Results 41 to 50 of about 7,237 (173)

Expression of the apelinergic system and its influence on functional properties of tumor cells

Genetics & Applications, 2021
mall peptide Apelin and its cognate receptor APJ, are known to play a role in tumor angiogenesis and overall cancer progession. Certain authors suggest that the Apelin receptor is also a factor in cancer immunotherapy.
Zoran Knezevic, Jasmin Wellbrock, Frauke Fuchs, Gabi Vohwinkel, Antonia Matzat, Walter Fiedler   +5 more
doaj   +1 more source

Renal structural changes and apelin receptor expression in spontaneously hypertensive rats: implications for hypertension-induced kidney injury

Folia Morphologica
BACKGROUND: Arterial hypertension is a primary risk factor for kidney disease. Recent advances have implied a potential link between the apelin system and renal homeostasis.
Stancho Stanchev, Lyubomir Gaydarski, Iva N. Dimitrova, Georgi Kotov, Boycho Landzhov, Vidin Kirkov, Alexandar Iliev   +6 more
doaj   +1 more source

Temporal Expression of Apelin/Apelin Receptor in Ischemic Stroke and its Therapeutic Potential [PDF]

Frontiers in Molecular Neuroscience, 2017
Stroke is one of the leading causes of death and disability worldwide, and ischemic stroke accounts for approximately 87% of cases. Improving post-stroke recovery is a major challenge in stroke treatment. Accumulated evidence indicates that the apelinergic system, consisting of apelin and apelin receptor (APLNR), is temporally dysregulated in ischemic ...
Wu, Yili, Wang, Xin, Zhou, Xuan, Cheng, Baohua, Li, Gongying, Bai, Bo   +5 more
openaire   +2 more sources

The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target

Frontiers in Neurology, 2020
The orphan receptor APJ and its endogenous ligand apelin, which are expressed in the brain, are the major components of the apelin/APJ system. Growing evidence shows that the apelin/APJ system plays a vital role in the pathophysiology of cerebral ...
Yanjun Tian, Ruijiao Chen, Yunlu Jiang, Yunlu Jiang, Bo Bai, Tongju Yang, Haiqing Liu   +6 more
doaj   +1 more source

The beneficial roles of apelin-13/APJ system in cerebral ischemia: Pathogenesis and therapeutic strategies

Frontiers in Pharmacology, 2022
The incidence of cerebral ischemia has increased in the past decades, and the high fatality and disability rates seriously affect human health. Apelin is a bioactive peptide and the ligand of the G protein-coupled receptor APJ.
Jiabin Li, Zhang Chen, Jingyu Chen, Yue Yu   +3 more
doaj   +1 more source

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

The Apelin Receptor Is Coupled to Gi1 or Gi2 Protein and Is Differentially Desensitized by Apelin Fragments [PDF]

Journal of Biological Chemistry, 2006
The apelin receptor is a G protein-coupled receptor to which two ligand fragments, apelin-(65-77) and apelin-(42-77), can bind. To address the physiological significance of the existence of dual ligands for a single receptor, we first compared the ability of the apelin fragments to regulate intracellular effectors, to promote G protein coupling, and to
Masri, Bernard, Morin, Natacha, Pedebernade, Laure, Knibiehler, Bernard, Audigier, Yves   +4 more
openaire   +3 more sources

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Apelin-13 enhances arcuate POMC neuron activity via inhibiting M-current.

PLoS ONE, 2015
The hypothalamus is a key element of the neural circuits that control energy homeostasis. Specific neuronal populations within the hypothalamus are sensitive to a variety of homeostatic indicators such as circulating nutrient levels and hormones that ...
Dong Kun Lee, Jae Hoon Jeong, Seunghoon Oh, Young-Hwan Jo   +3 more
doaj   +1 more source

Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization

Scientific Reports, 2021
The Apelin/APJ signalling pathway, involved in multiple physiological and pathological processes, has been attracting increasing interest recently. In our previous study, Apelin overexpression in colon26 tumor cells suppressed tumor growth by inducing ...
Liuying Hu, Yumiko Hayashi, Hiroyasu Kidoya, Nobuyuki Takakura   +3 more
doaj   +1 more source