Results 21 to 30 of about 7,237 (173)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

The Role of Apelin–APJ System in Diabetes and Obesity

Frontiers in Endocrinology, 2022
Nowadays, diabetes and obesity are two main health-threatening metabolic disorders in the world, which increase the risk for many chronic diseases. Apelin, a peptide hormone, exerts its effect by binding with angiotensin II protein J receptor (APJ) and ...
Cheng Li, Hongna Cheng, Binay Kumar Adhikari, Shudong Wang, Na Yang, Wenyun Liu, Jian Sun, Yonggang Wang   +7 more
doaj   +1 more source

The Role of Apelin and Apelin Receptor Expression in Migration and Invasiveness of Colon Cancer Cells [PDF]

Anticancer Research, 2021
Colon cancer is the second deadliest malignancy for human. Its correlation with obesity has led to an increasing number of studies focusing on the role of adipokines in colon cancer development. Apelin, which belongs to the family of adipokines, affects several pathological processes, including heart diseases, obesity and carcinogenesis. In this study,
Marta, PodgÓrska, Katarzyna, Pietraszek-Gremplewicz, Joanna, OlszaŃska, Dorota, Nowak   +3 more
openaire   +2 more sources

Diuretic Action of Apelin-13 Mediated by Inhibiting cAMP/PKA/sPRR Pathway

Frontiers in Physiology, 2021
Emerging evidence is showing that apelin plays an important role in regulating salt and water balance by counteracting the antidiuretic action of vasopressin (AVP). However, the underlying mechanism remains unknown. Here, we hypothesized that (pro) renin
Yanting Chen, Chuanming Xu, Chuanming Xu, Jiajia Hu, Mokan Deng, Qixiang Qiu, Shiqi Mo, Yanhua Du, Tianxin Yang   +8 more
doaj   +1 more source

Apelin and Vasopressin: The Yin and Yang of Water Balance

Frontiers in Endocrinology, 2021
Apelin, a (neuro)vasoactive peptide, plays a prominent role in controlling body fluid homeostasis and cardiovascular functions. Experimental data performed in rodents have shown that apelin has an aquaretic effect via its central and renal actions.
Pierre-Emmanuel Girault-Sotias, Romain Gerbier, Adrien Flahault, Nadia de Mota, Catherine Llorens-Cortes   +4 more
doaj   +1 more source

The Role of Apelin in Cardiovascular Diseases, Obesity and Cancer

Frontiers in Physiology, 2018
Apelin is an endogenous peptide identified as a ligand of the G protein-coupled receptor APJ. Apelin belongs to the family of adipokines, which are bioactive mediators released by adipose tissue.
Marta B. Wysocka, Katarzyna Pietraszek-Gremplewicz, Dorota Nowak   +2 more
doaj   +1 more source

Apelin alleviated neuroinflammation and promoted endogenous neural stem cell proliferation and differentiation after spinal cord injury in rats

Journal of Neuroinflammation, 2022
Background Spinal cord injury (SCI) causes devastating neurological damage, including secondary injuries dominated by neuroinflammation. The role of Apelin, an endogenous ligand that binds the G protein-coupled receptor angiotensin-like receptor 1, in ...
Qing Liu, Shuai Zhou, Xiao Wang, Chengxu Gu, Qixuan Guo, Xikai Li, Chunlei Zhang, Naili Zhang, Luping Zhang, Fei Huang   +9 more
doaj   +1 more source

Apelin System in Mammary Gland of Sheep Reared in Semi-Natural Pastures of the Central Apennines

Animals, 2018
Sheep are the most bred species in the Central Italy Apennine using the natural pastures as a trophic resource and grazing activity is fundamental to maintain the grassland biodiversity: this goal can be reached only ensuring an economical sustainability
Francesca Mercati, Margherita Maranesi, Cecilia Dall’Aglio, Linda Petrucci, Rolando Pasquariello, Federico Maria Tardella, Elena De Felice, Paola Scocco   +7 more
doaj   +1 more source

Chronic Effects of Apelin on Cardiovascular Regulation and Angiotensin II-Induced Hypertension

Pharmaceuticals, 2023
Apelin, by stimulation of APJ receptors, induces transient blood pressure (BP) reduction and positive inotropic effects. APJ receptors share high homology with the Ang II type 1 receptor; thus, apelin was proposed to play a protective role in ...
Qi Zhang, Yue Shen, Sayeman Islam Niloy, Stephen T. O'Rourke, Chengwen Sun   +4 more
doaj   +1 more source

Requirement of Apelin-Apelin Receptor System for Oxidative Stress-Linked Atherosclerosis [PDF]

The American Journal of Pathology, 2007
The recently identified endogenous peptide apelin and its specific apelin receptor (APJ) are currently being considered as potential regulators in vascular tissue. Previously, we reported apelin mediates phosphorylation of myosin light chain and elicits vasoconstriction in vascular smooth muscle.
Tatsuo, Hashimoto, Minoru, Kihara, Nozomi, Imai, Shin-Ichiro, Yoshida, Hiroaki, Shimoyamada, Hiroaki, Yasuzaki, Junji, Ishida, Yoshiyuki, Toya, Yoshihiro, Kiuchi, Nobuhito, Hirawa, Kouichi, Tamura, Takuya, Yazawa, Hitoshi, Kitamura, Akiyoshi, Fukamizu, Satoshi, Umemura   +14 more
openaire   +2 more sources