Results 21 to 30 of about 132,750 (308)

Molecular recognition of the interaction between ApoE and the TREM2 protein

Translational Neuroscience, 2022
Alzheimer’s disease (AD) is the most common type of dementia. The ε4 allele of the apolipoprotein E (ApoE) gene is the strongest known genetic risk factor for late-onset AD.
Mai Zhenhua, Wei Wenyan, Yu Haibin, Chen Yongze, Wang Yongxiang, Ding Yuanlin   +5 more
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Regional Differences in Effects of APOE epsilon 4 on Cognitive Impairment in Non-Demented Subjects [PDF]

, 2011
Item does not contain fulltextBACKGROUND: The APOE epsilon4 allele is a risk factor for Alzheimer's disease (AD). APOE epsilon4 is common in non-demented subjects with cognitive impairment.
Tsolaki, M, M. Tsolaki, L. Spiru, Spiru, L., Scheltens, P., Verhey, F. R. J., Ewers, M, B. Vellas, R.W. Jones, Elias-Sonnenschein, LS, L. Frölich, Wilcock, G, Kehoe, P. G., Almkvist, O, Kehoe, P.G., Froelich, Lutz, Nobili, F, Olde Rikkert, M., Hampel, H, Verhey, F.R.J., M. Olde Rikkert, P.G. Kehoe, L. Minthon, Frisoni, GB, Elias-Sonnenschein, L.S., Lund University., Frisoni, G. B., P. Scheltens, Wahlund, L. -O., Jones, RW, Frölich, L, Spiru, L, M. Ewers, Wilcock, G., F.R.J. Verhey, Norberg, J., Froelich, L., Schelthens, P, J. Norberg, Vellas, B, Almkvist, Ove, Riqaud, AS, Almkvist, Ove,, G. Wilcock, Frolich, L., Hampel, H., L.-O. Wahlund, Lenoir, H., Norberg, Joakim,, H. Hampel, Minthon, Lennart,, L.S. Elias-Sonnenschein, Jones, R.W., O. Almkvist, F. Nobili, Soininen, H., Graff, C., Norberg, J, Rikkert, M. Olde, Olde Rikkert, M, G.B. Frisoni, NOBILI, FLAVIO MARIANO, Kehoe, PG, Vellas, B., Minthon, Lennart, Frisoni, Giovanni B., Ewers, M., Jones, R. W., Minthon, L, Frisoni, G.B., Minthon, L., Jones, Roy W., Rigaud, A. -S, Wahlund, L.O., Rigaud, A.S., Graff, Caroline, Rigaud, A. S., Visser, P.J., Lenoir, H, Visser, PJ, Wahlund, Lars-Olof, Rigaud, AS, P.J. Visser, H. Lenoir, Almkvist, O., Nobili, F., Graff, C, Frölich, Lutz, Visser, P. J., Tsolaki, M., Elias-Sonnenschein, L. S., Wahlund, L. -O, C. Graff, Wahlund, L. O., Wahlund, LO, Verhey, FR, Scheltens, P, A.-S. Rigaud, Rikkert, Marcel Olde, Soininen, H, Rigaud, A. -S., Elias Sonnenschein, L. S., H. Soininen, Rikkert, M.O., Graff, C,, Froelich, L, Almkvist, O,   +106 more
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Affective symptoms across the life course and resilience in cognitive function

Annals of Human Biology, 2020
Background: Little is known about what factors can modify the relationship between affective symptoms and cognitive function across the life course.
Georgia Bell, Amber John, Darya Gaysina
doaj   +1 more source

تأثیر هشت هفته تمرین هوازی بر برخی عوامل درگیر در متابولیسم کلسترول در هیپوکمپ و نقش آن در بهبود عملکرد شناختی رت‌های نر ویستار [PDF]

فیزیولوژی ورزشی, 2020
در مطالعات به‌طور گسترده به متابولیسم لیپیدهای گردش خون توجه شده است، اما در سال‌های اخیر به متابولیسم لیپید در مغز به‌دلیل ارتباط با برخی اختلال‌های عصبی توجه بیشتری شده است.
زهرا سرلک, مهتاب معظمی, سیدرضا عطارزاده حسینی, رضا قراخانلو   +3 more
doaj   +1 more source

