Results 11 to 20 of about 12,228 (219)
The role of apelin in cancer [PDF]
Frontiers in OncologyApelin is widely expressed in the body. Apelin is secreted as a propeptide and is proteolytically cleaved into six main isoforms. As an adipokine, apelin has a cardio- and neuroprotective role and is involved in angiogenesis in healthy tissue.
Yuki Agarwala, Rohini Sharma
doaj +4 more sources
On Methods for the Measurement of the Apelin Receptor Ligand Apelin
Scientific Reports, 2022 Apelin exists in many isoforms, both in the circulation and in specific tissues. Apelin peptides have a short half-life but preservation before measurement is scarcely studied.
Peter Janssens +6 more
doaj +4 more sources
Apelin and energy metabolism [PDF]
Frontiers in Physiology, 2015 A wide range of adipokines identified over the past years has allowed considering the white adipose tissue as a secretory organ closely integrated into overall physiological and metabolic control. Apelin, a ubiquitously expressed peptide was known to exert different physiological effects mainly on the cardiovascular system and the regulation of fluid ...
Bertrand, Chantal +2 more
openaire +5 more sources
Presence and expression of apelin and apelin receptor in bitch placenta
Theriogenology, 2020 Apelin is a potent inotropic agent causing endothelium-mediated vasodilation and is involved in vessel formation by interacting with a specific receptor. Its cardiovascular profile suggests a role in the regulation of gestational hemodynamic changes. The expression of apelin and its receptor has been reported in some portions of the reproductive tract ...
Troisi A. +6 more
core +5 more sources
Repression of apelin Furin cleavage sites provides antimetastatic strategy in colorectal cancer
EMBO Molecular MedicineThe adipokine apelin has been directly implicated in various physiological processes during embryogenesis and human cancers. Nevertheless, the importance of the conversion of its precursor proapelin to mature apelin in tumorigenesis remains unknown.
Béatrice Demoures +21 more
doaj +2 more sources
APELIN-12 AND APELIN-36 IN SPUTUM OF PATIENTS WITH BRONCHIAL ASTHMA [PDF]
Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2017 Relevance. In recent years, adipokines are considered as participants of pathogenesis in bronchial asthma (BA). The vast majority of studies on adipokines is based on the study of plasma (systemic) levels of adipokines.
V. N. Mineev, A. A. Kuzmina
doaj +2 more sources
Evaluation of serum apelin‐13 and apelin‐36 concentrations in preeclamptic pregnancies
Journal of Obstetrics and Gynaecology Research, 2019 AbstractAimRecent studies suggest that apelin can be a novel potential therapeutic mediator to improve the diagnosis, and treatment of preeclampsia. This study aimed to investigate the association of serum apelin‐13 and apelin‐36 with preeclampsia and to detect their relationship with preeclampsia‐associated perinatal morbidity.MethodsForty‐four women ...
Beril Gürlek +6 more
openaire +5 more sources
The impact of apelin-36 on isolated rat hearts as a member of apelin family
Bratislava Medical Journal, 2018 Apelin is an endogenous adipocytokine that plays an important role in the regulation of cardiovascular function. Apelin-36 is a member of apelin family. However cardiac reports related to apelin-36 are very rare. The purpose of this study is to investigate the impact of apelin-36 on hemodynamic variables of the isolated rat hearts.Twenty-eight rats ...
Kutlay, O.
openaire +5 more sources
Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin-ATF4 Axis. [PDF]
Adv Sci (Weinh)Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Chae SA +5 more
europepmc +2 more sources
Hepatology, EarlyView., 2022 Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid +20 more
wiley +1 more source