Journal of Interventional Cardiology, 2022 Background. Apelin-12 and estimated glomerular filtration rate (eGFR) are considered prognostic factors for ST-segment elevation myocardial infarction (STEMI).
Yue Liu +4 more
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Cells, 2022 Prostate cancer commonly affects the urinary tract of men and metastatic prostate cancer has a very low survival rate. Apelin belongs to the family of adipokines and is associated with cancer development and metastasis.
Tien-Huang Lin +13 more
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Low Dose of Apelin-36 Attenuates ER Stress-Associated Apoptosis in Rats with Ischemic Stroke
Frontiers in Neurology, 2017 Cerebral ischemia/reperfusion (I/R) injury-induced cellular apoptosis contributes to neuronal death in ischemic stroke, while endoplasmic reticulum stress (ERS) and subsequently triggered unfolded protein response (UPR) are the major mechanisms of ...
Jian Qiu +12 more
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Nauchno-prakticheskii zhurnal «Patogenez», 2021 Апелин - слово, появившееся в 1998 году. Так, по аббревиатуре рецептора APJ, авторы назвали, найденный ими лиганд этого рецептора. Существует в нескольких изоформах, от 13 до 77 аминокислотных остатков. Наиболее активна самая короткая форма: апелин-13. Образуется жировой и мышечной тканью - адипокин и миокин.
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Apelin and apelin receptor expression in renal cell carcinoma [PDF]
British Journal of Cancer, 2019 The APLNR (apelin receptor) has been shown to be an essential gene for cancer immunotherapy, with deficiency in APLNR leading to immunotherapy failure. The aim of this study is to investigate the expression of APLN (apelin) and APLNR in patients with renal cell carcinoma (RCC), and its association with clinicopathological parameters and survival.Three ...
Tolkach, Yuri +9 more
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Identification and functional characterization of the G-protein coupled receptor APJ and its ligand apelin in embryonic stem cells: a novel pathway regulating mammalian cardiomyogenesis [PDF]
, 2010 The commitment of mesodermal precursors to a cardiac fate is one of the first events in embryogenesis. It results from inductive interactions occurring during gastrulation in a temporally and spatially regulated manner. Embryonic Stem Cells (ESCs) are
D'Aniello, Cristina
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Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice. [PDF]
PLoS ONE, 2018 Previous studies have shown that modified apelin analogues exhibited enzyme resistance in plasma and improved circulating half-life compared to apelin-13.
Finbarr P M O'Harte +3 more
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Acylated apelin-13 amide analogues exhibit enzyme resistance and prolonged insulin releasing, glucose lowering and anorexic properties [PDF]
, 2017 The adipokine, apelin has many biological functions but its activity is curtailed by rapid plasma degradation. Fatty acid derived apelin analogues represent a new and exciting avenue for the treatment of obesity-diabetes.
Peter R Flatt +11 more
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Apelin ameliorates TNF-α-induced reduction of glycogen synthesis in the hepatocytes through G protein-coupled receptor APJ. [PDF]
PLoS ONE, 2013 Apelin, a novel adipokine, is the specific endogenous ligand of G protein-coupled receptor APJ. Consistent with its putative role as an adipokine, apelin has been linked to states of insulin resistance.
Jiaojiao Chu +8 more
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ASN Neuro, 2015 Apelin is a peptide originally isolated from bovine stomach tissue extracts and identified as an endogenous ligand of the APJ receptor; recent work showed that apelin ameliorates the ischemic injury in the heart and the brain.
Dongdong Chen +4 more
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