Results 21 to 30 of about 7,079 (169)
Frontiers in Neuroscience, 2020 Apelin is an endogenous neuropeptide, which has wide distribution in central nervous system and peripheral tissues. Pyroglutamyl apelin-13 [(pyr)apelin-13] is the major apelin isoform in human plasma.
Shuangyu Lv +6 more
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THE NEURONAL ANTIINFLAMMATORY EFFECTS OF APELIN-13
Turkish Journal of Health Science and Life, 2023 Objective: Apelin, a peptide with growth factor characteristic, is expressed in many cells and acts by binding to the APJ receptor. Apelin mRNA was detected in the central nervous system (CNS), macrophages and many peripheral tissues. According to recent studies, apelin protects neurons from hypoxia and glutamate-mediated excitotoxicity and can protect
Akif DOĞANTEKİN +2 more
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Apelin-13 regulates electrical activity in the globus pallidus and induces postural changes in rats
Neural Regeneration Research, 2021 The globus pallidus is the relay nucleus of the basal ganglia, and changes in its electrical activity can cause motor impairment. Apelin-13 is widely distributed in the central and peripheral nervous systems. It has been demonstrated that apelin-13 plays
Ying Wang, Yan Xue, Cui Liu, Lei Chen
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Stem Cells International, 2022 Although mesenchymal stem cell- (MSC-) based therapy has shown promising results for myocardial infarction (MI), low cell survival heavily limits its beneficial effects. Apelin plays an essential regulatory role in cell proliferation.
Guona Chen +11 more
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The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Serum apelin 13 levels in patients with pulmonary embolism [PDF]
European Respiratory Journal, 2014 Introduction and Aim A variety of adipokines has been reported in recent years that contribute to many different systemic processes. One of these novel adipokines, apelin, has become popular in the past decades.
Hadice, Selimoglu Şen +7 more
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Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice. [PDF]
PLoS ONE, 2018 Previous studies have shown that modified apelin analogues exhibited enzyme resistance in plasma and improved circulating half-life compared to apelin-13.
Finbarr P M O'Harte +3 more
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Frontiers in Pharmacology, 2020 Apelin is the endogenous ligand for APJ, a G-protein-coupled receptor. Apelin gene and protein are widely distributed in the central nervous system and peripheral tissues. The role of apelin in chronic inflammatory pain is still unclear.
Shuangyu Lv +5 more
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[Pyr1]Apelin-13(1–12) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide [Pyr1]Apelin-13 [PDF]
Frontiers in Neuroscience, 2017 Aims: Apelin is a predicted substrate for ACE2, a novel therapeutic target. Our aim was to demonstrate the endogenous presence of the putative ACE2 product [Pyr1]apelin-13(1-12) in human cardiovascular tissues and to confirm it retains significant biological activity for the apelin receptor in vitro and in vivo.
Yang, P +9 more
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Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress
Renal Failure, 2023 Contrast-induced acute kidney injury (CI-AKI) is a severe complication associated with significant morbidity and mortality, and effective therapeutic strategies are still lacking.
Qian Liu +9 more
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