Results 161 to 170 of about 131,925 (308)

'Career preference', 'transients' and 'converts': A study of social workers' retention in child protection and welfare

open access: yes, 2011
Both domestically and internationally, retaining social workers in statutory child protection and welfare work has been identified as a problem. However, this issue appears to receive only modest attention from researchers. This paper reports on the findings of a study that examined the retention of ‘front line’ child protection and welfare social ...
openaire   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi   +6 more
wiley   +1 more source

What's in a name? The value of 'Entrepreneurs' compared to 'Self-Employed'...but what about 'Freelancing' or 'IPro'?

open access: yes
This paper is concerned with those individuals who do not fit easily or comfortably into traditional notions of employment. Variously described as 'self-employed', 'sole traders', 'own account workers,' 'freelancers,' 'independent contractors' - or more accurately, as independent professionals (IPros ...
openaire   +1 more source

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu   +9 more
wiley   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

open access: yesExploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi   +5 more
wiley   +1 more source

Hepatic anti-inflammatory effect of hexane extracts of Dioscorea batatas Decne: Possible suppression of toll-like receptor 4-mediated signaling

open access: yes, 2017
The hepatic anti-inflammatory potential of hexane extracts of Dioscorea batatas Decne edible part(EDH-1e) and bark(EDH-2b) were investigated in Western-type diet-fed apolipoprotein E null [ApoE(-/-)] mice and HepG2 cells. EDH-1e and EDH-2b suppressed the 
표석능   +6 more
core  

Synthesis of the WXYZA'B'C'D'E'F' Ring of Maitotoxin

open access: yesJournal of Synthetic Organic Chemistry, Japan, 2023
Umeno, Keitaro, Oishi, Tohru
openaire   +1 more source

ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease

open access: yes
International audienceAlzheimer’s disease (AD), the most common cause of dementia, is characterized by the accumulation of amyloid-β (Aβ) in senile plaques and abnormally hyperphosphorylated tau proteins in neurofibrillary tangles.
Holtzman, David   +7 more
core   +1 more source

Cross-tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer's disease. [PDF]

open access: yesAlzheimers Dement
Shvetcov A   +19 more
europepmc   +1 more source

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