Results 31 to 40 of about 23,200 (255)
Angiogenesis, 2023 APJ has been extensively described in the pathophysiology of angiogenesis and cell proliferation. The prognostic value of APJ overexpression in many diseases is now established. This study aimed to design a PET radiotracer that specifically binds to APJ.
Beatrice Louis +15 more
semanticscholar +1 more source
Apelin-APJ Signaling in Retinal Angiogenesis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2008 The G protein–coupled receptor (GPCR) APJ ( X-msr, angiotensin receptor like 1b ) was cloned in several laboratories by homology screening, with the goal of identifying new members of this class of cell surface receptor.1 This gene attracted attention because of its sequence similarity to the important angiotensin II type 1 receptor and its highly ...
Yoko, Kojima, Thomas, Quertermous
openaire +2 more sources
Redox Biology, 2020 The apelin and Elabela proteins constitute a spatiotemporal double-ligand system that controls apelin receptor (APJ) signal transduction. Phosphorylation of multiple sites within the C-terminus of APJ is essential for the recruitment of β-arrestins.
Jing Chen +9 more
doaj +1 more source
The regulatory effects of the apelin/APJ system on depression: A prospective therapeutic target.
Neuropeptides, 2023 Depression is a debilitating neuropsychological disorder characterized by high incidence, high recurrence, high suicide, and high disability rates, which poses serious threats to human health and imposes heavy psychological and economic burdens on family
Yanjun Tian +6 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2023 Introduction: Fast food is a major risk factor for atherosclerosis, a leading cause of morbidity and mortality in the Western world. Apelin, the endogenous adipokine, can protect against cardiovascular disease via activating its receptor, APJ ...
Azza H. Abdelwahab +7 more
doaj +1 more source
Roles of the Hepatic Endocannabinoid and Apelin Systems in the Pathogenesis of Liver Fibrosis
Cells, 2019 Hepatic fibrosis is the consequence of an unresolved wound healing process in response to chronic liver injury and involves multiple cell types and molecular mechanisms.
Pedro Melgar-Lesmes +2 more
doaj +1 more source
Ecofriendly building blocks using foamed concrete with ground granulated blast furnace slag
International Journal of Sustainable Engineering, 2021 The cost of construction has intensified very significantly in recent years, which is a great area of concern for all the stakeholders. Production of conventional bricks causes substantial depletion of natural resources and creates environmental ...
Sajan K. Jose +2 more
doaj +1 more source
Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2and cell proliferationviaGαq-mediated mechanism [PDF]
, 2014 Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling.
Cai, X +9 more
core +1 more source
changhoonhahn/provabgs: ApJ release
, 2022 Release accompanying ApJ ...
ChangHoon Hahn, Peter Melchior
core +1 more source
Frontiers in Physiology, 2021 The central site(s) mediating the cardiovascular actions of the apelin-apelin receptor (APJ) system remains a major question. We hypothesized that the sensory circumventricular organs (CVOs), interfacing between the circulation and deeper brain ...
Philip R. Griffiths +4 more
doaj +1 more source