Results 1 to 10 of about 30 (29)

Safety of sulfamethoxazole–trimethoprim for the treatment of bacterial infection in outpatient settings: A systematic review and meta‐analysis with active comparator disproportionality analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Sulfamethoxazole–trimethoprim (SMX‐TMP) is a widely used antibiotic for treating bacterial infections, but its safety in adult outpatients remains understudied. This systematic review and meta‐analysis evaluated the safety profile of SMX‐TMP and identified critical research gaps.
Rebecca Preyra, Lujain Ez Eddin, Fatemeh Ahmadi, Atefeh Jafari, Flory T. Muanda   +4 more
wiley   +2 more sources

Implementing Pre‐Emptive Pharmacogenetics: Impact of Early Pharmacogenetic Screening in a Pediatric Oncology Cohort of 1,151 Subjects

Clinical Pharmacology &Therapeutics, EarlyView.
In pediatric oncology, pharmacogenetic guidelines are underutilized and the potential impact of pre‐emptive pharmacogenetic screening remains largely unexplored despite this field's need for individualized approaches. While comprehensive pharmacogenetic guidelines are not yet available for all anticancer drugs, evidence‐based recommendations exist for ...
Emma C. Bernsen, Eugène T.P. Verwiel, Maaike van der Lee, Jesse J. Swen, Marcel Santoso, Leiah J. Brigitha, Rick Admiraal, Bastiaan B.J. Tops, Alwin D.R. Huitema, Patrick Kemmeren, Jayne Y. Hehir‐Kwa, Lidwien M. Hanff, Meta H.M. Diekstra   +12 more
wiley   +1 more source

A Case of Hemophagocytic Lymphohistiocytosis During Immune Checkpoint Inhibitor Treatment for Metastatic Renal Cell Carcinoma, Complicated by Pancytopenia Attributed to Cytomegalovirus Infection

IJU Case Reports, EarlyView.
ABSTRACT Introduction Hemophagocytic lymphohistiocytosis (HLH) is characterized by macrophage and cytotoxic lymphocyte hyperactivation, fever, pancytopenia, liver dysfunction, and abnormal coagulation. However, no specific treatments have been established for HLH caused by immune checkpoint inhibitors.
Tomoko Honda, Hirohito Naito, Yu Osaki, Yoichiro Tohi, Yuki Matsuoka, Takuma Kato, Homare Okazoe, Rikiya Taoka, Nobufumi Ueda, Mikio Sugimoto   +9 more
wiley   +1 more source

Food Safety Practices and Foodborne Illness in Italian Pediatric Oncology and Hematology Centers: A Survey on Behalf of the Infectious Disease Working Group of AIEOP

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Food safety practices are widely recommended for pediatric patients with cancer or undergoing hematopoietic stem cell transplantation (HCT) to mitigate foodborne infectious risks. However, specific measures, such as the neutropenic diet (ND) or low‐microbial diet, lack robust evidence and are inconsistently implemented across ...
Davide Leardini, Gianluca Bossù, Francesco Venturelli, Francesco Baccelli, Edoardo Muratore, Antonio Grasso, Pietro Gasperini, Chiara Pilotto, Letizia Pomponia Brescia, Nagua Giurici, Angelica Barone, Mariacristina Menconi, Elena Soncini, Daniela Onofrillo, Manuela Spadea, Francesco Fabozzi, Pietro Casartelli, Simona Rinieri, Maria Grazia Petris, Valeria Petroni, Paola Muggeo, Katia Perruccio, Cristina Meazza, Francesca Compagno, Francesco Paolo Tambaro, Maura Faraci, Angela Mastronuzzi, Riccardo Masetti, Simone Cesaro   +28 more
wiley   +1 more source

Regional outbreak of parvovirus B19 acute myocarditis in preschool children

Pediatric Investigation, EarlyView.
We recently came across an outbreak of parvovirus B19 related acute myocarditis in preschool children in a specific region in northern Greece. The children exhibited serious morbidity and mortality. All children had very poor left ventricular ejection fraction and required inotropic intensive care unit support.
Filippos‐Paschalis Rorris, Maria Kontou, Meletios Kanakis, Dimitrios Bobos   +3 more
wiley   +1 more source

Hetrombopag: A promising thrombopoietin receptor agonist for the treatment of primary and secondary immune thrombocytopenia

Rheumatology &Autoimmunity, EarlyView.
This review seeks to provide a thorough synthesis of the existing literature on the role of thrombopoietin receptor agonists in the treatment of primary and secondary immune thrombocytopenia, with particular emphasis on the compound Hetrombopag. Abstract Immune thrombocytopenia (ITP) is a rare autoimmune disorder characterized by a platelet count below
Jiaqi Hu, Zhida Fu, Xia Xu, Zhengyi Jin, Xinyu Qian, Weiyu Tao, Taiyan Ma, Dongbao Zhao, Jie Gao   +8 more
wiley   +1 more source

hTERT Increases TRF2 to Induce Telomere Compaction and Extend Cell Replicative Lifespan

Aging Cell, EarlyView.
In contrast to the dogma that a subset of short telomeres initiates senescence, hTERT variants unable to maintain telomere length block senescence by stabilizing TRF2 via inhibiting upstream E3 ubiquitin ligases. This noncanonical hTERT function also compacts telomeres and blocks senescence‐associated DNA damage signaling. Cancer cells expressing hTERT
Nancy Adam, Yang Yang, Mahbod Djamshidi, Sara Seifan, Nicholas S. Y. Ting, Joel Glover, Nicolas Touret, Paul M. K. Gordon, K. V. Vineetha Warriyar, Hokan Krowicki, Christine Kim Garcia, Sharon A. Savage, Aaron A. Goodarzi, Duncan M. Baird, Tara L. Beattie, Karl Riabowol   +15 more
wiley   +1 more source

How low can we go? Comparison of liberal and restrictive red cell transfusion thresholds in paediatric allogeneic haematopoietic stem cell transplantation: A randomized multicentre feasibility trial

British Journal of Haematology, EarlyView.
Optimal red blood cell transfusion thresholds for children with bone marrow failure are uncertain. Children may be able to safely tolerate lower haemoglobin thresholds, thereby reducing transfusions, which have risks. This study in paediatric allogeneic haematopoietic stem cell transplant aimed to assess feasibility of recruitment and protocol ...
H. V. New, E. Sanderson, V. Hopkins, H. Thomas, A. Gassas, M. Adams, B. Gibson, K. Patrick, R. Wynn, L. Hoole, H. Smethurst, M. Lobo‐Clarke, L. Smith, A. Mora, S. J. Stanworth   +14 more
wiley   +1 more source

Comparison of severe aplastic anaemia and lower risk hypoplastic myelodysplastic neoplasms: Critical role of megakaryocyte count in distinguishing aplastic anaemia from myelodysplastic neoplasms

British Journal of Haematology, EarlyView.
In our central morphological review system, megakaryocyte counts are prioritized alongside BM cellularity to differentiate between AA and MDS. A retrospective analysis of patients with SAA and those with LR‐hMDS, registered in that system, revealed a significant difference in outcomes.
Tomoya Maeda, Akira Matsuda, Junya Kanda, Hiroshi Kawabata, Takayuki Ishikawa, Kaoru Tohyama, Akira Kitanaka, Kayano Araseki, Kei Shimbo, Tomoko Hata, Takahiro Suzuki, Hidekazu Kayano, Kensuke Usuki, Maki Shindo‐Ueda, Nobuyoshi Arima, Masaharu Nohgawa, Akiko Ohta, Shigeru Chiba, Yasushi Miyazaki, Shinji Nakao, Keiya Ozawa, Shunya Arai, Mineo Kurokawa, Akifumi Takaori‐Kondo, Kinuko Mitani, the Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes   +25 more
wiley   +1 more source

Real‐world clinical experience with NGS‐based chimerism analyses in haematopoietic stem cell transplant patients

British Journal of Haematology, EarlyView.
This study demonstrates the clinical utility of a next‐generation sequencing (NGS)‐based chimerism assay (CASAL) in haematopoietic stem cell transplantation (HSCT). Compared to conventional short tandem repeat (STR) methods, CASAL showed significantly higher marker informativeness, detecting mixed chimerism (MC) below 5% recipient DNA with a median of ...
Jin Ju Kim, Soon Sung Kwon, Yu Jeong Choi, Yehyun Kang, Yu Jin Park, Saeam Shin, Seung‐Tae Lee, Jong Rak Choi   +7 more
wiley   +1 more source