Results 1 to 10 of about 7,162 (112)

Expanding the apelin receptor pharmacological toolbox using novel fluorescent ligands [PDF]

Frontiers in Endocrinology, 2023
IntroductionThe apelin receptor binds two distinct endogenous peptides, apelin and ELA, which act in an autocrine/paracrine manner to regulate the human cardiovascular system.
Thomas L. Williams, Robyn G. C. Macrae, Robyn G. C. Macrae, Rhoda E. Kuc, Alastair J. H. Brown, Janet J. Maguire, Anthony P. Davenport   +6 more
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Structural and functional determination of peptide versus small molecule ligand binding at the apelin receptor [PDF]

Nature Communications
We describe a structural and functional study of the G protein-coupled apelin receptor, which binds two endogenous peptide ligands, apelin and Elabela/Toddler (ELA), to regulate cardiovascular development and function.
Thomas L. Williams, Grégory Verdon, Rhoda E. Kuc, Heather Currinn, Brian Bender, Nicolae Solcan, Oliver Schlenker, Robyn G. C. Macrae, Jason Brown, Marco Schütz, Andrei Zhukov, Sanjay Sinha, Chris de Graaf, Stefan Gräf, Janet J. Maguire, Alastair J. H. Brown, Anthony P. Davenport   +16 more
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The Effects of Apelin and Elabela Ligands on Apelin Receptor Distinct Signaling Profiles [PDF]

Frontiers in Pharmacology, 2021
Apelin and Elabela are endogenous peptide ligands for Apelin receptor (APJ), a widely expressed G protein-coupled receptor. They constitute a spatiotemporal dual ligand system to control APJ signal transduction and function.
Yunlu Jiang, Maocai Yan, Chunmei Wang, Qinqin Wang, Xiaoyu Chen, Rumin Zhang, Lei Wan, Bingyuan Ji, Bo Dong, Huiyun Wang, Jing Chen, Jing Chen   +11 more
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Targeting the elabela/apelin-apelin receptor axis as a novel therapeutic approach for hypertension [PDF]

Chinese Medical Journal, 2022
. Hypertension is the leading risk factor for global mortality and morbidity and those with hypertension are more likely to develop severe symptoms in cardiovascular and cerebrovascular system, which is closely related to abnormal renin-angiotensin ...
Jiawei Song, Jianqiong Tang, Zhenzhou Zhang, Ying Liu, Jiuchang Zhong, Ningning Wang, Peifang Wei   +6 more
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The Role of Apelin/Apelin Receptor in Energy Metabolism and Water Homeostasis: A Comprehensive Narrative Review [PDF]

Frontiers in Physiology, 2021
The apelin receptor (APJ) is a member of the family A of G-protein-coupled receptors (GPCRs) and is involved in range of physiological and pathological functions, including fluid homeostasis, anxiety, and depression, as well as cardiovascular and ...
Gonghui Hu, Zhen Wang, Rumin Zhang, Wenping Sun, Xiaoyu Chen   +4 more
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Apelin–APLNR pathway across development, inflammation, and vascular remodeling: an endothelial perspective [PDF]

Experimental and Molecular Medicine
The apelinergic system, composed of the ligands Apelin and Elabela and their shared receptor APLNR, has key functions in vascular development and endothelial homeostasis.
Hongryeol Park, Ralf H. Adams, Kee-Pyo Kim   +2 more
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Apelin and its Receptor: An Overview [PDF]

Journal of Clinical and Diagnostic Research, 2019
Apelin protein is an endogenous ligand of Apelin Receptor (APJ). APJ is a member of G-protein coupled receptor family. Both apelin and its receptor express extensively in the human body.
Rajeev Gandham, ME Sumathi, CD Dayanand, SR Sheela, P Kiranmayee   +4 more
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Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation

eLife, 2023
We sought to define the mechanism underlying lung microvascular regeneration in a model of severe acute lung injury (ALI) induced by selective lung endothelial cell ablation. Intratracheal instillation of DT in transgenic mice expressing human diphtheria
Rafael Soares Godoy, Nicholas D Cober, David P Cook, Emma McCourt, Yupu Deng, Liyuan Wang, Kenny Schlosser, Katelynn Rowe, Duncan J Stewart   +8 more
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Apelin Does Not Impair Coronary Artery Relaxation Mediated by Nitric Oxide-Induced Activation of BKCa Channels

Frontiers in Pharmacology, 2021
Apelin-APJ receptor signaling regulates vascular tone in cerebral and peripheral arteries. We recently reported that apelin inhibits BKCa channel function in cerebral arteries, resulting in impaired endothelium-dependent relaxations.
Amreen Mughal, Chengwen Sun, Stephen T. O’Rourke   +2 more
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Can Dietary n-3 Polyunsaturated Fatty Acids Affect Apelin and Resolvin in Testis and Sperm of Male Rabbits?

Molecules, 2023
Apelin and other novel adipokines have been associated with normal and pathological reproductive conditions in humans and animals. In this paper, we used a rabbit model to investigate if apelin and resolvin (RvD1) in testis and sperm are associated with ...
Simona Mattioli, Elena Moretti, Cesare Castellini, Cinzia Signorini, Roberta Corsaro, Elisa Angelucci, Giulia Collodel   +6 more
doaj   +1 more source