Results 51 to 60 of about 12,228 (219)

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

Advanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou, Fan Zhang, Jiangbo Wang, Huiyuan Wang, Zongqiang Wang, Qianqian Wang, Chuikai Meng, Jialu Sun, Han Wang, Weiye Li, Ziyi Zhao, Le Qi, Xiaosong Gu, Shusen Cui, Rangjuan Cao   +14 more
wiley   +1 more source

ELF5‐Mediated Enhancer–Promoter Interaction Regulates LALBA Expression in Ovine Mammary Gland

Advanced Science, EarlyView.
In the study, we systematically investigate the epigenetic mechanisms underlying lactation traits in sheep by integrating transcriptomic, chromatin accessibility, histone modification, and functional analyses. We identify a super‐enhancer at the LALBA locus and demonstrate that enhancer E4 functions as its core regulatory element.
Xinmiao Wu, Jiqing Wang, Zhiyun Hao, Mingna Li, Huimin Zhen, Yuan Liu, Guoyong Zhao, Chunyan Ren, Xuelan Zhou, Haixiong Hu, Mingjie Li, Nan Shi   +11 more
wiley   +1 more source

Fasting and Refeeding Mediated Phospholipid Remodeling Plays an Important Role in Improving Meat Quality of Aged Laying Hens

Animal Research and One Health, EarlyView.
ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang, Jun Zhang, Yadong Tian, Donghua Li, Yanhua Zhang, Lujie Zhang, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +8 more
wiley   +1 more source

Evaluation of angiogenic apelin/apelin receptor axis in normal prostate, high grade prostatic intraepithelial neoplasia and prostatic adenocarcinoma [PDF]

, 2022
Introduction and Objectives: Prostate cancer is one of the most commonly diagnosed cancers in American men. Apelin is an endogenous peptide identified as the ligand of the G protein-associated apelin receptor. Apelin and apelin receptor have many tissues
Ünal, B., Soylu, Hakan, Üstünel, İ., Caylan, A.E., Aksu, K., Avci, S.   +5 more
core   +3 more sources

Apelinerjik Sistem ve Miyokardiyal Kontraktilite

Uludağ Üniversitesi Tıp Fakültesi Dergisi, 2020
Apelinerjik sistem APJ (apelin reseptörü), apelin ve elabeladan oluşmaktadır. APJ, G protein kenetli bir reseptördür. Apelin ve elabela APJ’nin endojen ligandlarıdır.
Serdar Şahintürk, Naciye İşbil
doaj   +1 more source

The role of apelin in the retina of diabetic rats. [PDF]

PLoS ONE, 2013
PURPOSE: Apelin is a novel adipocytokine participating in diabetes, but its role in diabetic retinopathy (DR) is unknown. Our study aimed to investigate the effect of apelin on the proliferative potential in DR along with its antagonist inhibitory ...
Qiang Lu, Jing Feng, Yan-Rong Jiang
doaj   +1 more source

Beneficial long-term antidiabetic actions of N- and C-terminally modified analogues of apelin-13 in diet-induced obese diabetic mice [PDF]

, 2017
AimsTo investigate the chronic effects of twice‐daily administration of stable apelin analogues, apelin‐13 amide and pyroglutamyl (pGlu) apelin‐13 amide, on metabolic variables in glucose‐intolerant and insulin‐resistant diet‐induced obese mice fed a ...
Vadivel Parthsarathy, Finbarr P. M. O'Harte, O'Harte, Finbarr P. M., Parthsarathy, Vadivel, Hogg, Christopher, Flatt, Peter R., Christopher Hogg, O'Harte, Finbarr, Peter R. Flatt, Flatt, Peter, Hogg, C   +10 more
core   +1 more source

Gymnema sylvestre: Bioactive constituents, health benefits, and emerging applications in nutraceuticals and functional foods

JSFA reports, EarlyView.
Abstract Gymnema sylvestre (Retz.) R.Br. ex‐Schult., commonly known as “gurmar” or “sugar destroyer,” belongs to the Apocynaceae family and is traditionally used in Ayurveda for diabetes management. This review synthesizes ethnomedicinal evidence with contemporary pharmacological studies, to evaluate the therapeutic properties and mechanistic actions ...
Faiza Saeed, Muhammad Tauseef Sultan, Hassan Raza, Ahmad Mujtaba Noman, Nimra Haroon, Entessar Mohammad Al Jbawi   +5 more
wiley   +1 more source

2251

Journal of Clinical and Translational Science, 2017
OBJECTIVES/SPECIFIC AIMS: Women with pulmonary arterial hypertension (PAH) exhibit superior right ventricular (RV) function and survival compared with men, a phenomenon attributed to poorly understood cardioprotective effects of 17β-estradiol (E2).
Andrea Lee Frump, Margie Albrecht, Sandra Breuils-Bonnet, Bakhtiyor Yakubov, Mary Beth Brown, Steeve Provencher, Sebastien Bonnet, Tim Lahm   +7 more
doaj   +1 more source

Characterisation and validation of novel, stable apelin-13 analogues on neurodegeneration in AD. [PDF]

Introduction: Alzheimer’s disease is characterised by the cognitive decline, neuronal loss linked to oxidative stress, neuroinflammation, autophagy and endoplasmic reticulum (ER) stress. There are number of factors involved like lifestyle, genetics, age,
Sharma, P.
core   +1 more source