Results 31 to 40 of about 121,312 (312)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

PHARMACOGENETIC FEATURES OF THERAPY OF PATIENTS WITH ATHEROSCLEROSIS

Архивъ внутренней медицины, 2018
The complexity of therapy of lipid metabolism disorders is not only in comorbidity and polypragmasia, but also in predicting a genetically determined response to the treatment.
A. L. Khokhlov, A. N. Yavorsky, N. O. Pozdnyakov, J. V. Rybachkova, E. S. Emelianov, A. A. Khokhlov, A. E. Miroshnikov, S. O. Pozdnyakov   +7 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

APOE GENE POLYMORPHISM: THE IMPACT OF APOE4 ALLELE ON SYSTEMIC INFLAMMATION AND ITS ROLE IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE

Медицинская иммунология, 2018
ApoE is a member of lipoprotein family. It is the most common lipoprotein in the central nervous system (CNS), secreted by astrocytes, microglia, neurons and immunocompetent cells, including lymphocytes, monocytes and macrophages.
I. K. Malashenkova, S. A. Krynskiy, M. V. Mamoshina, N. A. Didkovskiy   +3 more
doaj   +1 more source

APOE-independent dEQ biomarkers (unrelated to APOE by Path c).

, 2017
APOE-independent dEQ biomarkers (unrelated to APOE by Path c).
Ram Bishnoi (3836311), Donald R. Royall (695528), Safa Al-Rubaye (3836308), Raymond F. Palmer (695527)   +3 more
core   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study. [PDF]

, 2012
The E4 allele of the ApoE gene has consistently been shown to be related to an increased risk of Alzheimer's disease (AD). The E4 allele is also associated with functional and structural grey matter (GM) changes in healthy young, middle-aged and older ...
Miller, Julia, Rujescu, D., Lamberton, Franck, David Prvulovic, O'Dwyer, Laurence, Tanner, C., Dan Rujescu, Harald Hampel, Julia Miller, Prvulovic, D., Matura, Silke, Lamberton, F., Hampel, Harald, Laurence O'Dwyer, Prvulovic, David, Matura, S., Scheibe, M., O'Dwyer, L.G., Colby Tanner, Tanner, Colby, Hampel, H., Franck Lamberton, Scheibe, Monika, Silke Matura, Monika Scheibe, Miller, J., Rujescu, Dan   +26 more
core   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Polymorphisms of Proinflammatory Cytokines in Relation to APOE Epsilon 4 and Risk of Alzheimer’s Disease in the Lithuanian Population

Medicina, 2019
Background and objective: Neuroinflammation is one of the pathological pathways of Alzheimer’s disease (AD), mediating the progression of neurodegeneration.
Greta Pšemeneckienė, Kęstutis Petrikonis, Daiva Rastenytė   +2 more
doaj   +1 more source

Effect of Apolipoprotein E epsilon 4 on the association between health behaviors and cognitive function in late midlife

, 2010
The extent to which the effect of risk factors on cognitive ageing is dependent on APOE epsilon 4 remains unclear. The objective of this study is to examine whether APOE epsilon 4 allele modifies the association between health behaviors and cognition in ...
Kumari, Meena, Singh-Manoux, Archana, Kivimaki Mika, Séverine Sabia, Sabia, Séverine, Mika Kivimaki, Kivimaki, Mika, Sabia Séverine, Kivimaki, M, Singh-Manoux Archana, Archana Singh-Manoux, Kumari Meena, Martin J Shipley, Meena Kumari, Singh-Manoux, A, Shipley, MJ, Shipley Martin J, Sabia, S, Kumari, M, Shipley, Martin   +19 more
core   +1 more source