Results 241 to 250 of about 121,312 (312)

Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases

Obesity Reviews, EarlyView.
ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar, Joanna Razafiarison, Fawaz Alzaid, Fahd Al‐Mulla, Rasheed Ahmad   +4 more
wiley   +1 more source

ApoE expression across the CNS: Who, What, Where, When, and How (much)? [PDF]

Mol Neurodegener Adv
Nolt GL, Lucido CC, Smith LM, Johnson LA.   +3 more
europepmc   +1 more source

Far‐infrared irradiation attenuates platelet‐derived growth factor‐stimulated vascular smooth muscle cell migration through protein phosphatase 2A‐mediated Akt inhibition

Photochemistry and Photobiology, EarlyView.
FIR irradiation enhances the physical association between Akt and PP2Ac in VSMCs, independent of the hyperthermal effect of FIR rays. The increased binding between Akt and PP2Ac induced by FIR irradiation facilitates the dephosphorylation of Akt at Ser473.
Na‐Young Lee, Seo‐Hyeon Kim, Young Jin Kang, Il‐Kug Kim, Yun‐Jin Hwang, Du‐Hyong Cho   +5 more
wiley   +1 more source

APOE ε4 and amyloid status moderate the associations between sleep, physical activity, and tau-PET burden in cognitively unimpaired older adults. [PDF]

Alzheimers Dement
Callow DD, Rani N, Smith JC, Soldan A, Pettigrew C, Spira AP, Albert M, Bakker A, BIOCARD Research Team.   +8 more
europepmc   +1 more source

Of mice and men—The emerging oral–gut–brain axis of health and disease

Periodontology 2000, EarlyView.
Abstract Objectives Oral health's inextricable links to systemic health are highlighted by the emerging oral–gut–brain axis and other well‐known axes. There is growing evidence of a complex oral–gut–brain axis linking mouth and gut microbiomes with the central nervous system.
Yvonne L. Hernandez‐Kapila, Daniel J. Weisenberger   +1 more
wiley   +1 more source

Proteomic signatures of the APOE ε4 and APOE ε2 genetic variants and Alzheimer's disease. [PDF]

Nat Aging
Lu L, Pichet Binette A, Hristovska I, Janelidze S, Smets B, Cumplido-Mayoral I, Vasanthakumar A, Milkovich B, Global Neurodegeneration Proteomics Consortium (GNPC), An L, Ossenkoppele R, Krish V, Imam F, Palmqvist S, Vogel JW, Stomrud E, Hansson O, Mattsson-Carlgren N.   +17 more
europepmc   +1 more source

Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI

Experimental Physiology, EarlyView.
Abstract Human cerebrovasculature is finely tuned to enable local changes in blood flow to meet the brain's demands, whilst protecting the brain from systemic changes in blood pressure, both acutely during a heartbeat and chronically over time. This review summarises cerebrovascular structure and function, their role in disease and neurodegeneration ...
Ian D. Driver, Kevin Murphy
wiley   +1 more source

Depressive symptoms as a risk factor or prodrome of dementia: multi-state cognitive transitions modified by age and polygenic risk. [PDF]

J Prev Alzheimers Dis
Ren Z, Zhang R, Guo S, Zhao Y, Liu J, Zheng X.   +5 more
europepmc   +1 more source

TREM2+ macrophages accumulate in childhood IgA nephropathy and soluble TREM2 represents a reliable non‐invasive biomarker

Experimental Physiology, EarlyView.
Abstract IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis of childhood IgAN remains unclear, and there is a lack of effective non‐invasive biomarkers for this disease. Single‐cell RNA sequencing was performed in children with IgAN to delineate cellular and molecular compositions, and subcluster ...
Ling Yu, Xuan Gang, Jingjing Wang, Guoping Huang, Qiuyu Li, Weizhong Gu, Haidong Fu, Jianhua Mao   +7 more
wiley   +1 more source

Longevity and cognitive resilience in a Colombian family carrying the <i>APOE</i> ε2 variant. [PDF]

J Alzheimers Dis
Guerrero A, Galvis-Garrido ND, Bocanegra Y, Vásquez D, Becerra JC, Zuluaga Y, Baena A, Zubiri V, Alzate D, Osorio L, Hincapié L, Madrigal L, García G, Guzmán C, Restrepo F, Vidal M, Martínez L, Martínez JE, Malotaux V, Tristão-Pereira C, Perez-Corredor P, Vacano GN, Lopera F, Arboleda-Velasquez JF, Quiroz YT, Aguillon D.   +25 more
europepmc   +1 more source