Results 151 to 160 of about 131,925 (308)

Human Fibroblast–Myeloid Cell Tissue Atlas Across the Lungs, Synovium, Skin, and Heart

Arthritis &Rheumatology, EarlyView.
Objective The availability of single‐cell RNA sequencing (scRNAseq) data in different tissues and disease states provides an opportunity to compare cellular subsets and identify common and unique cellular activation. In this study, we aimed to characterize shared and tissue‐specific myeloid and stromal phenotypes and to uncover key cellular subtypes ...
Lucy MacDonald, Katerina Apostolopoulou, Olympia Hardy, Melpomeni Toitou, Gabriela Kania, Przemyslaw Blyszczuk, Raphael Micheroli, Thomas D. Otto, Mariola Kurowska‐Stolarska, Caroline Ospelt   +9 more
wiley   +1 more source

'Effortful', 'needy' and 'freeloader' Constructions of unemployed people's deservingness in Finnish parliamentary discussions

, 2020
Peer ...
openaire   +1 more source

Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect?

, 2017
Fidel Vila-Rodriguez,1 Donna J Lang,2 Heather Baitz,3 Kristina Gicas,3 Allen E Thorton,3 Thomas S Ehmann,1 Geoff N Smith,1 Alasdair M Barr,4 Ivan J Torres,1 Lili C Kopala,1 G William MacEwan,1 Daniel J Müller,5 James L Kennedy,5 William G ...
Kopala LC, MacEwan GW, Lang DJ, Kennedy JL, Baitz H, Müller DJ, Thornton AE, Smith GN, Barr AM, Torres IJ, Ehmann TS, Gicas K, Honer WG, Vila-Rodriguez F   +13 more
core  

APOE as a risk factor for Alzheimer’s disease and lipid metabolism disorders: molecular analysis

The gene encoding apolipoprotein E (APOE) plays a key role in many biological processes, including lipid metabolism, brain homeostasis, and functioning of the circulatory system.
Szafraniec, Kacper, Ewa Kowalska, Jarosław Rachuna, Madej, Łukasz, Kacper Szafraniec, Łukasz Madej, Rachuna, Jarosław, Kowalska, Ewa   +7 more
core   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Carrier‐free self‐assembled nanomedicine for combination‐therapy of acute myeloid leukemia

BMEMat, EarlyView.
CPDS combines drugs with three different mechanisms of action to achieve a multi‐mechanism combination therapy for AML by directly killing tumor cells and activating anti‐tumor immunity. Abstract As the main acute myeloid leukemia (AML) clinical treatment, the chemotherapy alone cannot meet the clinical therapeutic needs due to the high heterogeneity ...
Meihong Chai, Rui Zhang, Haiyin Yang, Jiyue Xing, Tianyuan Hu, Mengxi Zhu, Rui Li, Xiaoli Chen, Beibei Zhao, Yang Lan, Stefan Barth, Yuanyu Huang, Li Zhang, Mengjie Zhang, Huining He   +14 more
wiley   +1 more source

'Collaborative' and 'Democratic' Professionalisms : Alternatives to 'Traditional' and 'Managerialist' Approaches to Teacher Autonomy?

Educational Studies in Japan, 2006
WHITTY, Geoff, WISBY, Emma
openaire   +1 more source

ApoE reguliert das Überleben kortikospinaler Neurone durch ApoER2

, 2013
This study was designed to characterize the role of ApoER2 and its ligand ApoE in the regulation of neuronal survival of normally aging CSN and after axonal injury.
Farsian, Farnas
core  

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Differential course of HIV-1 infection and apolipoprotein E polymorphism

Open Medicine, 2007
Corder Elizabeth, Galeazzi Luciano, Franceschi Claudio, Cossarizza Andrea, Paganelli Roberto, Pinti Marcello, Mussini Cristina, Borghi Vanni, Pinter Elena, Cristofaro Rita, Galeazzi Roberta, Perini Marino, Aiuti Fernando, Giunta Sergio   +13 more
doaj   +1 more source