Results 201 to 210 of about 114,772,772 (250)

Controlling Linear and Non‐Linear Mechanics in Multicomponent Hydrogels Through Programmable Supramolecular and Covalent Interactions

Journal of Polymer Science, EarlyView.
Fully synthetic, multi‐component hydrogels are engineered that possess tunable (non)‐linear mechanics by programmable supramolecular and covalent interactions. By changing the type of inter‐network interaction, the linear and non‐linear mechanics of the macroscopic hydrogel were programmed.
Martin G. T. A. Rutten, Laura Rijns, Jingyi Huang, Ruth Cardinaels, Paul H. J. Kouwer, Patricia Y. W. Dankers   +5 more
wiley   +1 more source

Parameterization of the PA Endonuclease Bimetallic Center Reveals the Dynamics of Clinically Relevant Mutations. [PDF]

J Chem Theory Comput
Wang L, Li P, Sztain T.
europepmc   +1 more source

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source

Quality Over Quantity: Targeting Lipoprotein(a) Beyond Circulating Levels. [PDF]

JACC Basic Transl Sci
Tirandi A, Liberale L, Camici GG.
europepmc   +1 more source

Structural and Biochemical Characterization of the Diaminopimelate Epimerase DapF From Pseudomonas aeruginosa PA14

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The emergence of antibiotic resistance in bacteria is a major threat to global public health. To combat increasingly drug‐resistant bacteria like Pseudomonas aeruginosa, new targets for pharmaceuticals need to be explored. One such potential target for P.
Philipp Schneider, Claudia Hanko, Konrad Büssow, Stefan Schmelz, Wulf Blankenfeldt   +4 more
wiley   +1 more source

Cryo-EM structures of apo, agonist- and antagonist-bound heteromeric kainate receptors. [PDF]

Sci Adv
Zhou C, Segura-Covarrubias G, M'Kay Hoffman A, Tajima N.   +3 more
europepmc   +1 more source

Distinct Conformational Switches Control WPD‐Loop Dynamics Across Protein Tyrosine Phosphatase Subfamilies

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Protein Tyrosine Phosphatases (PTPs) regulate cellular signaling by balancing phosphotyrosine levels through a conserved WPD‐loop that switches between open (inactive) and closed (active) conformations. While this conformational change is crucial for catalysis, the structural factors governing this motion remain poorly understood.
Colin L. Welsh, Lalima K. Madan
wiley   +1 more source

Conformational ensembles of the disordered 4E-BP2:eIF4E complex restrained by smFRET experiments. [PDF]

Protein Sci
Smyth S, Liu ZH, Tsangaris TE, Head-Gordon T, Forman-Kay JD, Gradinaru CC.   +5 more
europepmc   +1 more source