Results 41 to 50 of about 23,200 (255)

Apj+ Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target.

Cell Reports, 2022
Identification of cellular surface markers that distinguish tumorous from normal vasculature is important for the development of tumor vessel-targeted therapy.
Huan Zhao, Xueying Tian, Lingjuan He, Yan Li, Wen-Juan Pu, Qiaozhen Liu, Juan Tang, Jiaying Wu, Xin Cheng, Yang Liu, Qingtong Zhou, Zhen Tan, F. Bai, Fei Xu, N. Smart, Bin Zhou   +15 more
semanticscholar   +1 more source

The apelin-APJ system in the evolution of heart failure [PDF]

Medicine and Pharmacy Reports, 2015
Heart failure is a chronic, progressive disease in which the overexpression of biologically active molecules and neurohomonal activation are the key factors of the evolution and natural history. The apelin-APJ system is a newly discovered molecular pathway and the RAAS counterbalance is its principal effect. The apelin is a potent inotrope, vasodilator
Cerasela Mihaela Goidescu, Luminița Animarie Vida-Simiti   +1 more
openaire   +2 more sources

Cardiovascular response to small-molecule APJ activation [PDF]

JCI Insight, 2020
Heart failure (HF) remains a grievous illness with poor prognosis even with optimal care. The apelin receptor (APJ) counteracts the pressor effect of angiotensin II, attenuates ischemic injury, and has the potential to be a novel target to treat HF. Intravenous administration of apelin improves cardiac function acutely in patients with HF. However, its
Brandon Ason, Yinhong Chen, Qi Guo, Kimberly M. Hoagland, Ray W. Chui, Mark Fielden, Weston Sutherland, Rhonda Chen, Ying Zhang, Shirley Mihardja, Xiaochuan Ma, Xun Li, Yaping Sun, Dongming Liu, Khanh Nguyen, Jinghong Wang, Ning Li, Sridharan Rajamani, Yusheng Qu, BaoXi Gao, Andrea Boden, Vishnu Chintalgattu, Jim R. Turk, Joyce Chan, Liaoyuan A. Hu, Paul Dransfield, Jonathan Houze, Jingman Wong, Ji Ma, Vatee Pattaropong, Murielle M. Véniant, Hugo M. Vargas, Gayathri Swaminath, Aarif Y. Khakoo   +33 more
openaire   +2 more sources

Coronal heating distribution due to low-frequency, wave-driven turbulence [PDF]

, 2002
The heating of the lower solar corona is examined using numerical simulations and theoretical models of magnetohydrodynamic turbulence in open magnetic regions.
Dmitruk, Pablo, Mullan, D. J., Matthaeus, William H., G. P. Zank, Oughton, Sean, S. Oughton, P. Dmitruk, L. J. Milano, W. H. Matthaeus, Zank, Gary P., Milano, L. J., D. J. Mullan   +11 more
core   +1 more source

Expression and Coreceptor Function of APJ for Primate Immunodeficiency Viruses [PDF]

, 2000
APJ is a seven transmembrane domain G-protein-coupled receptor that functions as a coreceptor for some primate immunodeficiency virus strains. The in vivo significance of APJ coreceptor function remains to be elucidated, however, due to the lack of an ...
Tsang, Monica, Coughlan, Christine M., Price, Ken, Lee, Benhur, Baribaud, Frédéric, Sharron, Matthew, McManus, Carrie M., Doms, Robert W., Puffer, Bridget A., Horuk, Richard, David, Jim   +10 more
core   +1 more source

Apelin/APJ alleviates diabetic nephropathy by improving glomerular endothelial cells dysfunction via SIRT3‑KLF15

Molecular Medicine Reports
Glomerular basement membrane (GBM) thickening, the earliest morphological change of diabetic nephropathy (DN), is related to glomerular endothelial cells (GECs) dysfunction which increase extracellular matrix (ECM) synthesizing.
Mingcong Huang, Jing Chang, Yu Liu, Jiming Yin, Xiangjun Zeng   +4 more
semanticscholar   +1 more source

Adipokine Apelin/APJ Pathway Promotes Peritoneal Dissemination of Ovarian Cancer Cells by Regulating Lipid Metabolism

Molecular Cancer Research, 2021
Adipose tissue, which can provide adipokines and nutrients to tumors, plays a key role in promoting ovarian cancer metastatic lesions in peritoneal cavity.
S. Dogra, D. Neelakantan, Maulin M. Patel, Beth A. Griesel, A. Olson, S. Woo   +5 more
semanticscholar   +1 more source

Effect of apelin on cardiac contractility in acute reno-vascular hypertension: The role of apelin receptor and kappa opioid receptor heterodimerization [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Apelin/APJ system plays an important role in the regulation of myocardial contractility (MC) and blood pressure. Opioid receptors (OPRs) are also important cardiovascular regulators and exert many of their effects through modulating the ...
Mahboobeh Yeganeh-Hajahmadi, Hamid Najafipour, Farzaneh Rostamzadeh, saeed Esmaeili Mahani, Siavash Joukar   +4 more
doaj   +1 more source

Partially-erupting prominences: a comparison between observations and model-predicted observables [PDF]

, 2009
<p><b>Aims:</b> We investigate several partially-erupting prominences to study their relationship with other CME-associated phenomena and compare these observations with observables predicted by a model of partially-expelled-flux-ropes (
D. Tripathi, Liu, R., Mason, H.E., Fletcher, L., L. Fletcher, S. E. Gibson, H. E. Mason, Gibson, S.E., R. Liu, H. Gilbert, Gilbert, H., Tripathi, D., Qiu, J., J. Qiu   +13 more
core   +1 more source

Apelinerjik Sistem ve Miyokardiyal Kontraktilite

Uludağ Üniversitesi Tıp Fakültesi Dergisi, 2020
Apelinerjik sistem APJ (apelin reseptörü), apelin ve elabeladan oluşmaktadır. APJ, G protein kenetli bir reseptördür. Apelin ve elabela APJ’nin endojen ligandlarıdır.
Serdar Şahintürk, Naciye İşbil
doaj   +1 more source