Human central nervous system (CNS) ApoE isoforms are increased by age, differentially altered by amyloidosis, and relative amounts reversed in the CNS compared with plasma [PDF]
, 2016 The risk of Alzheimer's disease (AD) is highly dependent on apolipoprotein-E (apoE) genotype. The reasons for apoE isoform-selective risk are uncertain; however, both the amounts and structure of human apoE isoforms have been hypothesized to lead to ...
Baker-Nigh, Alaina T +11 more
core +3 more sources
İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi, 2019 Amaç: Ateroskleroz kaynaklı Koroner Arter Hastalığı (KAH), multifaktöriyel ve poligenik kompleks bir hastalıktır. Son yıllarda yapılan çalışmalarda KAH ile ilişkili bazı genetik varyantlar öne çıkmıştır.
Erhan Teker +3 more
doaj +1 more source
Npp1 promotes atherosclerosis in ApoE knockout mice. [PDF]
, 2011 Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) generates inorganic pyrophosphate (PP(i)), a physiologic inhibitor of hydroxyapatite deposition.
Nitschke, Yvonne +3 more
core +1 more source
APOE genetic variants and apoE, miR-107 and miR-650 levels in Alzheimer’s disease
Folia Neuropathologica, 2019 Alzheimer’s disease (AD) is a progressive neurodegenerative dementia in adults. Pathogenesis of AD depends on various factors, including APOE genetic variants, apolipoprotein E (apoE) phenotype and oxidative stress, which may promote both DNA and RNA ...
Michal Prendecki +7 more
doaj +1 more source
C2238/αANP modulates apolipoprotein E through Egr-1/miR199a in vascular smooth muscle cells in vitro [PDF]
, 2015 Subjects carrying the T2238C ANP gene variant have a higher risk to suffer a stroke or myocardial infarction. The mechanisms through which T2238C/αANP exerts detrimental vascular effects need to be fully clarified.
Bianchi, Franca +9 more
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Influence of APOE and RNF219 on Behavioral and Cognitive Features of Female Patients Affected by Mild Cognitive Impairment or Alzheimer's Disease. [PDF]
, 2018 The risk for Alzheimer's disease (AD) is associated with the presence of the ?4 allele of Apolipoprotein E (APOE) gene and, recently, with a novel genetic variant of the RNF219 gene.
Assogna, Francesca +14 more
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White matter differences between healthy young ApoE4 carriers and non-carriers identified with tractography and support vector machines. [PDF]
, 2012 The apolipoprotein E4 (ApoE4) is an established risk factor for Alzheimer's disease (AD). Previous work has shown that this allele is associated with functional (fMRI) changes as well structural grey matter (GM) changes in healthy young, middle-aged and ...
Hampel, Harald +7 more
core +7 more sources
Apolipoprotein E and Atherosclerosis: From Lipoprotein Metabolism to MicroRNA Control of Inflammation. [PDF]
, 2018 Apolipoprotein (apo) E stands out among plasma apolipoproteins through its unprecedented ability to protect against atherosclerosis. Although best recognized for its ability to mediate plasma lipoprotein clearance in the liver and protect against ...
Hasty +6 more
core +2 more sources
Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study. [PDF]
, 2010 INTRODUCTION: Evidence from clinical samples and geographically limited population studies suggests that vascular health, diabetes and apolipoprotein epsilon4 (APOE) are associated with dementia. METHODS: A population-based sample of 856 individuals aged
Fisher, Gwenith G +8 more
core +5 more sources
Alzheimer disease genetic risk factor APOE e4, and cognitive abilities in 111,739 UK Biobank participants [PDF]
, 2016 Background: the apolipoprotein (APOE) e4 locus is a genetic risk factor for dementia. Carriers of the e4 allele may be more vulnerable to conditions that are independent risk factors for cognitive decline, such as cardiometabolic diseases.
Anderson, Jana +14 more
core +1 more source