Pharmaceutics, 2023 The widely expressed G protein-coupled apelin receptor (APJ) is activated by two bioactive endogenous peptides, apelin and ELABELA (ELA). The apelin/ELA-APJ-related pathway has been found involved in the regulation of many physiological and pathological ...
Daniela Rossin +5 more
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Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke
Frontiers in PharmacologyThe apelin/APJ system has garnered increasing attention in recent years. In this review, we comprehensively discuss the physiological and pathological mechanisms of the apelin/APJ system in stroke. The apelin/APJ system is widely expressed in the central
Weilin Xu +16 more
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Apelin/APJ system: an emerging therapeutic target for neurological diseases
Molecular Biology Reports, 2022 Apelin, an endogenous ligand for the G protein-coupled receptor APJ, is extensively expressed in various systems, especially the nervous system. This article reviews the role of apelin/APJ system in neurological diseases. In detail, apelin/APJ system can
Zhiyue Li
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Advances in the therapeutic potentials of ligands of the apelin receptor APJ
European Journal of PharmacologyAngiotensin II protein J receptor, APJ, is a type A G protein coupled receptor. Endogenous apelin and elabela peptides stimulate APJ via distinct signalling profiles. A complex signalling map of elabela-stimulated APJ was published in 2022.
Gert N Moll
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The Apelin/APJ System in Psychosis and Neuropathy
Frontiers in Pharmacology, 2020 Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the G-protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely expressed in the central nervous system and peripheral tissues of humans and animals ...
Shuang-Yu Lv +3 more
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Relationship Between Serum Apelin-13 and Apelin Receptor Levels and the Severity of Disease in Patients Diagnosed with Obstructive Sleep Apnea Syndrome [PDF]
DiagnosticsBackground and Objectives: Apelin-13 and its receptor (APJ) are increasingly recognized as key regulators of metabolic pathways that may contribute to the pathophysiology of obstructive sleep apnea (OSA) syndrome.
Demet Aygun +5 more
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Radiographic Prevalence of Anatomical Variations of the Ventral Lamina of the Sixth Cervical Vertebra, C6/C7 Articular Process Joint Modelling and Competition Outcomes in Warmblood Sport Horses [PDF]
AnimalsAnatomical variations of the caudal ventral lamina of the sixth cervical vertebra (C6), referred to as equine caudal cervical morphologic variations (ECCMV), and radiographic modelling of the caudal cervical articular process joints (APJ) are commonly ...
Teresa Strootmann +2 more
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APJ regulates the balance between self-renewal and differentiation of vascular endothelial stem cells [PDF]
Inflammation and RegenerationBackground CD157 marks a population of tissue-resident vascular endothelial stem cells (VESCs) in mice known for their critical role in homeostatic endothelial cell (EC) turnover and the rapid response to vascular damage in the liver by regeneration ...
Man Wang +7 more
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The Apelin/APJ System: A Potential Therapeutic Target for Sepsis
Journal of Inflammation ResearchQing Song, Xi Wang,* Zhenhuan Cao,* Chun Xin,* Jingyuan Zhang,* Suwei Li Intensive Care Unit, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116000, People’s Republic of China*These authors contributed ...
Song Q +5 more
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Journal of Neuroinflammation, 2019 Background Neuroinflammation and oxidative stress play important roles in early brain injury following subarachnoid hemorrhage (SAH). This study is the first to show that activation of apelin receptor (APJ) by apelin-13 could reduce endoplasmic reticulum
Weilin Xu +6 more
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