Results 201 to 210 of about 96,484 (269)

Retatrutide‐Associated Improvements in Cardiovascular Risk Biomarkers in Adults With Obesity With or Without Type 2 Diabetes

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To further characterise the effects of retatrutide on cardiometabolic risk, lipoprotein and inflammatory biomarkers were assessed post hoc in phase 2 trials of adults with obesity/overweight with or without type 2 diabetes (T2D). Materials and Methods Data were analysed from two randomised, double‐blind, placebo‐controlled phase 2 trials.
Giacomo Ruotolo   +13 more
wiley   +1 more source

Heat shock protein 72 attenuates atherosclerosis in apolipoprotein E‐deficient mice

open access: yesJournal of Diabetes Investigation, EarlyView.
Heat shock (HS) + mild electrical stimulation (MES)‐induced heat shock protein (HSP)72 expression prevents atherogenesis in HSP72+/+/ApoE−/− mice. HS + MES‐induced HSP72 expression reduces macrophage infiltration, oxidative stress, JNK activity, and MCP‐1 expression, and alters macrophage polarity from M1 to M2.
Rintaro Yoshizumi   +12 more
wiley   +1 more source

Liraglutide reprograms vascular smooth muscle cell metabolism to suppress extracellular matrix remodeling in diabetic atherosclerosis

open access: yesJournal of Diabetes Investigation, EarlyView.
Liraglutide reverses hyperglycemia‐induced metabolic reprogramming in vascular smooth muscle cells, restoring mitochondrial function and AMPK/PGC‐1α signaling while suppressing mTOR activation and HIF‐1α accumulation. These changes attenuate extracellular matrix remodeling, reduce atherosclerotic plaque burden, and improve plaque stability in diabetic ...
Kun Zhu   +6 more
wiley   +1 more source

Driving Navigation in Older Adults Across the Alzheimer's Disease Continuum

open access: yesJournal of the American Geriatrics Society, EarlyView.
ABSTRACT Background and Objectives To examine whether time from amyloid positivity (amyloid time), a continuous measure of biological Alzheimer's disease (AD) progression, is associated with differences in navigation‐related driving behaviors among older adults.
Yiqi Zhu   +8 more
wiley   +1 more source

APOE ε4 influences the widespread TDP-43 pathological subtype in sporadic amyotrophic lateral sclerosis. [PDF]

open access: yesActa Neuropathol
Hatano Y   +5 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy