Results 61 to 70 of about 260,718 (281)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Novel active pharmaceutical ingredients from India: The actors-Part-I

MGM Journal of Medical Sciences, 2021
Sixteen novel active pharmaceutical ingredients, namely Urea stibamine, Methaqualone, Enfenamic acid, Hamycin, Centimizole, Centbutindole, Ormiloxifene, Centpropazine, Centbucridine, Alpha-beta-arteether, Bulaquine, Chandonium Iodide, Sintamil ...
Prasanta Kumar Ghosh
doaj   +1 more source

Semantic annotation of Web APIs with SWEET [PDF]

, 2010
Recently technology developments in the area of services on the Web are marked by the proliferation of Web applications and APIs. The development and evolution of applications based on Web APIs is, however, hampered by the lack of automation that can be ...
Domingue, John, Maleshkova, Maria, Pedrinaci, Carlos   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Varroasis y mécanismos de defensa de la abeja melífera (Apis mellifera)

Revista de Producción Animal, 2019
Antecedentes: La abeja melífera se encuentra amenazada por varios factores que provocan lo que hoy en día se conoce a nivel mundial como el Síndrome de Colapso de las colmenas, entre los cuales destaca la presencia del ácaro Varroa destructor.
Diego Armando Masaquiza Moposita , Lino Miguel Curbelo , Byron Leoncio Díaz Monroy , Amílcar Arenal Cruz   +3 more
doaj  

Development of an electrochemical biosensor based on rGO/Ag₂S-Au nanocomposites and L-CHA dual signal amplification for miR-155 detection

Biomedical Analysis
MicroRNA-155 (miR-155) is a critical biomarker implicated in various pathological processes, including cancer progression, immune response, and cardiovascular diseases.
Shan Ou, Rui Li, Yonghua Yuan, Yueyuan Li, Lijuan Bai, Yuhan Chen   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Long-Term Temporal Trends of Nosema spp. Infection Prevalence in Northeast Germany: Continuous Spread of Nosema ceranae, an Emerging Pathogen of Honey Bees (Apis mellifera), but No General Replacement of Nosema apis

Frontiers in Cellular and Infection Microbiology, 2017
The Western honey bee (Apis mellifera) is widely used as commercial pollinator in worldwide agriculture and, therefore, plays an important role in global food security.
Sebastian Gisder, Vivian Schüler, Lennart L. Horchler, Detlef Groth, Elke Genersch, Elke Genersch   +5 more
doaj   +1 more source