Results 61 to 70 of about 23,200 (255)

The Elabela-APJ axis attenuates sepsis-induced myocardial dysfunction by reducing pyroptosis by balancing the formation and degradation of autophagosomes.

Free Radical Biology & Medicine
BACKGROUND Sepsis is a life-threatening severe inflammatory reaction caused by the host's dysregulated response to infection. Sepsis-induced myocardial dysfunction (SIMD) has been confirmed to occur in 50% of patients with septic shock.
Shuai Liu, Fu Liu, Jue-Yue Yan, Xing Fang, Zhi-Peng Xu, Hong-Liu Cai, Yingjun Yang, Yong-Wei Yu   +7 more
semanticscholar   +1 more source

Intelligent Automation Improved Efficiency in Pharmacovigilance Safety Signal Assessment

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacovigilance is the science involving the detection, assessment, understanding, and prevention of adverse events associated with drugs, biologics, or medical devices. In pharmacovigilance, information that suggests a new potential causal relationship between an intervention and an adverse event is called a safety signal. Following their detection,
Jeffrey Warner, Luis Henrique De Souza Teodoro, Anaclara Prada Jardim, Claudia Albera   +3 more
wiley   +1 more source

The first scientific experiment using Global e-VLBI observations: a multiwavelength campaign on the gamma-ray Narrow-Line Seyfert 1 PMN J0948+0022 [PDF]

, 2010
The detection of gamma-ray emission by Fermi-LAT from the radio loud Narrow Line Seyfert 1 PMN J0948+0022 (Abdo et al. 2009, ApJ 699, 976) triggered a multi-wavelength campaign between March and July 2009. Given its high compactness (Doi et al.
Paragi, Zsolt, Tzioumis, A.K., Foschini, L, Blanchard, J, Hong, X, Giroletti, Marcello, Kadler, M, Bignall, Hayley, Gabanyi, K, Doi, A, Nagai, H, Kino, M, Colomer, F, Sekido, M, Szomoru, A, Langevelde, H.J. van, Phillips, C   +16 more
core  

APJ expression in cultured CVSMCs.

, 2013
(A) APJ mRNA expression in CVSMCs. Total RNA from CVSMCs was subjected to RT-PCR. The PCR products were visualized in a 1.5% agarose gel stained with ethidium bromide.
Rong-Rong Cui (326255), Peng-Fei Shan (354604), Ling-Qing Yuan (326265), Yi Jiang (40197), Ying Lu (66401), Er-Yuan Liao (326266)   +5 more
core   +1 more source

Xiaoyaosan Improves Depressive-Like Behaviors in Mice through Regulating Apelin-APJ System in Hypothalamus

Molecules, 2018
Background: The apelin-APJ system has been considered to play a crucial role in HPA axis function, and how the traditional Chinese compound prescription Xiaoyaosan regulates the apelin-APJ system as a supplement to treat depressive disorders.
Zhiyi Yan, Haiyan Jiao, Xiufang Ding, Qingyu Ma, Xiaojuan Li, Qiuxia Pan, Tingye Wang, Yajing Hou, Youming Jiang, Yueyun Liu, Jiaxu Chen   +10 more
doaj   +1 more source

The implementation of an innovative just‐in‐time educational huddle for faculty development of academic hospitalists

Journal of Hospital Medicine, EarlyView.
Abstract Academic hospitalists supervising residents on inpatient wards face the dual challenge of managing changing patient complexity and learner needs. Resident experience is highly dependent on supervising faculty; however, traditional faculty development often fails to respond to real‐time challenges of clinical teaching.
Donna Coetzee, Suman Pal, Elizabeth Davis, Andrew P. J. Olson, Melissa Plesac   +4 more
wiley   +1 more source

Internalization of apelin via cell surface APJ.

, 2013
(A) Western blot analysis of mouse APJ-GFP fusion protein on NIH-3T3 cells. Anti-GFP antibody was used to detect APJ-GFP. Flotillin is the positive control for membrane proteins on NIH-3T3 cells. β-actin was used as the internal control.
Hiroki Kawahara (422065), Taku Wakabayashi (387169), Hisamichi Naito (387167), Hiroyasu Kidoya (387166), Kazuhiro Takara (422066), Nobuyuki Takakura (116795)   +5 more
core   +1 more source

Targeting APJ drives BNIP3-PINK1-PARKIN induced mitophagy and improves systemic inflammatory bone loss

Journal of Advanced Research
Introduction: Inflammatory diseases, such as diabetes mellitus, rheumatoid arthritis, and inflammatory bowel disease, lead to systemic immune microenvironment disturbances, contributing to bone loss, yet the mechanisms by which specific receptors ...
Wentao Wang, Qing Wang, Wenming Li, Hao Xu, Xiaolong Liang, Wei Wang, Ning Li, Huilin Yang, Yaozeng Xu, Jiaxiang Bai, Shuli Yang, Dechun Geng   +11 more
doaj   +1 more source

Maternal obesity reduces apelin level in cord blood without altering the placental apelin/elabela-APJ system.

Placenta, 2022
The APJ receptor and its two endogenous ligands, apelin and elabela, exert key roles in fetoplacental development. In adult, this system is altered by obesity but no data are available during pregnancy.
S. Hanssens, Lucie Marousez, Océane Pécheux, Capucine Besengez, L. Storme, P. Deruelle, D. Eberlé, J. Lesage   +7 more
semanticscholar   +1 more source

Association of Nasal Anatomy, Airflow, and Surgery With Olfactory Outcomes: A State‐of‐the‐Art Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Olfactory function is influenced by nasal airflow dynamics and anatomical variations within the nasal cavity. This narrative review evaluates how nasal anatomy and airflow relate to olfactory outcomes, with a particular focus on olfactory changes following functional nasal surgery. Data Sources PubMed.
Joshua Ferreira, Alfonso Luca Pendolino, Riccardo Pappalardo, Peter J. Andrews   +3 more
wiley   +1 more source