Results 71 to 80 of about 131,925 (308)

Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study. [PDF]

, 2012
The E4 allele of the ApoE gene has consistently been shown to be related to an increased risk of Alzheimer's disease (AD). The E4 allele is also associated with functional and structural grey matter (GM) changes in healthy young, middle-aged and older ...
Miller, Julia, Rujescu, D., Lamberton, Franck, David Prvulovic, O'Dwyer, Laurence, Tanner, C., Dan Rujescu, Harald Hampel, Julia Miller, Prvulovic, D., Matura, Silke, Lamberton, F., Hampel, Harald, Laurence O'Dwyer, Prvulovic, David, Matura, S., Scheibe, M., O'Dwyer, L.G., Colby Tanner, Tanner, Colby, Hampel, H., Franck Lamberton, Scheibe, Monika, Silke Matura, Monika Scheibe, Miller, J., Rujescu, Dan   +26 more
core   +3 more sources

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Mitochondrial genome as a therapeutic target — from evolutionary biology of the honeybee to personalized human medicine: A scoping review

Кубанский научный медицинский вестник
Introduction. The mitochondrial genome represents a unique evolutionary platform, combining a highly conserved gene count with exceptional variability in structure, compactness, and replication mechanisms.Objective.
S. D. Nurbaev
doaj   +1 more source

Genetic Effects of NDUFAF6 rs6982393 and APOE on Alzheimer’s Disease in Chinese Rural Elderly: A Cross-Sectional Population-Based Study

Clinical Interventions in Aging, 2022
Yingzhe Cheng,1 Yuanjing Li,2 Xiaoyan Liang,3,4 Pin Wang,3 Wenxin Fa,1 Cuicui Liu,1,3,4 Yongxiang Wang,1,3,4 Keke Liu,5 Nan Wang,3,4 Yifeng Du1,3,4 1Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University ...
Cheng Y, Li Y, Liang X, Wang P, Fa W, Liu C, Wang Y, Liu K, Wang N, Du Y   +9 more
doaj  

Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping

Alzheimer’s Research & Therapy, 2022
Background Genetic variants within the APOE locus may modulate Alzheimer’s disease (AD) risk independently or in conjunction with APOE*2/3/4 genotypes.
Michael E. Belloy, Sarah J. Eger, Yann Le Guen, Vincent Damotte, Shahzad Ahmad, M. Arfan Ikram, Alfredo Ramirez, Anthoula C. Tsolaki, Giacomina Rossi, Iris E. Jansen, Itziar de Rojas, Kayenat Parveen, Kristel Sleegers, Martin Ingelsson, Mikko Hiltunen, Najaf Amin, Ole Andreassen, Pascual Sánchez-Juan, Patrick Kehoe, Philippe Amouyel, Rebecca Sims, Ruth Frikke-Schmidt, Wiesje M. van der Flier, Jean-Charles Lambert, for the European Alzheimer & Dementia BioBank (EADB), Zihuai He, Summer S. Han, Valerio Napolioni, Michael D. Greicius   +28 more
doaj   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

Macrophage-specific apoE gene repair reduces diet-induced hyperlipidemia and atherosclerosis in hypomorphic Apoe mice. [PDF]

PLoS ONE, 2012
Apolipoprotein (apo) E is best known for its ability to lower plasma cholesterol and protect against atherosclerosis. Although the liver is the major source of plasma apoE, extra-hepatic sources of apoE, including from macrophages, account for up to 10 ...
Nathalie Gaudreault, Nikit Kumar, Victor R Olivas, Delphine Eberlé, Joseph H Rapp, Robert L Raffai   +5 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Effects of toxic apolipoprotein E fragments on Tau phosphorylation and cognitive impairment in neonatal mice under sevoflurane anesthesia

Brain and Behavior, 2022
Background Anesthesia induces Tau phosphorylation and cognitive impairment in young, but not adult, mice. Apolipoprotein E (ApoE) may play a protective role in neuronal activity and injury repair, whereas its toxic fragments are reported to induce ...
Yang Yu, Man Yang, Xiaoli Zhuang, Jiacheng Pan, Yue Zhao, Yonghao Yu   +5 more
doaj   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source