Results 61 to 70 of about 7,237 (173)

The Interactions Between Acetylcholine and T‐Cells and Their Role in the Immune System: A Scoping Review

Immunology, EarlyView.
Activated T‐cells instigate signalling events leading to the activation of transcription factors, which in turn, act on the nucleus to produce cytokines. We postulate that c‐fos is one of these transcription factors which upregulates the choline acetyltransferase gene responsible for synthesising acetylcholine (ACh).
Jarita Lay, Nicholas Manolios
wiley   +1 more source

Salivary Apelin Levels and Periodontal Findings in Individuals With/Without Type 1 Diabetes and Varying Degrees of Gingival Inflammation

Oral Diseases, EarlyView.
ABSTRACT Objective To evaluate salivary apelin levels in individuals with and without type 1 diabetes presenting an intact periodontium and varying degrees of plaque‐induced gingival inflammation. Methods Saliva samples were collected; and whole‐mouth clinical periodontal measurements were recorded in type 1 diabetes and systemically healthy ...
Demet Efe Yavaşoğlu, Andressa V. B. Nogueira, Mehmet Demirbaş, Timur Köse, Sebahat Kaya, James Deschner, Nurcan Buduneli   +6 more
wiley   +1 more source

Controlled ovarian hyperstimulation increases the expression of apelin and apelin receptor in uterus

Akdeniz Medical Journal, 2022
Objective; In this study, we investigated whether superovulation, which is frequently used in the clinic as controlled ovarian hyperstimulation, affect the expression of Apelin (APLN) and Apelin Receptor (APJ) in the uterus. Methods: Twelve female Balb-C mice 6-8 weeks old were used in this study.
Sema AVCI, Çiler ÇELİK-ÖZENCİ
openaire   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Sodium–glucose cotransporter 2 inhibitors for hypertension in cardiovascular–kidney–metabolic syndrome

Experimental Physiology, EarlyView.
Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu, Xingyu Qiu, Nan Xu, Gensheng Zhang, Enyin Lai, Liang Zhao   +5 more
wiley   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, Volume 14, Issue 8, Page 2401-2418, November 2026.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

BS16 A novel fluorescent apelin ligand tracks apelin receptor internalisation [PDF]

Basic Science, 2019
Introduction Fluorescent ligands are a promising tool in the study of GPCR pharmacology as they are safe and more cost effective than conventional probes such as radioligands. In this study, we investigated the use of a novel fluorescent ligand, apelin-488, to successfully show qualitative and quantitative apelin receptor internalisation, which may ...
Elisabeth O’Flaherty, Tom Williams, Duuamene Nyimanu, Robyn Macrae, Heather Currinn, Jason Brown, Alastair Brown, Gregory Strachan, Janet Maguire, Anthony Davenport   +9 more
openaire   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Multi‐omics integration and machine learning identify an ACKR1+ endothelial cell‐based lactate‐immune signature associated with carotid plaque vulnerability and progression

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
ACKR1+ endothelial cells mark intraplaque neovessels with hyperactive glycolysis and lactate metabolism. Lactate, HIF‐1α and CXCL12 link this state to CXCR4+ CD8+ T‐cell recruitment in situ. SLC16A3 and SLC16A4 serve as quantitative readouts of this lactate–immune state.
Ji Zhang, Qijian Zhao, Yufei Wu, Keqiang Shu, Junye Chen, Kang Li, Yuyao Feng, Xu Zhang, Wenjian Liu, Zhichao Lai, Bao Liu   +10 more
wiley   +1 more source

The Apelin/APJ System in Psychosis and Neuropathy

Frontiers in Pharmacology, 2020
Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the G-protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely expressed in the central nervous system and peripheral tissues of humans and animals ...
Shuang-Yu Lv, Wei-Dong Chen, Wei-Dong Chen, Yan-Dong Wang   +3 more
doaj   +1 more source