Results 11 to 20 of about 7,237 (173)

Evaluation of Apelin and Apelin Receptor Level in the Primary Tumor and Serum of Colorectal Cancer Patients [PDF]

Journal of Clinical Medicine, 2019
Colorectal cancer is the second deadliest tumor, which has a positive correlation with obesity which led to increasing interest in the relationship between adipokines and cancer progression. Apelin is a secreted peptide involved in regulation of tumor progression and invasiveness.
Dorota Diakowska, Katarzyna Pietraszek-Gremplewicz, Dorota Nowak   +2 more
exaly   +5 more sources

On Methods for the Measurement of the Apelin Receptor Ligand Apelin. [PDF]

Sci Rep, 2022
AbstractApelin exists in many isoforms, both in the circulation and in specific tissues. Apelin peptides have a short half-life but preservation before measurement is scarcely studied. Reproducible mass spectrometry methods to specifically measure a broad range of apelinergic peptide isoforms are currently lacking.
Janssens P, de Loor H, Decuypere JP, Vennekens R, Llorens-Cortes C, Mekahli D, Bammens B.   +6 more
europepmc   +5 more sources

(-)-Epicatechin Is a Biased Ligand of Apelin Receptor. [PDF]

Int J Mol Sci, 2022
(-)-Epicatechin (EC) is part of a large family of biomolecules called flavonoids and is widely distributed in the plant kingdom. Several studies have shown the beneficial effects of EC consumption. Many of these reported effects are exerted by activating the signaling pathways associated with the activation of two specific receptors: the G protein ...
Portilla-Martínez A, Ortiz-Flores MÁ, Meaney E, Villarreal F, Nájera N, Ceballos G.   +5 more
europepmc   +3 more sources

Immunohistochemistry and molecular biology studies of apelin and apelin receptor in queen placenta. [PDF]

Vet Res Commun
Abstract Placenta is a tissue where vasculogenesis, blood pressure and blood flow are dramatically important to allow normal embryonic and foetal growth and requires the production of numerous growth factors, hormones and transcription factors.
Pastore S, Dall'Aglio C, Maranesi M, Robiteau G, Zappone V, Caspanello T, Fontbonne A, Polisca A, Supplizi AV, Troisi A.   +9 more
europepmc   +3 more sources

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Apelin Receptor Dimerization and Oligomerization

Current Molecular Pharmacology, 2023
Abstract: Apelin and its receptor are expressed in many tissues and play an important role in maintaining the homeostasis of the cardiovascular system and body fluids. Also, the association of this system with many diseases, such as diabetes, hypertension, obesity, cancer, diabetic retinopathy, etc., has been determined.
Mahboobeh Yeganeh-Hajahmadi, Yasmin Moosavi-Saeed, Farzaneh Rostamzadeh   +2 more
openaire   +2 more sources

Intravenous Administration of Pyroglutamyl Apelin-13 Alleviates Murine Inflammatory Pain via the Kappa Opioid Receptor

Frontiers in Neuroscience, 2020
Apelin is an endogenous neuropeptide, which has wide distribution in central nervous system and peripheral tissues. Pyroglutamyl apelin-13 [(pyr)apelin-13] is the major apelin isoform in human plasma.
Shuangyu Lv, Xiaomei Zhang, Yu Feng, Yuchen Zhou, Binbin Cui, Yanjie Yang, Xinchun Wang   +6 more
doaj   +1 more source

Apelin ameliorates TNF-α-induced reduction of glycogen synthesis in the hepatocytes through G protein-coupled receptor APJ. [PDF]

PLoS ONE, 2013
Apelin, a novel adipokine, is the specific endogenous ligand of G protein-coupled receptor APJ. Consistent with its putative role as an adipokine, apelin has been linked to states of insulin resistance.
Jiaojiao Chu, Hangxiang Zhang, Xiuqing Huang, Yajun Lin, Tao Shen, Beidong Chen, Yong Man, Shu Wang, Jian Li   +8 more
doaj   +1 more source

Study Progression of Apelin/APJ Signaling and Apela in Different Types of Cancer

Frontiers in Oncology, 2021
Apelin is an endogenous ligand that binds to the G protein-coupled receptor angiotensin-like-receptor 1 (APJ). Apelin and APJ are widely distributed in organs and tissues and are involved in multiple physiological and pathological processes including ...
Longfei Liu, Xiaoping Yi, Can Lu, Yong Wang, Qiao Xiao, Liang Zhang, Yingxian Pang, Xiao Guan   +7 more
doaj   +1 more source

Apelin and apelin receptor expression in renal cell carcinoma. [PDF]

Br J Cancer, 2019
The APLNR (apelin receptor) has been shown to be an essential gene for cancer immunotherapy, with deficiency in APLNR leading to immunotherapy failure. The aim of this study is to investigate the expression of APLN (apelin) and APLNR in patients with renal cell carcinoma (RCC), and its association with clinicopathological parameters and survival.Three ...
Tolkach Y, Ellinger J, Kremer A, Esser L, Müller SC, Stephan C, Jung K, Toma M, Kristiansen G, Hauser S.   +9 more
europepmc   +4 more sources