Results 171 to 180 of about 12,228 (219)

An orally active apelin receptor agonist improves Alzheimer’s disease pathology and cognitive functions by restoring microglial metabolism

open access: yes
Ma OK   +11 more
europepmc   +1 more source

Apelin, diabetes, and obesity

open access: yesEndocrine, 2011
Apelin is a peptide known as the ligand of the G-protein-coupled receptor APJ. Several active apelin forms exist such as apelin-36, apelin-17, apelin-13, and the pyroglutamated form of apelin-13. Apelin and APJ are expressed in the central nervous system, particularly in the hypothalamus and in many peripheral tissues.
Claude Knauf   +2 more
exaly   +4 more sources

Structural Basis for Apelin Control of the Human Apelin Receptor [PDF]

open access: yesStructure, 2017
Apelin receptor (APJR) is a key regulator of human cardiovascular function and is activated by two different endogenous peptide ligands, apelin and Elabela, each with different isoforms diversified by length and amino acid sequence. Here we report the 2.6-Å resolution crystal structure of human APJR in complex with a designed 17-amino-acid apelin ...
Suwen Zhao, Qingtong Zhou, Liaoyuan A Hu
exaly   +3 more sources

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