Results 121 to 130 of about 96,484 (269)

<i>APOE</i> Genotype Modifies the Predictive Performance of Plasma Biomarkers for Amyloid Plaque Burden in Subjective Cognitive Decline. [PDF]

J Korean Med Sci
Lee HJ, Yoon B, Hong YJ, Jeong JH, Kim S, Wang MJ, Choi SH, Ryu JS, Kang S, Park KH, Yang DW.   +10 more
europepmc   +1 more source

'Quantum mechanics' and 'scientific explanation' an explanatory strategy aiming at providing 'understanding'

, 2008
Empirical studies persistently indicate that the usual explanatory strategies used in quantum mechanics (QM) instruction fail, in general, to yield understanding. In this study, we propose an instructional intervention, which: (a) incorporates into its subject matter a critical comparison of QM scientific content with the fundamental epistemological ...
openaire   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Apolipoprotein E Gene ϵ4 Allele is Associated with Atherosclerosis in Multiple Vascular Beds

International Journal of General Medicine
Youni Lin, Min Yang, Qifeng Liu, Yufu Cai, Zhouhua Zhang, Chongfei Xu, Ming Luo Center for Cardiovascular Diseases, Meizhou People’s Hospital, Meizhou, People’s Republic of ChinaCorrespondence: Youni Lin, Center for Cardiovascular Diseases, Meizhou ...
Lin Y, Yang M, Liu Q, Cai Y, Zhang Z, Xu C, Luo M   +6 more
doaj  

Cerebrovascular reactivity and plasma p-tau181 in Alzheimer's disease: Insights into APOE-related vascular phenotypes. [PDF]

Alzheimers Dement (N Y)
Di Donna MG, Bagnato MR, Bonomi CG, Motta C, Centonze D, Martorana A, Diomedi M.   +6 more
europepmc   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults. [PDF]

Alzheimers Dement
Abdelmessih GT, Bransby L, Cummins H, Jackson ML, Lim YY.   +4 more
europepmc   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

Haplotype-resolved DNA methylation at the <i>APOE</i> locus identifies allele-specific epigenetic signatures relevant to Alzheimer's disease risk. [PDF]

NPJ Dement
Genner RM, Meredith M, Daida K, Moller A, Weller C, Ayuketah A, Jerez PA, Akeson S, Malik L, Baker B, Kouam C, Paquette K, Catching A, Bromberek S, Hu F, Reed X, Marenco S, Auluck P, Mandal A, Paten B, Gibbs JR, Jain M, Cookson MR, Singleton AB, Nalls M, Blauwendraat C, Billingsley KJ.   +26 more
europepmc   +1 more source

Emerging Human‐Based Research Technologies for Investigating the Pathomechanisms and Therapies for Vascular Diseases

iNew Medicine, EarlyView.
ABSTRACT It is estimated that a large proportion of drug candidates fail in human clinical trials, mainly because animal models cannot fully replicate human disease and because of differential responses to various medications between humans and animals.
Weiping Ding, Iqra Ilyas, Suowen Xu
wiley   +1 more source