Results 31 to 40 of about 7,237 (173)
Bioactivity of the putative apelin proprotein expands the repertoire of apelin receptor ligands [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2017 Apelin is a peptide ligand for a class A G-protein coupled receptor called the apelin receptor (AR or APJ) that regulates angiogenesis, the adipoinsular axis, and cardiovascular functions. Apelin has been shown to be bioactive as 13, 17, and 36 amino acid isoforms, C-terminal fragments of the putatively inactive 55-residue proprotein (proapelin or ...
Kyungsoo Shin +8 more
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The Effect of Troxerutin on Apelin-13 and Its Receptor Gene Expression in Ovarian of Pregnant Rats Fed a High-fat diet [PDF]
Journal of Advanced Biomedical Sciences, 2021 Background & Objective: Apelin is a newly discovered member of adipocytokines that acts as an endogenous ligand for the G-coupled receptor for the protein orphan (APJ). This study aimed at investigating the beneficial effect of troxerutin (TRO) on apelin-
Keyvan Mehri, Shirin Babri
doaj
Medicine Science, 2014 Prostate cancer is one of the most prevalent type of cancer in men. The exact solution for the treatment of different types of cancers has not been fully elucideted.
Suat Tekin, Suleyman Sandal, Cemil Colak
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Frontiers in Pharmacology, 2020 Apelin is the endogenous ligand for APJ, a G-protein-coupled receptor. Apelin gene and protein are widely distributed in the central nervous system and peripheral tissues. The role of apelin in chronic inflammatory pain is still unclear.
Shuangyu Lv +5 more
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The Role of the Apelin/APJ System in the Regulation of Liver Disease
Frontiers in Pharmacology, 2017 Apelin is an endogenous peptide that is a ligand for the APJ receptor (angiotensin II receptor like-1, AT-1). The apelin/APJ system is distributed in diverse periphery organ tissues.
Wei-Dong Chen +4 more
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Frontiers in Pharmacology, 2021 Signaling through the apelin receptor is beneficial for a number of diseases including pulmonary arterial hypertension. The endogenous small peptides, apelin and elabela/toddler, are downregulated in pulmonary arterial hypertension but are not suitable ...
Cai Read +10 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on APLNR (apelin receptor), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire +2 more sources
ASN Neuro, 2015 Apelin is a peptide originally isolated from bovine stomach tissue extracts and identified as an endogenous ligand of the APJ receptor; recent work showed that apelin ameliorates the ischemic injury in the heart and the brain.
Dongdong Chen +4 more
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Journal of Pharmacological Sciences, 2017 Glutamate excitotoxicity mediated by N-methyl-d-aspartate (NMDA) receptors is an important cause of retinal ganglion cell death in glaucoma. To elucidate whether apelin protects against retinal neuronal cell death, we examined protective effects of ...
Yuki Ishimaru +6 more
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Apelin enhances directed cardiac differentiation of mouse and human embryonic stem cells. [PDF]
PLoS ONE, 2012 Apelin is a peptide ligand for an orphan G-protein coupled receptor (APJ receptor) and serves as a critical gradient for migration of mesodermal cells fated to contribute to the myocardial lineage.
I-Ning E Wang +11 more
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