Apelin-13 reverses bupivacaine-induced cardiotoxicity: an experimental study [PDF]
Brazilian Journal of AnesthesiologyIntroduction: Cardiac arrest or arrhythmia caused by bupivacaine may be refractory to treatment. Apelin has been reported to directly increase the frequency of spontaneous activation and the propagation of action potentials, ultimately promoting cardiac ...
Xixi Cai +4 more
doaj +5 more sources
Apelin-13: A promising biomarker for multiple sclerosis?
Annals of Indian Academy of Neurology, 2018 Objectives: Recent studies have shown that Apelin 13 may have a neuroprotective property. Therefore it can be used as a biomarker for multiple sclerosis.
Murat Alpua +3 more
doaj +5 more sources
Diagnostic and prognostic significance of apelin-13, APJ for sepsis in the emergency department: A prospective study [PDF]
HeliyonObjectives: This study aimed to assess the diagnostic, risk stratification, and prognostic capabilities of apelin-13 and APJ in comparison to procalcitonin (PCT) for septic patients presenting to the emergency department (ED).
Miaomiao Wang, Qian Gao, Shubin Guo
doaj +2 more sources
Apelin-13-Mediated Upregulation of METTL3 Ameliorates Alzheimer’s Disease via Inhibiting Neuroinflammation Through m6A-Dependent Regulation of lncRNA BDNF-AS [PDF]
BiomoleculesApelin-13, a neuropeptide, has been recognized for its neuroprotective properties. Our previous study found apelin-13 improves cognitive function in Alzheimer’s disease (AD) rats by inhibiting neuroinflammation through upregulation of BDNF/TrkB signaling
Li Han +7 more
doaj +2 more sources
Apelin-13 as a novel diagnostic laboratory biomarker in thromboembolic disorders: a review of literature with prospective insights [PDF]
International Journal of Emergency MedicineThromboembolic disorders, including deep vein thrombosis (DVT) and pulmonary embolism (PE), are major global health concerns, causing significant morbidity and mortality.
Mehdi Karimi +2 more
doaj +2 more sources
Intranasal Administration of Apelin-13 Ameliorates Cognitive Deficit in Streptozotocin-Induced Alzheimer’s Disease Model via Enhancement of Nrf2-HO1 Pathways [PDF]
Brain SciencesBackground: The discovery of novel diagnostic methods and therapies for Alzheimer’s disease (AD) faces significant challenges. Previous research has shed light on the neuroprotective properties of Apelin-13 in neurodegenerative disorders.
Hai Lu, Ming Chen, Cuiqing Zhu
doaj +2 more sources
Apelin-13 as a Potential Biomarker in Critical Illness. [PDF]
J Clin Med, 2023 Background: The adrenocortical system and copeptin as prognostic markers were intensively investigated in critical illness. The potential predictive power of apelin-13 as a biomarker is largely unknown. We aimed to investigate the prognostic role of apelin-13 in relation to free cortisol, aldosterone, CRH, and copeptin in critically ill patients ...
Gergics M +9 more
europepmc +3 more sources
Apelin-13 Protects Neurons by Attenuating Early-Stage Postspinal Cord Injury Apoptosis In Vitro
Brain Sciences, 2022 Apelin is a 77-amino-acid peptide that is an endogenous ligand for the G protein-coupled receptor APJ (Apelin receptor, APJ). Apelin-13, as the most bioactive affinity fragment of apelin, plays a role in energy metabolism, myocardial ischemia-reperfusion
Taotao Lin +7 more
doaj +1 more source
The protective effect of apelin-13 on cardiorenal toxicity induced by cyclophosphamide [PDF]
Canadian Journal of Physiology and Pharmacology, 2022 Cyclophosphamide is a chemotherapeutic drug that is widely used in the clinic and can cause multi-organ toxicity. Apelin-13 is an endogenous adipocytokine with antioxidant properties. Therefore, this study investigated the possibility of apelin-13 being a potential therapeutic agent on cardiac toxicity and nephrotoxicity caused by cyclophosphamide. In
Kutlay, Özden +2 more
openaire +3 more sources
Apelin-13 inhibits large-conductance Ca2+-activated K+ channels in cerebral artery smooth muscle cells via a PI3-kinase dependent mechanism. [PDF]
PLoS ONE, 2013 Apelin-13 causes vasoconstriction by acting directly on APJ receptors in vascular smooth muscle (VSM) cells; however, the ionic mechanisms underlying this action at the cellular level remain unclear.
Amit Modgil +3 more
doaj +1 more source