Results 51 to 60 of about 23,200 (255)

The G protein‐coupled receptor ligand apelin‐13 ameliorates skeletal muscle atrophy induced by chronic kidney disease

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Targeting of the apelin–apelin receptor (Apj) system may serve as a useful therapeutic intervention for the management of chronic kidney disease (CKD)‐induced skeletal muscle atrophy.
Yuki Enoki, Tomoya Nagai, Yuna Hamamura, Sumika Osa, Hideaki Nakamura, Kazuaki Taguchi, Hiroshi Watanabe, Toru Maruyama, Kazuaki Matsumoto   +8 more
doaj   +1 more source

Apelin/APJ: Another Player in the Cancer Biology Network

International Journal of Molecular Sciences
The apelinergic system exerts multiple biological activities in human pathologies, including cancer. Overactivation of apelin/APJ, which has been detected in many malignant tumors, and the strong correlation with progression-free and overall survival ...
L. Naldi, Alessandro Peri, B. Fibbi
semanticscholar   +1 more source

The beneficial roles of apelin-13/APJ system in cerebral ischemia: Pathogenesis and therapeutic strategies

Frontiers in Pharmacology, 2022
The incidence of cerebral ischemia has increased in the past decades, and the high fatality and disability rates seriously affect human health. Apelin is a bioactive peptide and the ligand of the G protein-coupled receptor APJ.
Jiabin Li, Zhang-qiang Chen, Jingyu Chen, Yue Yu   +3 more
semanticscholar   +1 more source

Nonlinear fast magnetoacoustic wave propagation in the neighbourhood of a 2D magnetic X-point : oscillatory reconnection [PDF]

, 2008
Context. This paper extends the models of Craig & McClymont (1991, ApJ, 371, L41) and McLaughlin & Hood (2004, A&A, 420, 1129) to include finite β and nonlinear effects. Aims. We investigate the nature of nonlinear fast magnetoacoustic waves about a 2D
Hood, Alan William, Brady, Christopher S., Moortel, I. de, Hood, Alan W., J. A. McLaughlin, De Moortel, I., McLaughlin, James, A. W. Hood, de Moortel, Ineke, McLaughlin, J. A. (James A.), I. De Moortel, Hood, A. W., McLaughlin, J. A., C. S. Brady, McLaughlin, JA, Brady, C   +15 more
core   +1 more source

Single‐cell and spatial transcriptomics reveal apelin/APJ pathway's role in microvessel formation and tumour progression in hepatocellular carcinoma

Journal of Cellular and Molecular Medicine
The apelin receptor (APJ) is a key player in tumour angiogenesis, but its role in hepatocellular carcinoma (HCC) remains unclear. This study aims to elucidate the function of the apelin/APJ pathway in HCC using a multi‐omics approach and identify ...
Yong-Fu Zhu, Peng-Cheng Zhang, Xing-Xing Huo, Yi Ling, Xiang Lv, Sheng-You Lin, Hang Song   +6 more
semanticscholar   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

The regulatory role of the apelin/APJ axis in scarring: Identification of upstream and downstream mechanisms.

Biochimica et Biophysica Acta - Molecular Basis of Disease
Scarring, a prevalent issue in clinical settings, is characterized by the excessive generation of extracellular matrix within the skin tissue. Among the numerous regulatory factors implicated in fibrosis across various organs, the apelin/APJ axis has ...
Nian Shi, Yi Wang, Zhen-Yu Xia, Jing-Juan Zhang, Shanshan Jia, Y. Jiao, Chao Wang, Xiao-Yang Wang, Jie Zhao, Ji-Xun Zhang, Du-Yin Jiang   +10 more
semanticscholar   +1 more source

Apelin/Elabela-APJ: a novel therapeutic target in the cardiovascular system

Annals of Translational Medicine, 2020
Apelin and Elabela (ELA) are endogenous ligands of angiotensin domain type 1 receptor-associated proteins (APJ). Apelin/ELA-APJ signal is widely distributed in the cardiovascular system of fetuse and adult.
Wei Liu, Jia-long Yan, Wei-Nan Pan, Mengjie Tang   +3 more
semanticscholar   +1 more source

In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure

Circulation: Heart Failure, 2021
Supplemental Digital Content is available in the text. Background: New heart failure therapies that safely augment cardiac contractility and output are needed.
Peter S. Gargalovic, P. Wong, J. Onorato, Heather J. Finlay, Tao Wang, Mu-Jing Yan, Earl J. Crain, S. St-Onge, Madeleine Héroux, M. Bouvier, Carrie Xu, Xue-Qing Chen, Claudia Generaux, Michael Lawrence, R. Wexler, D. Gordon   +15 more
semanticscholar   +1 more source

Fibrilpaint: A Class of Amyloid‐Targeting Peptides

Chemistry – A European Journal, EarlyView.
FibrilPaints are modular peptides engineered to recognize amyloid fibrils. By systematically varying charge, sequence, and termini, their binding behavior can be tuned while retaining recognition. Successful binding ″paints″ fibrils for visualization and opens routes toward targeted degradation and diagnostic applications.
Júlia Aragonès Pedrola, Françoise A. Dekker, Katrin Guttmann, Litske M. van Leeuwen, Shalini Singh, Guy Mayer, Tommaso Garfagnini, Assaf Friedler, Stefan G. D. Rüdiger   +8 more
wiley   +1 more source