Results 211 to 220 of about 131,925 (308)

New Genetic Associations Between Alzheimer's Disease and Its Key Risk Factors. [PDF]

Psychogeriatrics
Gholami M, Ahmadi AA, Niaki MAA, Asouri M, Saeedi S, Amoli MM, Larijani B.   +6 more
europepmc   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

TMEM106B is a selective modulator of TDP-43 pathology in Alzheimer's disease. [PDF]

Alzheimers Dement
Reeves MM, Calliari A, Todd TW, Maroto Cidfuentes C, Jansen-West K, Yue M, Song Y, Dunmore J, Rawlinson B, Engelberg-Cook E, DeTure M, Day GS, Graff-Radford NR, Boeve BF, Knopman DS, Petersen RC, Cook CN, Murray ME, Dickson DW, Josephs KA, Petrucelli L, Prudencio M.   +21 more
europepmc   +1 more source

'Authenticity' and 'Inauthenticity' in Sneaker Culture

Japanese Review of Cultural Anthropology, 2019
openaire   +1 more source

Protosappanin A Alleviates Atherosclerosis by Regulating the MDM2/GPX4 Axis‐Mediated Endothelial Ferroptosis

Phytotherapy Research, EarlyView.
PTA alleviates atherosclerosis by regulating the MDM2/GPX4 axis‐mediated endothelial ferroptosis. ABSTRACT Endothelial ferroptosis is a crucial pathogenic driver of atherosclerosis (AS) progression. Protosappanin A (PTA), a bioactive compound from Caesalpinia sappan L., protects cardiovascular vessels by regulating ferroptosis.
Jiamei Fu, Lin Zhu, Wenwei Yang, Mengnan Li, Zhixin Wu, Shude Sun, Yabin Zhou   +6 more
wiley   +1 more source

Heparanase gene deficiency suppresses atherosclerosis progression and enhances plaque stability in apolipoprotein E gene knockout mice with diabetes. [PDF]

Clin Sci (Lond)
Nguyen TK, Baxter AA, Bourchier C, Phan TK, Chan E, Poon IKH, Thomas SR, Hulett MD.   +7 more
europepmc   +1 more source

A Ferrous‐Supply‐Regenerating Lipid Nanoparticle Integrating RNAi Induces Ferroptosis for Cancer Therapy

Small, EarlyView.
ABSTRACT Targeting iron‐dependent ferroptosis with siRNA has emerged as a promising strategy for cancer treatment. The concept of ferrous‐supply regeneration, inspired by electro‐Fenton technology, has also gained interest as a non‐apoptotic approach to induce ferroptosis.
Dun Hu, Yun‐Hua Xu, Dan Peng, Qi Tan, Jun‐Lin Jiang, Sheng‐Dan Nie, Shan Wang   +6 more
wiley   +1 more source

Mendelian randomization and drug repurposing analysis identifies APOE as a potential therapeutic target for low back pain. [PDF]

Medicine (Baltimore)
Yang J, Qi W, Wang D, Mei Z, Pan H, He Y.   +5 more
europepmc   +1 more source

Protein Corona Engineering of Lipid Nanoparticles Enables Efficient Functional Gene Silencing in the Liver

Small, EarlyView.
By shaping the protein corona, lipid composition directs LNP tropism and enables the preferential delivery of a TIMP1‐targeting siRNA to liver macrophages. In a murine model of primary biliary cholangitis, this strategy promoted macrophage reprogramming and attenuated liver fibrosis.
Naths G. Sukubo, Serena Renzi, Martina B. Violatto, Leila Altigieri, Anna L. Capriotti, Andrea Cerrato, Aldo Laganà, Luca Digiacomo, Erica Quagliarini, Antonio Minopoli, Massimiliano Papi, Daniela Pozzi, Carlo A. Scirè, Pietro Invernizzi, Paolo Bigini, Giulio Caracciolo   +15 more
wiley   +1 more source

Amyloid-<i>β</i> modulates APOE ε4 effects on cognition but not on targeted structural or functional connectivity measures over 2 years in pre-dementia adults. [PDF]

Front Aging Neurosci
Wei H, Zhang T, Liang Z, Li M, Kong M, Ba M.   +5 more
europepmc   +1 more source