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New England Journal of Medicine, 2018 Aplastic anemia - bone marrow failure (AA) is defined as pancytopenia with hypocellular bone marrow without signs of marrow fibrosis or of presence of abnormal cells. Recent studies showed that most of AA cases might be mediated by immune mechanisms.
Thomas Menter, Alexandar Tzankov
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Pathogenesis of aplastic anemia [PDF]
Hematology, 2019 Aplastic anemia (AA) is a rare and life-threatening bone marrow failure (BMF) that results in peripheral blood cytopenia and reduced bone marrow hematopoietic cell proliferation. The symptoms are similar to myelofibrosis, myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) making diagnosis of AA complicated.
Hong Liu, Li Wang
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Clinical utility of hematological parameters in aplastic anemia [PDF]
Scientific ReportsHematological parameters available on automated hematology analyzers have been shown to be useful indicators for hematological disorders. However, extensive studies especially in aplastic anemia for these indices are sparse.
Lizhong Zhang +4 more
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Haematologica, 2019 Aplastic anemia is a rare but potentially life-threatening disease that may affect older patients. Data regarding the treatment of aplastic anemia in this ageing population remains scarce.
Adrien Contejean +22 more
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Haematologica, 2018 Oligoclonal expansion of CD8+ CD28− lymphocytes has been considered indirect evidence for a pathogenic immune response in acquired aplastic anemia. A subset of CD8+ CD28− cells with CD57 expression, termed effector memory cells, is expanded in several ...
Valentina Giudice +8 more
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Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment
Blood Advances, 2018 : Treatment of severe aplastic anemia has improved significantly over the past 4 decades. This review will summarize the key areas of progress in the use of allogeneic hematopoietic cell transplantation and nontransplant immunosuppressive therapy (IST ...
George E. Georges +2 more
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Incidence of aplastic anemia in Bangkok. The Aplastic Anemia Study Group [PDF]
Blood, 1991 The annual incidence of aplastic anemia in metropolitan Bangkok, Thailand, and its five suburban provinces was prospectively determined. All patients first diagnosed during the period from January through December 1989 who met specific clinical and pathologic criteria were included. Thirty-two cases were identified, yielding an overall incidence of 3.7
Surapol Issaragrisil +9 more
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Approach to the diagnosis of aplastic anemia.
Blood Advances, 2021 Establishing a diagnosis of aplastic anemia (AA) can be challenging, but it is absolutely critical to appropriate management, especially differentiating between acquired and inherited forms of the disease. The hematology field requires updated diagnostic
A. DeZern, J. Churpek
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Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia
Leukemia, 2021 The prevalence and functional impact of somatic mutations in nonleukemic T cells is not well characterized, although clonal T-cell expansions are common.
S. Lundgren +18 more
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Current Opinion in Internal Medicine, 2008 Most acquired aplastic anemia is the result of immune-mediated destruction of hematopoietic stem cells causing pancytopenia and an empty bone marrow, which can be successfully treated with either immunosuppressive therapy or hematopoietic stem-cell transplantation.In aplastic anemia, oligoclonally expanded cytotoxic T cells induce apoptosis of ...
Neal S, Young +2 more
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