Results 141 to 150 of about 93,358 (167)

The ASH HematOmics Program supports integrative analysis of genomic and clinical data in hematologic diseases.

Blood
Lu C, Matt GY, Paul R, Wang J, Sioson E, Gangwani K, Acić A, Willems A, Zaldívar Peraza A, Reilly C, Pölönen P, Gao Q, Li Q, Pounds SB, Zeng AGX, Li S, Nadarajah N, Brady SW, Iacobucci I, Haferlach T, Rose MC, Mullighan CG, Zhou X.   +22 more
europepmc   +1 more source

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers [PDF]

Nature Genetics, 2013
Recent studies indicate that a subclass of APOBEC cytidine deaminases, which convert cytosine to uracil during RNA editing and retrovirus or retrotransposon restriction, may induce mutation clusters in human tumors.
Gad Getz, Michael Lawrence, Steven A Roberts   +2 more
exaly   +5 more sources

Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer

Cancer Cell, 2023
Tumor mutational burden and heterogeneity has been suggested to fuel resistance to many targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the mutational signatures of more than 70% of human cancers. However, the mechanism
Yaru Xu, Ping Mu
exaly   +2 more sources

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APOBEC-Induced Mutagenesis in Cancer

Annual Review of Genetics, 2022
The initiation, progression, and relapse of cancers often result from mutations occurring within somatic cells. Consequently, processes that elevate mutation rates accelerate carcinogenesis and hinder the development of long-lasting therapeutics. Recent sequencing of human cancer genomes has identified patterns of mutations, termed mutation signatures,
Christopher D Collins, Steven A Roberts, Tony M Mertz   +2 more
exaly   +3 more sources

APOBEC mediated mutagenesis drives genomic heterogeneity in endometriosis

Journal of Human Genetics, 2022
Endometriosis is a benign gynecologic condition, acting as a precursor of certain histological subtypes of ovarian cancers. The epithelial cells of endometriotic tissues and normal uterine endometrium accumulated somatic mutations in cancer-associated genes such as phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and ...
Sundaramoorthy Revathidevi, Hirofumi Nakaoka, Kazuaki Suda, Naoko Fujito, Arasambattu Kannan Munirajan, Kosuke Yoshihara, Takayuki Enomoto, Ituro Inoue   +7 more
openaire   +2 more sources

Genetic modifiers of APOBEC-induced mutagenesis

2023
Abstract The cytidine deaminases APOBEC3A and APOBEC3B (A3B) are prominent mutators of human cancer genomes. However, tumor-specific genetic modulators of APOBEC-induced mutagenesis are poorly defined. Here, we utilized a screen to identify 61 gene deletions that increase A3B-induced mutations in yeast.
Tony M, Mertz, Elizabeth, Rice-Reynolds, Ly, Nguyen, Anna, Wood, Nicholas, Bray, Debra, Mitchell, Kirill, Lobachev, Steven A, Roberts   +7 more
openaire   +2 more sources

Analysis of gene expression and mutation data points on contribution of transcription to the mutagenesis by APOBEC enzymes. [PDF]

NAR Cancer, 2021
Abstract Since the discovery of the role of the APOBEC enzymes in human cancers, the mechanisms of this type of mutagenesis remain little understood. Theoretically, targeting of single-stranded DNA by the APOBEC enzymes could occur during cellular processes leading to the unwinding of DNA double-stranded structure.
Marat D. Kazanov, Gennady V Ponomarev, Mikhail Gelfand   +2 more
exaly   +4 more sources

The role of APOBEC mutagenesis in the progression and therapeutic guidance of pancreatic cancer

Genomics
APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family-mediated mutagenesis is widespread in human cancers. However, we still have a limited understanding of the biological features and clinical relevance of APOBEC mutagenesis in cancer, particularly in pancreatic cancer.In this study, we conducted a comprehensive analysis of ...
Xiaozhou Yu, Ziyun Liu
exaly   +3 more sources