Results 191 to 200 of about 114,772,772 (250)

Integrative Network Pharmacology and Transcriptomics Reveal the Mechanism of XuanShi Choudong Recipe in the Treatment of Tic Disorder. [PDF]

Brain Behav
Jue H, Jingying M, Yaqin C, Yulu P, Yanhong C, Jiaye X, Danfei C, Jian C, Xiao-Bo X.   +8 more
europepmc   +1 more source

Rotational Anisotropy Raman Spectrometer for High‐Sensitivity Crystallographic Symmetry Analysis

Laser &Photonics Reviews, EarlyView.
We introduce rotational‐anisotropy Raman spectroscopy, an enhanced scheme that overcomes the limitations of traditional polarization‐resolved Raman techniques. This method reveals previously inaccessible phonon symmetries and resolves directional anisotropy of phonon‐polaritons in benchmark crystals, establishing a powerful new tool for characterizing ...
Di Cheng, Junxiang Li, Shizhuo Luo, Zehao Chen, Xinwei Li   +4 more
wiley   +1 more source

Cross-docking and redocking reveal distinct determinants of success in physics-based and AI-driven binding pose prediction in protein-ligand complexes. [PDF]

RSC Adv
Suri K, Yadav A, Tripathi A, Murugan NA.
europepmc   +1 more source

Ion Activation Methods for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source

Single-sequence based gFET-aptasensors for the discrimination of apo- and holo-RBP4 in human serum. [PDF]

Sci Rep
Xing H, Li R, Zhang Y, Rajpal S, Bolotnikov G, Gruber D, Ruzicka HM, Andersson J, Bozdogan A, Herdina AN, Strassl R, Hasler R, Kleber C, Knoll W, Mizaikoff B, Kissmann AK, Rosenau F.   +16 more
europepmc   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Mechanistic insights into HipA‐mediated bacterial persistence: Role of initial cellular states and toxin expression kinetics

mLife, EarlyView.
Abstract Persistent bacteria subpopulations showing multidrug tolerance pose significant challenges to antibiotic therapy. While the HipBA toxin–antitoxin (TA) system is known to play a role in persister formation, existing studies predominantly focus on its kinase activity and intracellular regulatory pathways, with limited attention to the ...
Jing Zhao, Yixiao Xiong, Hongxia Zhao, Jin Wang, Xiaona Fang   +4 more
wiley   +1 more source

Unlocking the Dynamics of Human SPPL2a: First Atomistic Characterization of an Alzheimer's-Linked Intramembrane Protease. [PDF]

J Chem Inf Model
Dutta S, Singh MK, Dehury B.
europepmc   +1 more source

Robust Position Control of an Electro‐Hydraulic Actuator via Metaheuristic Optimization of a Fractional‐Order PID Controller

International Journal of Mechanical System Dynamics, EarlyView.
ABSTRACT In this study, a robust position control strategy is presented for a two‐stage electro‐hydraulic actuator system using a fractional‐order proportional–integral–derivative (FOPID) controller tuned by Kirchhoff's law algorithm (KLA). Electro‐hydraulic systems exhibit strong nonlinearities, parameter uncertainties, and external disturbances ...
Ridvan Firat Cinar, Davut Izci, Serdar Ekinci, Mohammad Salman, Mohammad Al‐Rabayah, Ali Akdagli, Ali Yildiz, Filiz Karaomerlioglu, Gökhan Yüksek   +8 more
wiley   +1 more source

Aortic disease-linked mutations reveal unexpected convergent allosteric mechanisms of protein kinase G misregulation. [PDF]

Sci Adv
Martinez Pomier K, Jahn L, VanSchouwen B, Mohamed H, Akimoto M, Jung SW, Bertinetti D, Mehringer J, Della Libera L, Cuello F, Herberg FW, Melacini G.   +11 more
europepmc   +1 more source