Results 61 to 70 of about 263,028 (274)

Polyglot Semantic Parsing in APIs

, 2018
Traditional approaches to semantic parsing (SP) work by training individual models for each available parallel dataset of text-meaning pairs. In this paper, we explore the idea of polyglot semantic translation, or learning semantic parsing models that ...
Berant, Jonathan, Kuhn, Jonas, Richardson, Kyle   +2 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Varroasis y mécanismos de defensa de la abeja melífera (Apis mellifera)

Revista de Producción Animal, 2019
Antecedentes: La abeja melífera se encuentra amenazada por varios factores que provocan lo que hoy en día se conoce a nivel mundial como el Síndrome de Colapso de las colmenas, entre los cuales destaca la presencia del ácaro Varroa destructor.
Diego Armando Masaquiza Moposita , Lino Miguel Curbelo , Byron Leoncio Díaz Monroy , Amílcar Arenal Cruz   +3 more
doaj  

Development of an electrochemical biosensor based on rGO/Ag₂S-Au nanocomposites and L-CHA dual signal amplification for miR-155 detection

Biomedical Analysis
MicroRNA-155 (miR-155) is a critical biomarker implicated in various pathological processes, including cancer progression, immune response, and cardiovascular diseases.
Shan Ou, Rui Li, Yonghua Yuan, Yueyuan Li, Lijuan Bai, Yuhan Chen   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Long-Term Temporal Trends of Nosema spp. Infection Prevalence in Northeast Germany: Continuous Spread of Nosema ceranae, an Emerging Pathogen of Honey Bees (Apis mellifera), but No General Replacement of Nosema apis

Frontiers in Cellular and Infection Microbiology, 2017
The Western honey bee (Apis mellifera) is widely used as commercial pollinator in worldwide agriculture and, therefore, plays an important role in global food security.
Sebastian Gisder, Vivian Schüler, Lennart L. Horchler, Detlef Groth, Elke Genersch, Elke Genersch   +5 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Statically Checking Web API Requests in JavaScript

, 2017
Many JavaScript applications perform HTTP requests to web APIs, relying on the request URL, HTTP method, and request data to be constructed correctly by string operations.
Dolby, Julian, Laredo, Jim A., Wittern, Erik, Ying, Annie T. T., Zheng, Yunhui   +4 more
core   +1 more source