Results 81 to 90 of about 7,237 (173)

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

Cell Proliferation, Volume 59, Issue 10, October 2026.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu, Yanan Guo, Kangjian Xiang, Shuyi Wang, Dongchang Xiao, Mengqing Xiang   +5 more
wiley   +1 more source

Apelin modulates inflammation and leukocyte recruitment in experimental autoimmune encephalomyelitis

Nature Communications
Demyelination due to autoreactive T cells and inflammation in the central nervous system are principal features of multiple sclerosis (MS), a chronic and highly disabling human disease affecting brain and spinal cord.
Hongryeol Park, Jian Song, Hyun-Woo Jeong, Max L. B. Grönloh, Bong Ihn Koh, Esther Bovay, Kee-Pyo Kim, Luisa Klotz, Patricia A. Thistlethwaite, Jaap D. van Buul, Lydia Sorokin, Ralf H. Adams   +11 more
doaj   +1 more source

Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C

Mediators of Inflammation, 2011
Objective. Highlighting the apelin system would present a new therapeutic target for liver disease. Apelin; endogenous ligand for the orphan receptor APJ, was recently suggested to be associated with fibrosis progression and cirrhosis in addition to ...
Hala O. El-Mesallamy, Nadia M. Hamdy, Hanan H. Rizk, Abdel-Rahman El-Zayadi   +3 more
doaj   +1 more source

Is serum apelin related to portal hemodynamics in patients with liver cirrhosis?

The Egyptian Journal of Internal Medicine, 2018
Background Apelin is the endogenous ligand of the angiotensin-like receptor. The expression of apelin–APJ (apelin receptor) signaling is associated with the development of portal hypertension (PH) and contributes toward the formation of Porto systemic ...
Ashraf G Dala, Osama M Ebied, Gamal Y Abo-Raia   +2 more
doaj   +1 more source

Apelin-13/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and oxidative stress in a AMPK-dependent manner after subarachnoid hemorrhage in rats

Journal of Neuroinflammation, 2019
Background Neuroinflammation and oxidative stress play important roles in early brain injury following subarachnoid hemorrhage (SAH). This study is the first to show that activation of apelin receptor (APJ) by apelin-13 could reduce endoplasmic reticulum
Weilin Xu, Tao Li, Liansheng Gao, Jingwei Zheng, Jun Yan, Jianmin Zhang, Anwen Shao   +6 more
doaj   +1 more source

Apelin Protects Primary Rat Retinal Pericytes from Chemical Hypoxia-Induced Apoptosis

Journal of Ophthalmology, 2015
Pericytes are a population of cells that participate in normal vessel architecture and regulate permeability. Apelin, as the endogenous ligand of G protein-coupled receptor APJ, participates in a number of physiological and pathological processes.
Li Chen, Yong Tao, Jing Feng, Yan Rong Jiang   +3 more
doaj   +1 more source

Repression of apelin Furin cleavage sites provides antimetastatic strategy in colorectal cancer

EMBO Molecular Medicine
The adipokine apelin has been directly implicated in various physiological processes during embryogenesis and human cancers. Nevertheless, the importance of the conversion of its precursor proapelin to mature apelin in tumorigenesis remains unknown.
Béatrice Demoures, Fabienne Soulet, Jean Descarpentrie, Isabel Galeano-Otero, José Sanchez Collado, Maria Casado, Tarik Smani, Alvaro González, Isabel Alves, Fabrice Lalloué, Bernard Masri, Estelle Rascol, Jean-William Dupuy, Cyril Dourthe, Frédéric Saltel, Anne-Aurélie Raymond, Iker Badiola, Serge Evrard, Bruno Villoutreix, Simon Pernot, Géraldine Siegfried, Abdel-Majid Khatib   +21 more
doaj   +1 more source

Post-translational modifications of the apelin receptor regulate its functional expression. [PDF]

AIMS Neurosci, 2023
Kinjo T, Ebisawa S, Nokubo T, Hashimoto M, Yamada T, Oshio M, Nakamura R, Uno K, Kuramoto N.   +8 more
europepmc   +1 more source

The apelin‑apelin receptor signaling pathway in fibroblasts is involved in tumor growth via p53 expression of cancer cells. [PDF]

Int J Oncol, 2023
Saiki H, Hayashi Y, Yoshii S, Kimura E, Nakagawa K, Kato M, Uema R, Inoue T, Sakatani A, Yoshihara T, Tsujii Y, Shinzaki S, Iijima H, Takehara T.   +13 more
europepmc   +1 more source

Cancer apelin receptor suppresses vascular mimicry in malignant melanoma. [PDF]

Pathol Oncol Res, 2023
Inukai K, Kise K, Hayashi Y, Jia W, Muramatsu F, Okamoto N, Konishi H, Akuta K, Kidoya H, Takakura N.   +9 more
europepmc   +1 more source