Results 21 to 30 of about 23,200 (255)
Theranostics, 2023 Rationale: Ischemia-reperfusion injury (I/R) is a common cause of acute kidney injury (AKI). Post-ischemic recovery of renal blood supply plays an important role in attenuating injury. Exogenous application of elabela (ELA) peptides has been demonstrated
MingRui Xiong +12 more
semanticscholar +1 more source
Frontiers in Physiology, 2021 The apelin receptor (APJ) is a member of the family A of G-protein-coupled receptors (GPCRs) and is involved in range of physiological and pathological functions, including fluid homeostasis, anxiety, and depression, as well as cardiovascular and ...
Gonghui Hu +4 more
doaj +1 more source
Frontiers in Neurology, 2020 The orphan receptor APJ and its endogenous ligand apelin, which are expressed in the brain, are the major components of the apelin/APJ system. Growing evidence shows that the apelin/APJ system plays a vital role in the pathophysiology of cerebral ...
Yanjun Tian +6 more
doaj +1 more source
ELABELA/APJ Axis Prevents Diabetic Glomerular Endothelial Injury by Regulating AMPK/NLRP3 Pathway
Inflammation, 2023 ELABELA (ELA), a recently discovered peptide, is highly expressed in adult kidneys and the endothelium system. It has been identified as a novel endogenous ligand for the apelin receptor (APJ).
Zhi-Da Chen +14 more
semanticscholar +1 more source
The role of the apelin/APJ system in water homeostasis regulation
Ожирение и метаболизм, 2023 Water balance in the body is achieved by balancing renal and non-renal water losses with corresponding water intake. It is under the control of both the central nervous system, which integrates many parameters of water and electrolyte balance in the body,
Kh. R. Fargieva +3 more
doaj +1 more source
Life Science, 2023 Stroke can induce cardiac dysfunction without a primary cardiac disease. Exercise can promote the overall rehabilitation of stroke patients and be beneficial for all kinds of heart diseases.
Li Wang +11 more
semanticscholar +1 more source
The Effects of Apelin and Elabela Ligands on Apelin Receptor Distinct Signaling Profiles
Frontiers in Pharmacology, 2021 Apelin and Elabela are endogenous peptide ligands for Apelin receptor (APJ), a widely expressed G protein-coupled receptor. They constitute a spatiotemporal dual ligand system to control APJ signal transduction and function.
Yunlu Jiang +11 more
doaj +1 more source
FloorBroekgaarden/MRR_Project: ApJ accepted paper version
, 2022 Version of the Github code that was used for making all results and plots in the ApJ accepted version of this paper The code archived here reproduces all plots and results from the paper "Signatures of mass ratio reversal in gravitational waves from ...
Floor Broekgaarden
core +1 more source
Targeting the elabela/apelin-apelin receptor axis as a novel therapeutic approach for hypertension
Chinese Medical Journal, 2022 . Hypertension is the leading risk factor for global mortality and morbidity and those with hypertension are more likely to develop severe symptoms in cardiovascular and cerebrovascular system, which is closely related to abnormal renin-angiotensin ...
Jiawei Song +6 more
doaj +1 more source
Nature Communications, 2022 Type 2 diabetes mellitus is one of the most prevalent metabolic diseases presenting with systemic pathologies, including reproductive disorders in male diabetic patients.
Ke Song +18 more
semanticscholar +1 more source