Results 151 to 160 of about 93,358 (167)

APOBEC Mutagenesis Activity Confers Drug Resistance in Lung Cancer

Cancer Discovery, 2023
Abstract Tyrosine kinase inhibitors induce APOBEC3A, which promotes the emergence of drug-tolerant persister clones.
openaire   +1 more source

Abstract GMM-052: EVIDENCE FOR APOBEC MUTAGENESIS IN CLEAR CELL OVARIAN CARCINOMA

Clinical Cancer Research, 2019
Abstract Clear cell ovarian carcinoma (CCOC) accounts for 1-12% of ovarian epithelial cancers and, notwithstanding early diagnosis, often has poor clinical outcomes. CCOC genomic sequences show strong cytosine to thymine (C-to-T) transition mutation biases (Wang et al., 2017, Nature Genetics; Maru et al., 2017, Gynecologic Oncology ...
Artur S. Serebrenik, Matthew C. Jarvis, Prokopios P. Argyris, William B. Brown, Reuben S. Harris   +4 more
openaire   +1 more source

Abstract 532: Impact of APOBEC mutagenesis on the immune microenvironment of lung adenocarcinoma (LUAC)

Cancer Research, 2016
Abstract Introduction: It is currently unknown how specific mutational processes that sculpt the genome of non-small-cell lung cancer (NSCLC) impact the tumor immune micro-environment. APOBEC-mediated cytidine deamination has emerged as a major source of somatic mutation across several epithelial malignancies, including NSCLC.
Edwin R. Parra, Pan Tong, Humam Kadara, Vassiliki Papadimitrakopoulou, Julie Izzo, Jaime Rodriguez-Canales, Carmen Behrens, John D. Minna, Jing Wang, Ignacio I. Wistuba, John V. Heymach, Ferdinandos Skoulidis   +11 more
openaire   +1 more source

Hypomorphic mutation in the large subunit of replication protein A affects mutagenesis by human APOBEC cytidine deaminases in yeast

G3: Genes, Genomes, Genetics
Abstract Human APOBEC single-strand (ss) specific DNA and RNA cytidine deaminases change cytosines to uracils (U’s) and function in antiviral innate immunity and RNA editing and can cause hypermutation in chromosomes. The resulting U’s can be directly replicated, resulting in C to T mutations, or U–DNA glycosylase can convert the U’s ...
Zachary Kockler, Adam Burkholder, Steven A Roberts   +2 more
exaly   +4 more sources

Abstract 3577: Pan-cancer analysis of mutagenesis by APOBEC cytidine deaminases

Cancer Research, 2016
Abstract The elucidation of mutagenic processes that shape cancer genomes is a fundamental problem whose solution promises insights into new treatment, diagnostic, and prevention strategies. We and others previously identified mutation clusters and genome-wide mutagenesis bearing the single-strand DNA (ssDNA)-specific APOBEC cytidine ...
openaire   +1 more source

2313P APOBEC mutagenesis and macrophage infiltration in cancer

Annals of Oncology, 2023
A. Gazzo, A. Marra, Y. Zhu, A. Gupta, P. Selenica, X. Pei, B. Weigelt, F. Pareja, N. Riaz, J.S. Reis-Filho, S. Chandarlapaty   +10 more
openaire   +1 more source

Rapid/warm autopsy to reveal APOBEC-mutagenesis as driver of heterogeneity of metastatic thoracic tumors.

Journal of Clinical Oncology, 2017
9023 Background: Intratumor heterogeneity has been characterized among multiple cancer types. In lung adenocarcinoma, APOBEC-mutagenesis has been shown to be a source of heterogeneity. However, these data are largely limited to early stage primary tumors.
Nitin Roper, Tapan K Maity, Shaojian Gao, Abhilash Karavattu Venugopalan, Xu Zhang, Romi Biswas, Susan Perry, Constance Cultraro, Chul Kim, Raffit Hassan, Anish Thomas, Arun Rajan, David E Kleiner, Stephen M. Hewitt, Javed Khan, Udayan Guha   +15 more
openaire   +1 more source

Abstract LB476: Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis

Cancer Research
Abstract Mutations in somatic cells are inflicted by both extrinsic and intrinsic sources and contribute over time to cancer. Tobacco smoke contains chemical carcinogens that have been causatively implicated with cancers of the lung and head & neck.
openaire   +1 more source

New insights into APOBEC-mediated mutagenesis in prostate cancer

Nature Reviews Urology, 2023
openaire   +2 more sources

Abstract 151: Spatial patterns of APOBEC mutagenesis in the tumor microenvironment of Asian breast cancer

Cancer Research
Abstract A common germline polymorphism in chromosome 22 involves the deletion of a large portion of the APOBEC3B gene that results in an APOBEC3A-B hybrid transcript. The hybrid transcript increases APOBEC3A activity and therefore increases APOBEC-associated mutagenesis, which is a common and important mutational signature in cancers ...
Zi Ching Tan, Yang Wu, Zhen Wei Neo, Mai Chan Lau, Siow Wee Chang, Joe Poh Sheng Yeong, Soo-Hwang Teo, Jia Wern Pan   +7 more
openaire   +1 more source