yu, Jun Yu   +16 more
doaj   +1 more source

Apelin protects against NMDA-induced retinal neuronal death via an APJ receptor by activating Akt and ERK1/2, and suppressing TNF-α expression in mice

Journal of Pharmacological Sciences, 2017
Glutamate excitotoxicity mediated by N-methyl-d-aspartate (NMDA) receptors is an important cause of retinal ganglion cell death in glaucoma. To elucidate whether apelin protects against retinal neuronal cell death, we examined protective effects of ...
Yuki Ishimaru, Akihide Sumino, Daiki Kajioka, Fumiya Shibagaki, Akiko Yamamuro, Yasuhiro Yoshioka, Sadaaki Maeda   +6 more
doaj   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

The G protein‐coupled receptor ligand apelin‐13 ameliorates skeletal muscle atrophy induced by chronic kidney disease

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Targeting of the apelin–apelin receptor (Apj) system may serve as a useful therapeutic intervention for the management of chronic kidney disease (CKD)‐induced skeletal muscle atrophy.
Yuki Enoki, Tomoya Nagai, Yuna Hamamura, Sumika Osa, Hideaki Nakamura, Kazuaki Taguchi, Hiroshi Watanabe, Toru Maruyama, Kazuaki Matsumoto   +8 more
doaj   +1 more source