Results 1 to 10 of about 8,639 (118)
Apelin aggravates inflammatory response and hepatic steatosis in alcohol-associated liver disease via ERK signaling pathway [PDF]
Frontiers in PharmacologyBackgroundThough apelin is involved in cardiovascular, metabolic, and homeostasis disorders, its role in alcohol-associated liver disease (ALD) remains unclear.
Hongyan Bian +10 more
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PLoS ONE, 2022 Background The present systematic review and meta-analysis aimed to ascertain if the circulating levels of apelin, as an important regulator of the cardiovascular homeostasis, differ in patients with cardiovascular diseases (CVDs) and controls. Methods A
Hamed Akbari +8 more
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Myocardial injection of apelin-overexpressing bone marrow cells improves cardiac repair via upregulation of Sirt3 after myocardial infarction. [PDF]
PLoS ONE, 2013 Our previous study shows that treatment with apelin increases bone marrow cells (BMCs) recruitment and promotes cardiac repair after myocardial infarction (MI).
Lanfang Li +4 more
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Apelin and its Receptor: An Overview [PDF]
Journal of Clinical and Diagnostic Research, 2019 Apelin protein is an endogenous ligand of Apelin Receptor (APJ). APJ is a member of G-protein coupled receptor family. Both apelin and its receptor express extensively in the human body.
Rajeev Gandham +4 more
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Frontiers in Cardiovascular Medicine, 2022 BackgroundRecent studies suggest apelin has multiple protective effects in some cardiovascular diseases. However, there are few data concerning apelin levels in patients with obstructive hypertrophic cardiomyopathy (OHCM) or the relationship between ...
Chengzhi Yang +5 more
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Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization
Scientific Reports, 2021 The Apelin/APJ signalling pathway, involved in multiple physiological and pathological processes, has been attracting increasing interest recently. In our previous study, Apelin overexpression in colon26 tumor cells suppressed tumor growth by inducing ...
Liuying Hu +3 more
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Frontiers in Neuroscience, 2020 Apelin is an endogenous neuropeptide, which has wide distribution in central nervous system and peripheral tissues. Pyroglutamyl apelin-13 [(pyr)apelin-13] is the major apelin isoform in human plasma.
Shuangyu Lv +6 more
doaj +1 more source
Promoting effects of the adipokine, apelin, on diabetic nephropathy. [PDF]
PLoS ONE, 2013 Angiogenesis, increased glomerular permeability, and albuminuria are thought to contribute to the progression of diabetic nephropathy (DN). Apelin receptor (APLNR) and the endogenous ligand of APLNR, apelin, induce the sprouting of endothelial cells in ...
Bao-hai Zhang +4 more
doaj +1 more source
Apelin-13 Protects Neurons by Attenuating Early-Stage Postspinal Cord Injury Apoptosis In Vitro
Brain Sciences, 2022 Apelin is a 77-amino-acid peptide that is an endogenous ligand for the G protein-coupled receptor APJ (Apelin receptor, APJ). Apelin-13, as the most bioactive affinity fragment of apelin, plays a role in energy metabolism, myocardial ischemia-reperfusion
Taotao Lin +7 more
doaj +1 more source
Tumor endothelial cell-specific drug delivery system using apelin-conjugated liposomes. [PDF]
PLoS ONE, 2013 BACKGROUND: A drug delivery system specifically targeting endothelial cells (ECs) in tumors is required to prevent normal blood vessels from being damaged by angiogenesis inhibitors.
Hiroki Kawahara +5 more
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