Apelin-13 enhances BMSCs osteogenic differentiation and bone regeneration under hypoxia via upregulation of Ibsp [PDF]
Stem Cell Research & TherapyBackground Apelin-13 plays a critical role in promoting angiogenesis and regulating cellular metabolism. However, the short half-life of Apelin-13 in vivo limits its further applications.
Junming Tao +8 more
doaj +2 more sources
Differential effects of apelin-13 on lipid peroxidation and DNA oxidation in doxorubicin-treated rats: A preliminary study [PDF]
Biomolecules & BiomedicineDoxorubicin-induced cardiotoxicity is closely associated with oxidative stress (OS), and apelin-13 has been proposed as a potential cardioprotective peptide. However, its effects on specific oxidative stress (OS) markers remain poorly understood.
Katarzyna Matusik +3 more
doaj +2 more sources
Piperine improves ischemic brain injury by promoting the regulation of the AMPK/PGC-1α pathway by Apelin 13 [PDF]
Frontiers in PharmacologyBackgroundIschemic stroke (IS) persists as the second foremost cause of mortality and the primary cause of long-term disability globally, a burden largely attributable to a paucity of effective therapeutic strategies.
Siyu Xi +12 more
doaj +2 more sources
Beneficial effects of Apelin-13 on metabolic diseases and exercise [PDF]
Frontiers in Endocrinology, 2023 Apelin, a novel endogenous ligand of the G-protein-coupled receptor APJ, is encoded by the APLN gene and can be hydrolyzed into multiple subtypes, with Apelin-13 being one of the most active subtypes of the Apelin family.
Ruiming Wen +4 more
doaj +2 more sources
Insights into the effects of apelin-13 on renal function and NHE3 activity following ischemia/reperfusion-induced acute kidney injury [PDF]
Frontiers in PhysiologyIntroductionAcute kidney injury (AKI) is a clinical syndrome characterized by rapid decline in renal function with varying severity. In this context, tubular function is impaired in ischemia-induced AKI. Although there are no effective therapies for AKI,
Guilherme Lopes-Gonçalves +4 more
doaj +2 more sources
Protective effect of apelin-13 in lens epithelial cells via inhibiting oxidative stress-induced apoptosis [PDF]
BMC OphthalmologyBackground It is widely accepted that glaucoma-induced oxidative stress expedites cataracts’ process. Therefore, we examined the effects of apelin-13 against oxidative stress-induced damage in human lens epithelial cells (HLECs) and investigated the ...
Xue Li +5 more
doaj +2 more sources
Efficacy evaluation and predictive value of IL-20 and Apelin-13 after cataract surgery by phacoemulsification combined with IOL implantation [PDF]
Frontiers in MedicineBackgroundPhacoemulsification combined with intraocular lens (IOL) implantation is the standard treatment for cataract. A proportion of patients still experience suboptimal visual outcomes or postoperative complications.
Shuang Liu +3 more
doaj +2 more sources
A reactive oxygen species-responsive hydrogel loaded with Apelin-13 promotes the repair of spinal cord injury by regulating macrophage M1/M2 polarization and neuroinflammation [PDF]
Journal of NanobiotechnologySpinal cord injury (SCI) is a chronic condition whereby persistent aberrant macrophage activation hinders the repair process. During acute trauma, dominant M1 macrophages produce high levels of reactive oxygen species (ROS), leading to increased ...
Zhiyue Li +5 more
doaj +2 more sources
Associations of FGF23 and Apelin-13 with osteoporosis and diabetic peripheral neuropathy in postmenopausal women with type 2 diabetes mellitus [PDF]
Frontiers in MedicineObjectiveTo investigate the correlations of various clinical indicators, fibroblast growth factor 23 (FGF23), and Apelin-13 with osteoporosis (OP) and diabetic peripheral neuropathy (DPN) in postmenopausal women with type 2 diabetes mellitus (T2DM), and ...
Yue Kong +5 more
doaj +2 more sources
Relationship Between Serum Apelin-13 and Apelin Receptor Levels and the Severity of Disease in Patients Diagnosed with Obstructive Sleep Apnea Syndrome [PDF]
DiagnosticsBackground and Objectives: Apelin-13 and its receptor (APJ) are increasingly recognized as key regulators of metabolic pathways that may contribute to the pathophysiology of obstructive sleep apnea (OSA) syndrome.
Demet Aygun +5 more
doaj +2 more sources