Results 21 to 30 of about 12,228 (219)
Apelin as a potential treatment for chronic kidney disease [PDF]
, 2023 Chronic kidney disease (CKD) is a global health emergency. It affects ~10% of the global population, and cardiovascular disease is its commonest endpoint. Current standard of care treatment involves using blockers of the renin-angiotensin0aldosterone
Chapman, Fiona Anne
core +1 more source
Wiadomości Lekarskie, 2022 Apelin is a biologically active protein encoded by the APLN gene. It was first isolated in 1998 as a ligand for the APJ receptor. It exists in several isoforms differing in polypeptide chain length and biological activity. It is secreted by white adipose tissue, and its expression has been identified in many body tissues, including the cardiovascular ...
Kamil, Marczewski +4 more
openaire +3 more sources
Apelin and Pulmonary Hypertension [PDF]
Pulmonary Circulation, 2011 Pulmonary arterial hypertension (PAH) is a devastating disease characterized by pulmonary vasoconstriction, pulmonary arterial remodeling, abnormal angiogenesis and impaired right ventricular function. Despite progress in pharmacological therapy, there is still no cure for PAH.
Andersen, Charlotte Uggerhøj +4 more
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Cardiovascular effects of apelin in vivo in man [PDF]
, 2013 Background The apelin system is a novel peptidic pathway widely expressed in the heart and vasculature. In preclinical studies, apelin receptor agonism mediates nitric oxide-dependent vasodilatation, reduces ventricular preload and afterload and ...
Japp, Alan Gordon
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The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Apelin promotes blood and lymph vessel formation and the growth of melanoma lung metastasis
Scientific Reports, 2021 Apelin, a ligand of the APJ receptor, is overexpressed in several human cancers and plays an important role in tumor angiogenesis and growth in various experimental systems.
Judit Berta +15 more
doaj +1 more source
Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2and cell proliferationviaGαq-mediated mechanism [PDF]
, 2014 Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling.
Cai, X +9 more
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Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress
, 2023 Contrast-induced acute kidney injury (CI-AKI) is a severe complication associated with significant morbidity and mortality, and effective therapeutic strategies are still lacking.
Ying-Hao Deng (12587782) +9 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2021 The protective effects of mesenchymal stem cell (MSC)-based therapy for myocardial infarction (MI) are largely hampered as they age. Apelin is an endogenous ligand of its receptor APJ and plays an essential role in regulating multiple biological ...
Hao Zhang +18 more
doaj +1 more source
Effect of apelin on cardiac contractility in acute reno-vascular hypertension: The role of apelin receptor and kappa opioid receptor heterodimerization [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Apelin/APJ system plays an important role in the regulation of myocardial contractility (MC) and blood pressure. Opioid receptors (OPRs) are also important cardiovascular regulators and exert many of their effects through modulating the ...
Mahboobeh Yeganeh-Hajahmadi +4 more
doaj +1 more source