A PANEL OF GENETIC MARKERS FOR ANALYZING THE RISK OF LONG-TERM ADVERSE PROGNOSIS OF CARDIOVASCULAR DISEASES

Атеросклероз, 2018
Aim: to form a panel of genetic markers for analyzing the risk of long-term adverse prognosis of cardiovascular diseases in Russia population. Material and methods.
E. V. Shakhtshneider, P. S. Orlov, L. V. Shcherbakova, D. E. Ivanoshchuk, S. K. Malyutina, V. N. Maksimov, V. V. Gafarov, M. I. Voevoda   +7 more
doaj   +1 more source

APOE polymorphism and its effect on plasma C-reactive protein levels in a large general population sample [PDF]

, 2010
The literature on association between apolipoprotein E (APOE) gene variations and plasma levels of C-reactive protein (CRP) remains inconsistent, mainly due to low statistical power of previous studies.
Pikhart, H., Peasey, Anne, Pikhart, Hynek, Stavek, Petr, Hubacek, J.A., Kubinova, R., Marmot, Michael, Kubinova, Ruzena, Peasey, A., Hubacek, Jaroslav A., Marmot, M., Stavek, P., Bobak, Martin, Bobak, M.   +13 more
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RNA-Seq Mouse Brain Regions Expression Data Analysis: Focus on ApoE Functional Network

Journal of Integrative Bioinformatics, 2017
ApoE expression status was proved to be a highly specific marker of energy metabolism rate in the brain. Along with its neighbor, Translocase of Outer Mitochondrial Membrane 40 kDa (TOMM40) which is involved in mitochondrial metabolism, the corresponding
Babenko Vladimir N., Smagin Dmitry A., Kudryavtseva Natalia N.   +2 more
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Microbiota and Alzheimer's disease: Toward new clinical approaches [PDF]

Medicinski Podmladak
Alzheimer’s disease (AD) is now viewed as a systemic disorder in which genetics, the gut microbiome and immune dysregulation converge to accelerate amyloid-β (Aβ) and tau pathology. Genetic studies have identified 70 risk loci. The strongest AD risk loci
Đokić Jelena, Dinić Miroslav
doaj   +1 more source

Effect of Apolipoprotein E epsilon 4 on the association between health behaviors and cognitive function in late midlife [PDF]

, 2010
The extent to which the effect of risk factors on cognitive ageing is dependent on APOE epsilon 4 remains unclear. The objective of this study is to examine whether APOE epsilon 4 allele modifies the association between health behaviors and cognition in ...
Kumari, Meena, Singh-Manoux, Archana, Kivimaki Mika, Séverine Sabia, Sabia, Séverine, Mika Kivimaki, Kivimaki, Mika, Sabia Séverine, Kivimaki, M, Singh-Manoux Archana, Archana Singh-Manoux, Kumari Meena, Martin J Shipley, Meena Kumari, Singh-Manoux, A, Shipley, MJ, Shipley Martin J, Sabia, S, Kumari, M, Shipley, Martin   +19 more
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APOE genotype and entorhinal cortex volume in non-demented community-dwelling adults in midlife and early old age [PDF]

, 2012
Copyright © 2012 IOS PressThis article has been made available through the Brunel Open Access Publishing Fund.The apolipoprotein E (APOE) ε4 allele is a risk factor for the neuropathological decline accompanying Alzheimer's disease (AD) while, conversely,
Bunce, David, Perminder Sachdev, Cherbuin, N, Anstey, KJ, David Bunce, Kaarin J. Anstey, Bunce, D, Prapti Gautam, Simon Easteal, Gautam, P, Easteal, S, Cherbuin, Nicolas, Anstey, Kaarin, Gautam, Prapti, Sachdev, Perminder Singh, Nicolas Cherbuin, Sachdev, P, Easteal, Simon   +17 more
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